Publicações - ciências biológicas
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Leonardo Polizeli Aguiar;
Pinto, Ângelo P.;
Ângelo Parise Pinto
Palavra-chave:
Araucaria Forest;
Blattaria;
Blaberinae;
New Species;
Systematics;
Zetoborinae
Áreas do conhecimento:
Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes;
Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes
resumo ...
The taxonomically intricate genus of trilobite cockroaches, Parahormetica Brunner von Wattenwyl, 1865, is revised based on a comparative morphological analysis. The goals of this study are to review the nomenclature, propose hypotheses about specific delimitation, and provide diagnoses to allow identification of the taxonomic units in the genus. Based on the revised status of Parahormetica, we transferred Parahormetica hylaeceps Miranda-Ribeiro, 1936, and Parahormetica punctata Saussure, 1873, to the genus Bionoblatta Rehn, 1940. Therefore, the genus includes now four species of giant cockroaches which are predominantly distributed on the Atlantic Forest: Parahormetica bilobata (Saussure, 1864), Parahormetica cicatricosa Saussure, 1869, Parahormetica monticollis (Burmeister, 1838), and Parahormetica museunacional sp. nov. (holotype male deposited in DZUP: Brazil, Paraná). Diagnoses, key, distribution maps, images of living, non-type, and type specimens are made available. Our results make clear that the status and limits among Brachycolini genera pending a full revision.
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RODRIGUES, ANA CAROLINA;
ADAMOSKI, DOUGLAS;
Daniela Fiori Gradia;
DE OLIVEIRA, JAQUELINE CARVALHO
Palavra-chave:
transcribed ultraconserved regions;
cancer;
Biomarkers
Áreas do conhecimento:
Ciências Biológicas; Genética; Genética Animal
resumo ...
Abstract. Ultraconserved regions (UCRs), encompassing 481 genomic segments identical across humans, mice, and rats, and conserved in other species, are distributed across all human chromosomes except 21 and Y. Over 90% of these regions, termed transcribed ultraconserved regions (T-UCRs) are expressed in at least one human tissue. Although extensively studied in the context of cancer since their discovery, the prognostic significance of T-UCRs in a pan-cancer context has not been explored. For this, TCGA data extracted from the TANRIC platform was utilized, differential expression and survival analysis was performed on different tumor types. Our analysis revealed that approximately 300 UCRs were expressed in the majority of the 20 tumor tissues. Additionally, it was noted that all examined tumor tissues expressed a higher number of UCRs compared to their non-tumor counterparts. Through t-distributed stochastic neighbor embedding (t-SNE) analysis, UCR expression patterns could distinguish primary tumor origins and types. Regarding the prognostic value, we identified 100 (20,8%) T-UCRs associated with disease-specific survival (DSS) and 102 (21.2%) T-UCRs associated with progression-free interval (PFI). Those T-UCRs are particularly important in the survival outcomes of kidney renal clear cell carcinoma (KIRC) and low-grade gliomas (LGC). In addition, we verified that uc.44, uc.48, uc.135, uc.144, uc.153, uc.217, uc.255, uc.256, uc.344, uc.357, uc.390, uc.427 and uc.436 were associated with survival of more than one tumor. Particularly, uc.135 high expression was associated with poor prognosis in Kidney Renal Papillary Cell Carcinoma (KIRP) and LGC, and good prognosis in KIRC. Uc.135 are mapped on MECOM gene, coding an oncoprotein acting as transcriptional regulator and involved in apoptosis, proliferation, and cell differentiation. Our findings suggest that analysis of T-UCRs expression have the potential to be used as predictive biomarkers and can help in studying the mechanisms and specific roles of the highlighted T-UCRs in cancer.Citation Format: Ana Carolina Rodrigues, Douglas Adamoski, Daniela F. Gradia, Jaqueline Carvalho de Oliveira. Transcribed ultraconserved regions are associated with survival in multiple tumor types [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3681.
