Publicações - ciências biológicas
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Stefani Michelon;
Fernando C. Passos;
Maria Martha Torres Martinez;
Luana dos Santos da Conceição;
Marina de Souza;
Henrique Gelinski;
Francisco Walison dos Santos Machi;
Isabela Pivetta Trentini;
Giovanna Giamberardino Bianchetti;
Juliana Paula de Souza
Palavra-chave:
Atropelamento de Fauna;
Ciência Cidadã;
Divulgação científica;
Ecologia de Estradas
resumo ...
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Ana Paula Yumi Nishimura;
Fernando Augusto Pedersen Voll;
KRIEGER, NADIA;
MITCHELL, DAVID ALEXANDER
Palavra-chave:
lipase;
Selectivity;
enzyme kinetics;
trimethylolpropane;
ping pong bi bi
Áreas do conhecimento:
Engenharias; Engenharia Química; Processos Industriais de Engenharia Química; Processos Bioquímicos;
Ciências Biológicas; Bioquímica; Enzimologia; Cinética Enzimática
resumo ...
Kinetic models are important tools for guiding the design and optimization of lipase-catalyzed processes. These processes follow the Ping Pong bi bi mechanism, for which mechanistic kinetic equations can be derived. However, when there are several competing reactions, fully mechanistic models contain a large number of parameters, making it difficult to obtain reliable estimates, so simplified models are necessary. We present a two-step approach to developing semi-mechanistic models of such processes. The first step involves the estimation of the selectivities of the enzyme, using profiles for the reaction species plotted against the degree of reaction, while the second step involves empirical fitting to the same data, but plotted as a function of time. We demonstrate this two-step approach through four case studies based on the literature data for the lipase-catalyzed esterification of fatty acids with trimethylolpropane to produce biolubricants. The semi-mechanistic models were able to describe the data well. Our approach has the advantage of allowing selectivities to be estimated without confounding effects from phenomena such as enzyme denaturation and inhibition. It therefore provides a promising framework for developing models of enzyme-catalyzed processes that obey Ping Pong bi bi kinetics.
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Pedro Bond Schwartsburd;
Jefferson Prado;
Regina Y. Hirai;
Paulo H. Labiak
Palavra-chave:
biodiversity;
Brazilian Atlantic Forest;
Cerrado;
endemism;
Goniophlebium
Áreas do conhecimento:
Ciências Biológicas; Botânica; Taxonomia Vegetal; Taxonomia de Criptógamos
resumo ...
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RADULSKI, DÉBORA RASEC;
GALINDO, CLAUDIA MARTINS;
DE SOUZA RAMOS, EDNEIA AMANCIO;
Giseli Klassen;
STEFANELLO, MARIA ÉLIDA ALVES;
CHICHORRO, JULIANA GEREMIAS;
ACCO, ALEXANDRA;
PEREIRA, GABRIELA SAIDEL;
BAGGIO, DARCIANE FAVERO;
VERDAN, MARIA HELENA;
WINIEWSKI, VANESSA;
MALAQUIAS, LIZIANE CRISTINE;
VILANI, JÚLIA MILCZERWKI;
CARDOSO, GABRIELA CASANI;
STIPP, MARIA CAROLINA
Palavra-chave:
Antineoplásicos;
Câncer de mama
Áreas do conhecimento:
Ciências Biológicas; Biologia Molecular do Câncer
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Breast cancer is the most frequent in women for both cases and deaths and at least half of patients report pain as a symptom. A previous phytochemical study with the tubers of the Sinningia reitzii (Hoehne) L.E.Skog (SR) led to the isolation of 8 naphthoquinones. Among them, the 6,7-dimethoxydunnione (SR4) showed antitumor activity in vitro. This study aimed to evaluate the antitumor and analgesic potential of SR components against Ehrlich carcinoma in Swiss female mice, and in MCF-7 and HB4a breast cell lineages. Mice were inoculated with tumor cells and treated daily with SR extract, namely dichloromethane fraction (ESR, 10, 30 and 100 mg kg− 1), SR4 (3 mg kg− 1) or vehicle, orally; or with the methotrexate chemotherapy (2.5 mg kg− 1) via i.p., every 3 days, along 21 days. Both ESR and SR4 induced toxicity in the tumor cell MCF-7 but did not in non-tumor human breast cell HB4a in culture. ESR and SR4 showed antitumor effects, but ESR showed more expressive results. The ESR caused changes in the oxidative balance in the tumor tissue and decreased myeloperoxidase levels without reducing the levels of pro-inflammatory cytokines. ESR induced necrosis in tumor and increased the gene expression of Ripk1, which is involved in the necroptosis pathway. In addition, ESR showed acute, but not cumulative, analgesic effect in pain associated with Ehrlich cells inoculation in the mice paw. The components of Sinningia reitzii, mainly the ESR, are promising sources of drugs that combine analgesic and antitumor effects, without systemic toxicity.
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RADULSKI, DÉBORA RASEC;
GALINDO, CLAUDIA MARTINS;
Edneia Amancio de Souza Ramos Cavalieri;
Giseli Klassen;
STEFANELLO, MARIA ÉLIDA ALVES;
CHICHORRO, JULIANA GEREMIAS;
ACCO, ALEXANDRA;
PEREIRA, GABRIELA SAIDEL;
BAGGIO, DARCIANE FAVERO;
VERDAN, MARIA HELENA;
WINIEWSKI, VANESSA;
MALAQUIAS, LIZIANE CRISTINE;
VILANI, JÚLIA MILCZERWKI;
CARDOSO, GABRIELA CASANI;
STIPP, MARIA CAROLINA
Palavra-chave:
Breast cancer;
Molecular marker
Áreas do conhecimento:
Ciências Biológicas; Biologia Geral; Pathology
resumo ...
