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Publicações - ciências biológicas

Effects of Benzodiazepines on Acinar and Myoepithelial Cells Tatiana Maria Folador Mattioli; Ana Maria Trindade Grégio; Luciana Reis de Azevedo-Alanis; Silvana Silva Sapeli; Antonio Adilson Soares de Lima; Lúcia de Noronha; Edvaldo Antonio Ribeiro Rosa; Yusuf S Althobaiti; Youssef Sari; Sérgio Aparecido Ignácio Frontiers in Pharmacology, v. 7, p. 1-8, 2016 DOI Palavra-chave: Benzodiazepines; Salivary glands; Acinar cell; Myoepithelial cell Áreas do conhecimento: Ciências da Saúde; Odontologia; Clínica Odontológica; Patologia Oral; Ciências Biológicas; Farmacologia; Farmacologia Geral resumo ... Background: Benzodiazepines (BZDs), the most commonly prescribed psychotropic drugs with anxiolytic action, may cause hyposalivation. It has been previously shown that BZDs can cause hypertrophy and decrease the acini cell number. In this study, we investigated the effects of BZDs and pilocarpine on rat parotid glands, specifically on acinar, ductal, and myoepithelial cells.Methods: Ninety male Wistar rats were divided into nine groups. Control groups received a saline solution for 30 days (C30) and 60 days (C60), and pilocarpine (PILO) for 60 days. Experimental groups received lorazepam (L30) and midazolam (M30) for 30 days. Another group (LS60 or MS60) received lorazepam or midazolam for 30 days, respectively, and saline for additional 30 days. Finally, other groups (LP60 or MP60) received either lorazepam or midazolam for 30 days, respectively, and pilocarpine for additional 30 days. The expression of calponin in myoepithelial cells and the proliferating cell nuclear antigen (PCNA) in acinar and ductal cells were evaluated.Results: Animals treated with lorazepam showed an increase in the number of positive staining cells for calponin as compared to control animals (p Conclusion: We found that myoepithelial cells might be more sensitive to the effects of BZD than acinar and ductal cells in rat parotid glands.
Effects of ecologically relevant concentrations of cadmium in a freshwater fish Letícia da Silva Pereira; SILVA DE ASSIS, H.C.; RIBAS, J.L.C.; Taynah Vicari; SILVA, S.B.; STIVAL, J.; BALDAN, A.P.; VALDEZ DOMINGOS, F.X.; Marco Tadeu Grassi; Cestari, M.M. Ecotoxicology and Environmental Safety, v. 130, p. 29-36, 2016 DOI Palavra-chave: Genotoxicidade; micronúcleo; Alterações Morfológicas Nucleares; Rhamdia quelen; jundiá Áreas do conhecimento: Ciências Biológicas; Farmacologia; toxicidade em peixes; Ciências Biológicas; Ecologia; Ecologia Aplicada; Ecotoxicologia; Ciências Biológicas; Genética; Genotoxicidade em Peixes resumo ...
Effects of ecologically relevant concentrations of cadmium in a freshwater fish PEREIRA, L.S.; Helena Cristina da Silva de Assis; João Luiz Coelho Ribas; VICARI, T.; SILVA, S.B.; STIVAL, J.; BALDAN, A.P.; VALDEZ DOMINGOS, F.X.; GRASSI, M.T.; Cestari, M.M. Ecotoxicology and Environmental Safety, v. 130, p. 29-36, 2016 DOI Palavra-chave: metais; biomarcadores resumo ...
