Publicações - ciências biológicas
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SOUZA, EDEILSON BRITO DE;
PRESTES, ROSI MARIA;
Maria Cecilia de Chiara Moço
Palavra-chave:
Ensino de Ciências;
Interdisciplinaridade
resumo ...
(en)
Contextualized teaching uses elements from students' daily routines to construct learning experiences that value local aspects; in botany teaching, this approach can overcome learning difficulties and encourage student leadership. The aim of this study was to investigate the pedagogical practices of teacher training regarding the approach to botanical content related to the Caatinga biome in scientific publications, as well as their potential contributions to contextualized learning about local plant diversity. To this end, a systematic bibliographic review was conducted, analyzing publications from 2013 to 2023 on the teaching of botany and the vegetation of the Caatinga in teacher training, with a total of 67 works examined using the Content Analysis method. The results indicated an increase in the number of publications, the integration of different areas of knowledge, and the diversification of teaching resources and contextualization strategies at different levels of education. The conclusion is that teacher training courses, both at the graduate and postgraduate levels, play a fundamental role in contextualizing the teaching of botany and spreading knowledge about local biodiversity.
(pt)
O ensino contextualizado utiliza elementos do cotidiano dos estudantes para construir aprendizagens que valorizam os aspectos locais; no ensino de botânica, essa abordagem pode superar dificuldades de aprendizagem e estimular o protagonismo discente. O objetivo deste estudo foi investigar as práticas pedagógicas da formação de professores quanto à abordagem de conteúdos botânicos relacionados ao bioma Caatinga em publicações científicas, bem como suas potenciais contribuições para uma aprendizagem contextualizada à diversidade vegetal local. Para isso, realizou-se uma pesquisa bibliográfica sistemática, analisando publicações de 2013 a 2023 sobre o ensino de botânica e a vegetação da Caatinga na formação docente, totalizando 67 trabalhos examinados por meio do método da Análise do Conteúdo. Os resultados indicaram um aumento no número das publicações, a integração de diferentes áreas do conhecimento e a diversificação dos recursos didáticos e estratégias de contextualização em distintos níveis de ensino. Conclui-se que os cursos de formação de professores, tanto na graduação quanto na pós-graduação, desempenham um papel fundamental na contextualização do ensino de botânica e na disseminação do conhecimento sobre a biodiversidade local.
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Stefani Michelon;
Fernando C. Passos;
Maria Martha Torres Martinez;
Luana dos Santos da Conceição;
Marina de Souza;
Henrique Gelinski;
Francisco Walison dos Santos Machi;
Isabela Pivetta Trentini;
Giovanna Giamberardino Bianchetti;
Juliana Paula de Souza
Palavra-chave:
Atropelamento de Fauna;
Ciência Cidadã;
Divulgação científica;
Ecologia de Estradas
resumo ...
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Ana Paula Yumi Nishimura;
Fernando Augusto Pedersen Voll;
KRIEGER, NADIA;
MITCHELL, DAVID ALEXANDER
Palavra-chave:
lipase;
Selectivity;
enzyme kinetics;
trimethylolpropane;
ping pong bi bi
Áreas do conhecimento:
Engenharias; Engenharia Química; Processos Industriais de Engenharia Química; Processos Bioquímicos;
Ciências Biológicas; Bioquímica; Enzimologia; Cinética Enzimática
resumo ...
Kinetic models are important tools for guiding the design and optimization of lipase-catalyzed processes. These processes follow the Ping Pong bi bi mechanism, for which mechanistic kinetic equations can be derived. However, when there are several competing reactions, fully mechanistic models contain a large number of parameters, making it difficult to obtain reliable estimates, so simplified models are necessary. We present a two-step approach to developing semi-mechanistic models of such processes. The first step involves the estimation of the selectivities of the enzyme, using profiles for the reaction species plotted against the degree of reaction, while the second step involves empirical fitting to the same data, but plotted as a function of time. We demonstrate this two-step approach through four case studies based on the literature data for the lipase-catalyzed esterification of fatty acids with trimethylolpropane to produce biolubricants. The semi-mechanistic models were able to describe the data well. Our approach has the advantage of allowing selectivities to be estimated without confounding effects from phenomena such as enzyme denaturation and inhibition. It therefore provides a promising framework for developing models of enzyme-catalyzed processes that obey Ping Pong bi bi kinetics.