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DE MARCHI, MICHELI;
MOGGIO, ERICK LAURENT;
DA LUZ, JESSICA ZABLOCKI;
Patricia Manuit Brito;
Silvana Sandri;
Sandra Helena Poliselli Farsky;
Stelee M P Biscaia;
Francisco Filipack Neto;
C A Oliveira Ribeiro
Palavra-chave:
BDE - 209;
Melanoma murino;
Prognóstico do cancer;
Toxicologia celular;
Saúde Pública
Áreas do conhecimento:
Ciências da Saúde; Saúde Pública;
Ciências Biológicas; Ecologia; Ecologia Aplicada
resumo ...
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HASEYAMA, KIRSTERN LICA FOLLMANN;
BOIARSKI, MARIA CAROLINA ROMAGNA;
Elaine Della Giustina Soares;
NIHEI, SILVIO S.;
Cláudio J B Carvalho
Palavra-chave:
Atlantic Forest;
identification key;
Neotropical;
Phylogeny;
Taxonomy
Áreas do conhecimento:
Ciências Biológicas; Bioquímica dos Microorganismos; Enzimologia;
Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes;
Ciências Biológicas; Zoologia; Biogeografia
resumo ...
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SULZBACH DENARDIN, MAIARA;
PFÖHLER, CLAUDIA;
WORM, MARGITTA;
VAN BEEK, NINA;
GOEBELER, MATTHIAS;
SÁRDY, MIKLÓS;
IBRAHIM, SALEH;
BUSCH, HAUKE;
SCHMIDT, ENNO;
HUNDT, JENNIFER ELISABETH;
Petzl-Erler, Maria Luiza;
BUMILLER-BINI HOCH, VALÉRIA;
Angelica Beate Winter Boldt;
SALVIANO-SILVA, AMANDA;
LOBO-ALVES, SARA CRISTINA;
ADELMAN CIPOLLA, GABRIEL;
MALHEIROS, DANIELLE;
Augusto, Danillo G.;
WITTIG, MICHAEL;
FRANKE, ANDRE
Palavra-chave:
HDAC;
modificações das histonas;
HAT;
epigenética;
pênfigo foliáceo;
PHF21A
Áreas do conhecimento:
Ciências Biológicas; Genética Humana e Médica;
Ciências Biológicas; Genética; Epigenética
resumo ...
Pemphigus foliaceus (PF) is an autoimmune skin blistering disease characterized by antidesmoglein-1 IgG production, with an endemic form (EPF) in Brazil. Genetic and epigenetic factors have been associated with EPF, but its etiology is still not fully understood. To evaluate the genetic association of histone (de)acetylation-related genes with EPF susceptibility, we evaluated 785 polymorphisms from 144 genes, for 227 EPF patients and 194 controls. Carriers of HDAC4_rs4852054*A were more susceptible (OR = 1.79, p = 0.0038), whereas those with GSE1_rs13339618*A (OR = 0.57, p = 0.0011) and homozygotes for PHF21A_rs4756055*A (OR = 0.39, p = 0.0006) were less susceptible to EPF. These variants were not associated with sporadic PF (SPF) in German samples of 75 SPF patients and 150 controls, possibly reflecting differences in SPF and EPF pathophysiology. We further evaluated the expression of histone (de)acetylation-related genes in CD4+ T lymphocytes, using RNAseq. In these cells, we found a higher expression of KAT2B, PHF20, and ZEB2 and lower expression of KAT14 and JAD1 in patients with active EPF without treatment compared to controls from endemic regions. The encoded proteins cause epigenetic modifications related to immune cell differentiation and cell death, possibly affecting the immune response in patients with PF.
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DA SILVA, ANA PAULA;
de Castilhos Ghisi, Nédia;
POQUIOMA HERNÁNDEZ, HILDA VANESSA;
COMELLI, CAMILA LUIZA;
GUILLÉN PORTUGAL, MIGUEL ANGEL;
MOREIRA DELAVY, FERNANDA;
DE SOUZA, TUGSTENIO LIMA;
DE OLIVEIRA, ELTON CELTON;
C A Oliveira Ribeiro;
Helena Cristina da Silva de Assis
Palavra-chave:
meta-analise;
mechanismo antioxidante;
Peixes
Áreas do conhecimento:
Ciências Biológicas; Ecologia Aplicada; Ecotoxicologia
resumo ...