Effects of realistic concentrations of TiO2 and ZnO nanoparticles in Prochilodus lineatus juvenile fish Renata Rank Miranda; FILIPAK NETO, F.; DAMASO DA SILVEIRA, A. L. R.; DE JESUS, I. P.; GRÖTZNER, S. R.; Carmen Lúcia Voigt; CAMPOS, S. X.; GARCIA, J. R. E.; M. A. F. Randi; C A Oliveira Ribeiro Environmental Science and Pollution Research International, v. 23, n. 6, p. 5179-5188, 2016 DOI Palavra-chave: nanopartículas; Estresse Oxidativo; citotoxicidade; neurotoxicidade Áreas do conhecimento: Ciências Biológicas; Morfologia; Citologia e Biologia Celular; Ciências Biológicas; Ecologia; Ecologia Aplicada resumo ... The impact of nanoparticles on fish health is still a matter of debate, since nanotechnology is quite recent. In this study, freshwater benthonic juvenile fish Prochilodus lineatus were exposed through water to three concentrations of TiO2 (0.1, 1, and 10 μg l−1) and ZnO (7, 70, and 700 μg l−1) nanoparticles, as well as to a mixture of both (TiO2 1 μg l−1 + ZnO 70 μg l−1) for 5 and 30 days. Nanoparticle characterization revealed an increase of aggregate size in the function of concentration, but suspensions were generally stable. Fish mortality was high at subchronic exposure to 70 and 700 μg l−1 of ZnO. Nanoparticle exposure led to decreased acetylcholinesterase activity either in the muscle or in the brain, depending on particle composition (muscle—TiO2 10 μg l−1; brain—ZnO 7 and 700 μg l−1), and protein oxidative damage increased in the brain (ZnO 70 μg l−1) and gills (ZnO 70 μg l−1 and mixture) but not in the liver. Exposed fish had more frequent alterations in the liver (necrosis, vascular congestion, leukocyte infiltration, and basophilic foci) and gills (hyperplasia and epithelial damages, e.g., epithelial disorganization and epithelial loss) than the control fish. Thus, predicted concentrations of TiO2 and ZnO nanoparticles caused detectable effects on P. lineatus that may have important consequences to fish health. But, these effects are much more subtle than those usually reported in the scientific literature for high concentrations or doses of metal nanoparticles.
Effects of realistic concentrations of TiO2 and ZnO nanoparticles in Prochilodus lineatus juvenile fish MIRANDA, R. R.; Filipak Neto, Francisco; DAMASO DA SILVEIRA, A. L. R.; Izabela Paulini de Jesus; Sonia Grötzner; VOIGT, C. L.; CAMPOS, S. X.; GARCIA, J. R. E.; Marco Antonio Ferreira Randi; RIBEIRO, C. A. OLIVEIRA Environmental Science and Pollution Research, v. 23, n. 6, p. 5179-5188, 2016 DOI Home page Palavra-chave: Metaloxide nanoparticle; fish; oxidative stress; cytotoxicity; Neurotoxicity Áreas do conhecimento: Ciências Biológicas; Histologia; Ciências Biológicas; Morfologia; Autometalografia; Ciências Biológicas; Morfologia; Ultraestrutura resumo ... The impact of nanoparticles on fish health is still a matter of debate, since nanotechnology is quite recent. In this study, freshwater benthonic juvenile fish Prochilodus lineatus were exposed through water to three concentrations of TiO2 (0.1, 1, and 10 μg l−1) and ZnO (7, 70, and 700 μg l−1) nanoparticles, as well as to a mixture of both (TiO2 1 μg l−1 + ZnO 70 μg l−1) for 5 and 30 days. Nanoparticle characterization revealed an increase of aggregate size in the function of concentration, but suspensions were generally stable. Fish mortality was high at subchronic exposure to 70 and 700 μg l−1 of ZnO. Nanoparticle exposure led to decreased acetylcholinesterase activity either in the muscle or in the brain, depending on particle composition (muscle—TiO2 10 μg l−1; brain—ZnO 7 and 700 μg l−1), and protein oxidative damage increased in the brain (ZnO 70 μg l−1) and gills (ZnO 70 μg l−1 and mixture) but not in the liver. Exposed fish had more frequent alterations in the liver (necrosis, vascular congestion, leukocyte infiltration, and basophilic foci) and gills (hyperplasia and epithelial damages, e.g., epithelial disorganization and epithelial loss) than the control fish. Thus, predicted concentrations of TiO2 and ZnO nanoparticles caused detectable effects on P. lineatus that may have important consequences to fish health. But, these effects are much more subtle than those usually reported in the scientific literature for high concentrations or doses of metal nanoparticles.
