Publicações - ciências biológicas
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Mariana Furtado Bergmann;
Jeferson M. B. Sohn;
Ana Maria Raymundi;
Manoela de Aguiar Ferreira;
Cristina Aparecida Jark Stern
Palavra-chave:
Córtex pré-frontal;
epigenética;
Histonas;
Memória;
PTSD
Áreas do conhecimento:
Ciências Biológicas; Farmacologia; Neuropsicofarmacologia
resumo ...
Reconsolidation, a memory stabilization phase occurring after reactivation, depends on epigenetic mechanisms such as histone acetylation, mediated by histone acetyltransferases (HATs) like p300/CBP. The prelimbic (PL) region of the medial prefrontal cortex is involved in fear memory reconsolidation, whereas the infralimbic (IL) cortex supports memory extinction. In the PL cortex, epigenetic mechanisms mediated by HAT CBP have been implicated in fear discrimination. However, the role of HAT p300/CBP in PL and IL cortices during contextual fear memory reconsolidation is unknown. To investigate this, fear-conditioned animals received intra-PL or IL cortices administration of C646 (5 or 50 ng/0.2uL/side), a HAT p300/CBP inhibitor, immediately, 1 h, or 6 h after memory reactivation. In the PL cortex, C646 (50 ng) administered within 1 h post-reactivation disrupted reconsolidation, evidenced by reduced freezing in Test A1 (24 h) and Test A2 (7 days). In the PL cortex, HAT p300/CBP inhibition 1 h post-retrieval significantly reduced freezing behavior in Test B1. No effects were observed in the IL cortex. The effects of C646 50 ng administered into the PL cortex depended on memory reactivation and were unrelated to alterations in anxiety-like behavior or locomotor activity. Confirming the post-retrieval involvement of histone acetylation, an enhancement of histone H3 acetylation in the PL was observed 120 min after reactivation in vehicle-treated animals, while C646 (50 ng) prevented this effect. These findings demonstrate the involvement of HAT p300/CBP in the PL cortex in memory reconsolidation, suggesting that, in this area, fear memory reconsolidation is regulated by epigenetic mechanisms.
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MAGRI, RENATO A;
LUEBERT, FEDERICO;
CABRAL, ANDRESSA;
ALCANTARA, SUZANA;
LOHMANN, LÚCIA G;
Jefferson Prado;
LOPES, JENIFER C
Palavra-chave:
Andes;
Atlantic Forest;
Bayesian inference;
Monocotyledons;
Phylogeny;
South America
Áreas do conhecimento:
Ciências Biológicas; Botânica; Taxonomia Vegetal; Taxonomia de Fanerógamos
resumo ...
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JUSTI, KATIA;
Ângelo Parise Pinto
Palavra-chave:
Aquatic insects;
Atlantic Forest;
Neotropical region;
New record;
Systematics
resumo ...
ABSTRACT In this study, we revisited the taxonomy of three southern endemic Brazilian species of...
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DE LARA, GABRIEL BOCCHETTI;
MÓGOR, GILDA;
MÓGOR, ÁTILA FRANCISCO;
LIMA, GUIUSEPPINA PACE PEREIRA;
AMATUSSI, JULIANA OLIVEIRA;
Ricardo Augusto de Oliveira;
João Carlos Bespalhok Filho
Palavra-chave:
Biostimulant;
polyamines;
Tryptamine;
Chlorophyceae
resumo ...
The use of one-bud propagules (OBP) as a sugarcane planting technique is widespread because of logistic advantages. Propagules from different culm positions have different physiological ages, and present different sprouting and early growth rates, which is an issue for the uniformity of the stand. Therefore, this study aimed to investigate the effect of OBP immersion in a microalga biomass extract rich in L-free amino acids, looking for a natural alternative to hazardous chemical treatments to stimulate sugarcane sprouting and plant growth. Immersion of OBP for 30 min in a 2.5 g L−1 solution of the chlorophyte microalga Asterarcys quadricellularis (AQ) improved the sprouting rate of propagules from all culm positions, the effect being most evident in the medial position. Biochemical changes involving sugar levels, and especially the bioactive amines (polyamines and indoleamines), reduced putrescine content, and improved tryptophan content of OBP. Immersion in AQ also enhanced the early growth of sugarcane, with 50-day-old plants presenting gains in culm length and diameter, increments in leaf area, and fresh mass, variably depending on the OBP position. The biometrical gains also followed biochemical changes, increasing the serotonin content of leaves. The results could be related, at least in part, to the L-free amino acid content in microalga biomass, triggering the bioactive amines as key metabolites related to the microalga growth-promoting effect. This study also provides relevant information for developing a field technique to improve and unify sugarcane sprouting and initial growth in an eco-friendly way.