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STAKOWIAN, NICOLE;
Carolina Arruda de Oliveira Freire
Palavra-chave:
osmoregulation;
Bivalvia;
Cyrtopleura
Áreas do conhecimento:
Ciências Biológicas; Fisiologia Comparada; Fisiologia Comparativa da Osmorregulação
resumo ...
ABSTRACT. Cyrtopleura costata is a pholadid bivalve that inhabits tidal flats inside burrows c. 40 cm deep, and its visceral mass outgrows its shell signif
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ZABLOCKI DA LUZ, J.;
LIMA DE SOUZA, T.;
DE ALMEIDA ROQUE, A.;
OPUSKEVITCH, I.;
ALVES DA SILVA FERREIRA, F. C.;
MELA PRODOCIMO, M.;
C A Oliveira Ribeiro;
Filipak Neto, Francisco
Palavra-chave:
Toxicologia celular;
hepatocitos;
Oreochromis niloticus
Áreas do conhecimento:
Ciências Biológicas; Ecologia; Ecologia Aplicada;
Ciências Biológicas; Ecologia; Ecologia Aplicada; Ecotoxicologia
resumo ...
Risk assessment studies on aquatic pollution, a threat to water quality and aquatic biota, often rely on animal capture and experimentation. However, ethical concerns surrounding animal use have prompted the development and use of alternative methods. This study investigates the viability of primary hepatocyte cultures from Oreochromis niloticus as an in vitro tool for environmental contaminant screening, focusing on cadmium as a pollutant model. Isolated hepatocytes were cultured on plates using a mixture of supplemented L15/F12 media. Freezing conditions were tested for cell stock preservation. The cultured hepatocytes were exposed to 0.5, 5, and 50 µM of cadmium to assess cell viability, reactive oxygen and nitrogen species, and antioxidant molecules. Results demonstrated a concentration and time-dependent decrease in cell viability upon cadmium exposure. Cadmium exposure also induced an imbalance in the antioxidant defense system, leading to increased reactive oxygen species levels and lipid peroxidation. These findings validate the cadmium toxicity to primary hepatocytes and confirm the applicability of commonly used biomarkers in animal-based ecotoxicology and risk assessment studies. The replication of these biomarkers in primary hepatocyte cultures provides an ethical alternative to reduce animal testing in ecotoxicology. Lastly, the study highlights the potential of primary hepatocyte cultures as an in vitro tool for evaluating the toxicity of environmental contaminants and supports the integration of this tool in future environmental risk assessment studies, promoting sustainable water resource management while reducing reliance on animal experimentation.
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ANDRADE, BIANCA O.;
BENCKE, GLAYSON ARIEL;
BENEDUZI, ANELISE;
SILVA, JORGE BERNARDO;
BLOCHTEIN, BETINA;
BOLDRINI, ILSI IOB;
BOLL, PITER KEHOMA;
BORDIN, JUÇARA;
SILVEIRA, ROSA MARA BORGES DA;
MARTINS, MÁRCIO BORGES;
BOSENBECKER, CAMILA;
DROSE, WILLIAM;
BRACCINI, JOÃO;
AGUIAR, CASSIANA ALVES DE;
AIRES, ELISA TEIXEIRA;
ALVARES, DIEGO JANISCH;
BARBIERI, ROSA LIA;
Cláudio J B Carvalho;
BARTZ, MARIE;
BECKER, FERNANDO GERTUM
Palavra-chave:
animal diversity;
biogeographic survey;
Brazilian Pampa;
conservation;
open ecosystem
Áreas do conhecimento:
Ciências Biológicas; Bioquímica dos Microorganismos; Enzimologia;
Ciências Biológicas; Botânica; Fisiologia Vegetal;
Ciências Biológicas; Zoologia; Biogeografia
resumo ...
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Cláudio J B Carvalho;
Marcia Souto COURI
Palavra-chave:
Diptera;
Historical;
Dipterology
Áreas do conhecimento:
Ciências Biológicas; Zoologia
resumo ...
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