EFFECTS OF RESISTIVE EXERCISE AND STRETCHING ON THE SOLEUS MUSCLE OF OVARIECTOMIZED RATS Julye L. Ywazaki; LOUREIRO, ANA PAULA CUNHA; Talita Gianello Gnoato Zotz; Luana Ribeiro Nascimento; Douglas Vizzu Nobre; Anna Raquel Silveira Gomes Fisioterapia e Pesquisa, v. 23, n. 1, p. 74-83, 2016 Palavra-chave: Muscular stretching exercise; exercise; Musculoskeletal system; Sarcopenia; rats Áreas do conhecimento: Ciências da Saúde; Farmacologia; Transmissão Neuromuscular; Ciências da Saúde; Educação Física; História do Esporte; Ciências Biológicas; Morfologia resumo ...
Employing photoacoustic spectroscopy in the evaluation of the skin permeation profile of emulsion containing antioxidant phenolic-rich extract of Melochia arenosa TUNIN, LUANA MAGRI; BORGHI, FERNANDA BELINCANTA; Ana Claudia Nogueira Mulati; HIGACHI, LUCIANA; BARBOSA, DÉCIO SABBATINI; Mauro Luciano Baesso; HERNANDES, LUZMARINA; DINIZ, ANDRÉA; TORRADO TRUITI, MARIA DA CONCEIÇÃO PHARMACEUTICAL BIOLOGY, v. xx, p. 1-7, 2016 DOI Palavra-chave: Fotoacústica; Difusão de medicamentos na pele resumo ... Context: Oxidative stress is an important factor modulating skin alterations. Melochia arenosa Benth. (Malvaceae) is a Brazilian plant with antimicrobial activity and antioxidant potential.Objectiv...
Environmentally Relevant Concentrations of TiO2 Nanoparticles Affected Cell Viability and Photosynthetic Yield in the Chlorophyceae Scenedesmus bijugus Daniela Mariano Barreto; Ana Teresa Lombardi Water, Air and Soil Pollution (Print), v. 227, p. 450-460, 2016 DOI Palavra-chave: nanoparticula metalica; microalga; fisiologia alga; fotssintese Áreas do conhecimento: Ciências Biológicas; ECOTOXICOLOGIA; Ciências Biológicas; Botânica; Fisioecologia de microalgas resumo ...
Enzymatic kinetic resolution of aliphatic sec-alcohols by LipG9, a metagenomic lipase Pamela Taisline Bandeira; Robson Carlos Alnoch; Alfredo Ricardo Marques de Oliveira; Emanuel Maltempi de Souza; Fábio de Oliveira Pedrosa; KRIEGER, NADIA; Leandro Piovan Journal of Molecular Catalysis. B, Enzymatic (Print), v. 125, p. 58-63, 2016 DOI Palavra-chave: lipase; enantiosseletividade; metagenômica; Biocatálise; Resolução de misturas racêmicas Áreas do conhecimento: Ciências Exatas e da Terra; Química Orgânica; Síntese Orgânica; Ciências Biológicas; Bioquímica; Bioquímica dos Microorganismos; Biotecnologia; Ciências Biológicas; Bioquímica; Enzimologia resumo ...
ESTUDO DE MERCADO SOBRE O CONSUMO DE CAMARÕES NA REGIÃO OESTE DO PARANÁ Jorge Alab; Eric Lucas Dalpiaz; Eduardo Luis Cupertino Ballester Extensão em Foco (Curitiba), v. 12, n. 1, p. 32-41, 2016 Palavra-chave: Aquicultura; Carcinicultura; Mercado Áreas do conhecimento: CIENCIAS_AGRARIAS; Aqüicultura; Ciências Biológicas; Biologia Geral; Aquacultura; Carcinicultura resumo ...

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