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JUSTA, HANNA CÂMARA DA;
MINOZZO, JOÃO CARLOS;
GREMSKI, LUIZA HELENA;
Veiga, Silvio S.;
BALDISSERA, ANTONIELLE BEATRIZ;
MACHADO, MARIANA IZABELE;
SOUZA, SAMIRA HAJJAR;
POLLI, NAYANNE LOUISE COSTACURTA;
Bóia-Ferreira, Marianna;
SCHLUGA, PEDRO HENRIQUE DE CAIRES;
Donatti, Lucélia;
WILLE, ANA CAROLINA M.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS,
v. 1870,
n. 2,
p. 159579
2025
DOI
Palavra-chave:
phospholipases D;
Loxosceles venoms;
Endothelial Cell
Áreas do conhecimento:
Ciências Biológicas; Morfologia;
Ciências Biológicas; Bioquímica; Bioquímica
resumo ...
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Nicholas J. Turland;
Sandra Knapp;
Wolf-Henning Kusber;
De-Zhu Li;
Tom W. May;
Anna M. Monro;
Jefferson Prado;
Michele J, Price;
Gideon F. Smith;
Juan Carlos Zamora Señoret;
WIERSEMA, JOHN H.;
Fred R. Barrie;
Kanchi N, Gandhi;
Julia Gravendyck;
Werner Greuter;
David Hawksworth;
Patrick S. Herendeen;
Ronell R. Klopper
Palavra-chave:
Binding decision;
Botanical Code;
Conservation of names;
Principles;
Rejection of names
Áreas do conhecimento:
Ciências Biológicas; Botânica; Nomenclatura Botânica
resumo ...
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BETTIM, ARIANE LIMA;
MAROCHI, MURILO ZANETTI;
Maria Angélica Haddad
Palavra-chave:
biofouling;
Hydrozoa;
introduced species;
Brasil
Áreas do conhecimento:
Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes;
Ciências Biológicas; Ecologia; Ecologia de Ecossistemas
resumo ...
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DE OLIVEIRA, MÁRCIO LEITE;
DUARTE, JOSÉ MAURÍCIO BARBANTI;
Fernando C. Passos;
GROTTA'NETO, FRANCISCO;
DA SILVA, AMANDA ROSA;
PINHO, MANOELA EBNER;
RIBEIRO, RULLIAN CÉSAR;
DE CORREIA JUNIOR, ANTÔNIO ALMEIDA;
JEROZOLIMSKI, RICARDO;
DE PERES, PEDRO HENRIQUE FARIA;
VOGLIOTTI, ALEXANDRE
Palavra-chave:
Ungulates;
Mammals;
anthropogenic influences
resumo ...
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GUILHERME, GABRIELLE OLIVEIRA;
FERREIRA, MATHEUS VINICIUS;
COSTA, JADERSON PEDRO BONFIM DA;
LIEBL, BRUNO;
VERRI, WALDICEU APARECIDO;
ZANOVELI, JANAINA MENEZES;
Cunha, Joice M.
Palavra-chave:
estreptozotocina;
diabetes;
neuropatia diabética;
lipideos pró-resolução
Áreas do conhecimento:
Ciências Biológicas; Bioquímica; Farmacologia da Dor; Hiperalgesia Inflamatória
resumo ...
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DANTAS, KASSYO L. S.;
CLISSA, PATRICIA B.;
CASAGRANDE, RUBIA;
VERRI, WALDICEU A.;
BIANCHINI, BEATRIZ H. S.;
DA SILVA, MATHEUS D. V.;
PIVA, MAIARA;
Cunha, Joice M.;
Janaina Menezes Zanoveli;
CARDOSO, FERNANDA C.;
VICENTINI, FABIANA T. M. C.;
FERRAZ, CAMILA R.
Palavra-chave:
lipideos pró-resolução;
dor inflamatória
resumo ...
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