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Matheus Henrique Hamann;
Matheus Oliveira Freitas;
Mauricio Osvaldo Moura;
Luis Roberto Bueno;
Vinícius Abilhoa
Palavra-chave:
distribuição geográfica;
Especiação;
Métodos Quantitativos;
morfometria
Áreas do conhecimento:
Ciências Biológicas; Ecologia; Ecologia de Comunidades
resumo ...
Abstract Species of Hoplias malabaricus complex group are widely distributed in most Neotropical...
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Pedro Bond Schwartsburd;
Jefferson Prado;
Regina Y. Hirai;
Paulo H. Labiak
Palavra-chave:
biodiversity;
Brazilian Atlantic Forest;
Cerrado;
endemism;
Goniophlebium
Áreas do conhecimento:
Ciências Biológicas; Botânica; Taxonomia Vegetal; Taxonomia de Criptógamos
resumo ...
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ALVES, ANA CAROLINA FELICIO;
PALACIO-CORTÉS, ANGELA M.;
VALENCIA-MARÍN, BRYAN STEVEN;
João Antonio Cyrino Zequi;
Mário Antonio NavarroSilva
Palavra-chave:
mudanças climáticas;
Culicidae;
Diptera;
Aedes;
Oviposição
Áreas do conhecimento:
Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes;
Ciências Biológicas; Zoologia; Fisiologia dos Grupos Recentes
resumo ...
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RADULSKI, DÉBORA RASEC;
GALINDO, CLAUDIA MARTINS;
DE SOUZA RAMOS, EDNEIA AMANCIO;
KLASSEN, GISELI;
Stefanello, Maria Élida Alves;
CHICHORRO, JULIANA GEREMIAS;
Acco, Alexandra;
PEREIRA, GABRIELA SAIDEL;
BAGGIO, DARCIANE FAVERO;
VERDAN, MARIA HELENA;
WINIEWSKI, VANESSA;
MALAQUIAS, LIZIANE CRISTINE;
VILANI, JÚLIA MILCZERWKI;
CARDOSO, GABRIELA CASANI;
STIPP, MARIA CAROLINA
Palavra-chave:
Sinningia;
ATIVIDADE ANTITUMORAL;
Naftoquinona
Áreas do conhecimento:
Ciências Exatas e da Terra; Química; Química Orgânica; Química dos Produtos Naturais;
Ciências Biológicas; Farmacologia; Farmacologia Geral
resumo ...
Breast cancer is the most frequent in women for both cases and deaths and at least half of patients report pain as a symptom. A previous phytochemical study with the tubers of the Sinningia reitzii (Hoehne) L.E.Skog (SR) led to the isolation of 8 naphthoquinones. Among them, the 6,7-dimethoxydunnione (SR4) showed antitumor activity in vitro. This study aimed to evaluate the antitumor and analgesic potential of SR components against Ehrlich carcinoma in Swiss female mice, and in MCF-7 and HB4a breast cell lineages. Mice were inoculated with tumor cells and treated daily with SR extract, namely dichloromethane fraction (ESR, 10, 30 and 100 mg kg− 1), SR4 (3 mg kg− 1) or vehicle, orally; or with the methotrexate chemotherapy (2.5 mg kg− 1) via i.p., every 3 days, along 21 days. Both ESR and SR4 induced toxicity in the tumor cell MCF-7 but did not in non-tumor human breast cell HB4a in culture. ESR and SR4 showed antitumor effects, but ESR showed more expressive results. The ESR caused changes in the oxidative balance in the tumor tissue and decreased myeloperoxidase levels without reducing the levels of pro-inflammatory cytokines. ESR induced necrosis in tumor and increased the gene expression of Ripk1, which is involved in the necroptosis pathway. In addition, ESR showed acute, but not cumulative, analgesic effect in pain associated with Ehrlich cells inoculation in the mice paw. The components of Sinningia reitzii, mainly the ESR, are promising sources of drugs that combine analgesic and antitumor effects, without systemic toxicity.
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RADULSKI, DÉBORA RASEC;
GALINDO, CLAUDIA MARTINS;
DE SOUZA RAMOS, EDNEIA AMANCIO;
Giseli Klassen;
STEFANELLO, MARIA ÉLIDA ALVES;
CHICHORRO, JULIANA GEREMIAS;
ACCO, ALEXANDRA;
PEREIRA, GABRIELA SAIDEL;
BAGGIO, DARCIANE FAVERO;
VERDAN, MARIA HELENA;
WINIEWSKI, VANESSA;
MALAQUIAS, LIZIANE CRISTINE;
VILANI, JÚLIA MILCZERWKI;
CARDOSO, GABRIELA CASANI;
STIPP, MARIA CAROLINA
Palavra-chave:
Antineoplásicos;
Câncer de mama
Áreas do conhecimento:
Ciências Biológicas; Biologia Molecular do Câncer
resumo ...
Breast cancer is the most frequent in women for both cases and deaths and at least half of patients report pain as a symptom. A previous phytochemical study with the tubers of the Sinningia reitzii (Hoehne) L.E.Skog (SR) led to the isolation of 8 naphthoquinones. Among them, the 6,7-dimethoxydunnione (SR4) showed antitumor activity in vitro. This study aimed to evaluate the antitumor and analgesic potential of SR components against Ehrlich carcinoma in Swiss female mice, and in MCF-7 and HB4a breast cell lineages. Mice were inoculated with tumor cells and treated daily with SR extract, namely dichloromethane fraction (ESR, 10, 30 and 100 mg kg− 1), SR4 (3 mg kg− 1) or vehicle, orally; or with the methotrexate chemotherapy (2.5 mg kg− 1) via i.p., every 3 days, along 21 days. Both ESR and SR4 induced toxicity in the tumor cell MCF-7 but did not in non-tumor human breast cell HB4a in culture. ESR and SR4 showed antitumor effects, but ESR showed more expressive results. The ESR caused changes in the oxidative balance in the tumor tissue and decreased myeloperoxidase levels without reducing the levels of pro-inflammatory cytokines. ESR induced necrosis in tumor and increased the gene expression of Ripk1, which is involved in the necroptosis pathway. In addition, ESR showed acute, but not cumulative, analgesic effect in pain associated with Ehrlich cells inoculation in the mice paw. The components of Sinningia reitzii, mainly the ESR, are promising sources of drugs that combine analgesic and antitumor effects, without systemic toxicity.
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RADULSKI, DÉBORA RASEC;
GALINDO, CLAUDIA MARTINS;
Edneia Amancio de Souza Ramos Cavalieri;
Giseli Klassen;
STEFANELLO, MARIA ÉLIDA ALVES;
CHICHORRO, JULIANA GEREMIAS;
ACCO, ALEXANDRA;
PEREIRA, GABRIELA SAIDEL;
BAGGIO, DARCIANE FAVERO;
VERDAN, MARIA HELENA;
WINIEWSKI, VANESSA;
MALAQUIAS, LIZIANE CRISTINE;
VILANI, JÚLIA MILCZERWKI;
CARDOSO, GABRIELA CASANI;
STIPP, MARIA CAROLINA
Palavra-chave:
Breast cancer;
Molecular marker
Áreas do conhecimento:
Ciências Biológicas; Biologia Geral; Pathology
resumo ...
Breast cancer is the most frequent in women for both cases and deaths and at least half of patients report pain as a symptom. A previous phytochemical study with the tubers of the Sinningia reitzii (Hoehne) L.E.Skog (SR) led to the isolation of 8 naphthoquinones. Among them, the 6,7-dimethoxydunnione (SR4) showed antitumor activity in vitro. This study aimed to evaluate the antitumor and analgesic potential of SR components against Ehrlich carcinoma in Swiss female mice, and in MCF-7 and HB4a breast cell lineages. Mice were inoculated with tumor cells and treated daily with SR extract, namely dichloromethane fraction (ESR, 10, 30 and 100 mg kg− 1), SR4 (3 mg kg− 1) or vehicle, orally; or with the methotrexate chemotherapy (2.5 mg kg− 1) via i.p., every 3 days, along 21 days. Both ESR and SR4 induced toxicity in the tumor cell MCF-7 but did not in non-tumor human breast cell HB4a in culture. ESR and SR4 showed antitumor effects, but ESR showed more expressive results. The ESR caused changes in the oxidative balance in the tumor tissue and decreased myeloperoxidase levels without reducing the levels of pro-inflammatory cytokines. ESR induced necrosis in tumor and increased the gene expression of Ripk1, which is involved in the necroptosis pathway. In addition, ESR showed acute, but not cumulative, analgesic effect in pain associated with Ehrlich cells inoculation in the mice paw. The components of Sinningia reitzii, mainly the ESR, are promising sources of drugs that combine analgesic and antitumor effects, without systemic toxicity.
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Lucas Santos Solidade;
Leonardo Faria;
Ana Teresa Lombardi
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,
v. 198,
p. 2806
2026
Palavra-chave:
Biomoleculas;
biotecnologia microalgas;
Culturas
Áreas do conhecimento:
Ciências Biológicas; Biotecnologia; Biotecnologia Ambiental e Recursos Naturais; Bioprospecção
resumo ...
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