Breast cancer is the most frequent in women for both cases and deaths and at least half of patients report pain as a symptom. A previous phytochemical study with the tubers of the Sinningia reitzii (Hoehne) L.E.Skog (SR) led to the isolation of 8 naphthoquinones. Among them, the 6,7-dimethoxydunnione (SR4) showed antitumor activity in vitro. This study aimed to evaluate the antitumor and analgesic potential of SR components against Ehrlich carcinoma in Swiss female mice, and in MCF-7 and HB4a breast cell lineages. Mice were inoculated with tumor cells and treated daily with SR extract, namely dichloromethane fraction (ESR, 10, 30 and 100 mg kg− 1), SR4 (3 mg kg− 1) or vehicle, orally; or with the methotrexate chemotherapy (2.5 mg kg− 1) via i.p., every 3 days, along 21 days. Both ESR and SR4 induced toxicity in the tumor cell MCF-7 but did not in non-tumor human breast cell HB4a in culture. ESR and SR4 showed antitumor effects, but ESR showed more expressive results. The ESR caused changes in the oxidative balance in the tumor tissue and decreased myeloperoxidase levels without reducing the levels of pro-inflammatory cytokines. ESR induced necrosis in tumor and increased the gene expression of Ripk1, which is involved in the necroptosis pathway. In addition, ESR showed acute, but not cumulative, analgesic effect in pain associated with Ehrlich cells inoculation in the mice paw. The components of Sinningia reitzii, mainly the ESR, are promising sources of drugs that combine analgesic and antitumor effects, without systemic toxicity.
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Lucas Santos Solidade;
Leonardo Faria;
Ana Teresa Lombardi
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,
v. 198,
p. 2806
2026
Palavra-chave:
Biomoleculas;
biotecnologia microalgas;
Culturas
Áreas do conhecimento:
Ciências Biológicas; Biotecnologia; Biotecnologia Ambiental e Recursos Naturais; Bioprospecção
resumo ...
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FERREIRA-JÚNIOR, CARLOS ALBERTO;
ZAVATIN, DANILO ALVARENGA;
Jefferson Prado;
BRAGANÇA, GRACIELLE PEREIRA PIMENTA;
ISAIAS, ROSY MARY DOS SANTOS;
CABRAL, ANDRESSA;
SILVA, RENATO RAMOS
Palavra-chave:
campos rupestres;
conservation;
Espinhaço Setentrional;
Flora of Brazil;
Pandanales
Áreas do conhecimento:
Ciências Biológicas; Botânica; Taxonomia Vegetal; Taxonomia de Fanerógamos
resumo ...
(en)
Floristic surveys near Monte Azul, Minas Gerais, have revealed a magenta-flowered Barbacenia inhabiting rocky outcrops bearing prehistoric paintings. The new species resembles B. tomentosa and B. luzulifolia in phyllotaxy and hypanthium size but differs mainly by its vivid corolla and reduced corona. Here, named Barbacenia rupestris, the new species epithet refers both to its rupicolous habitat and the prehistoric paintings.
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NEUNDORF, ANANDA KARLA ALVES;
PADIAL, ANDRÉ ANDRIAN;
Donatti, Lucélia;
CÔRREA, ANA PAULA NASCIMENTO;
ZEPSON-CAPUCHO, JOÃO MATEUS;
RIUZIM, YARA TANI;
DE ASSIS TEIXEIRA DA SILVA, UBIRATÃ;
VITULE, JEAN RICARDO SIMÕES;
FÁVARO, LUIS FERNANDO;
CABRAL, ANA CAROLINE;
DE CASTRO MARTINS, CÉSAR
Palavra-chave:
microplastics;
fish;
antioxidant defenses;
Biomarkers
Áreas do conhecimento:
Ciências Biológicas; Ecologia; Ecologia de Ecossistemas;
Ciências Biológicas; Bioquímica; Bioquímica
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GLINSKI, ANDRESSA;
LUZ, JESSICA ZABLOCKI DA;
ROQUE, ALICIANE DE ALMEIDA;
DE SOUZA, TUGSTENIO LIMA;
BEZERRA JUNIOR, ARANDI GINANE;
DE OLIVEIRA, CAROLINA CAMARGO;
C A Oliveira Ribeiro;
Filipak Neto, Francisco
Palavra-chave:
citotoxicidade;
Nanopartícula de prata;
metais tóxicos;
macrófagos;
ecotoxicologia
Áreas do conhecimento:
Ciências Biológicas; Ecologia; Ecologia Aplicada;
Ciências Biológicas; Ecologia; Ecologia Aplicada; Ecotoxicologia
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Félix P Leiva;
Felix C. Mark;
Rafael Molina-Venegas;
Katharina Alter;
Carolina Arruda de Oliveira Freire;
A. Jan Hendriks;
Adam Hermaniuk;
Léon Serre-Fredj;
Milad Shokri;
Marcin Czarnoleski
Palavra-chave:
erythrocyte size;
fish
Áreas do conhecimento:
Ciências Biológicas; Morfologia; Microanatomia Animal
resumo ...
Size is a fundamental trait in biology, and cell size plays a key role in cellular functions, influencing physiological adaptations and evolutionary processes in living organisms. For decades, scientists have been fascinated by the considerable variation in cell sizes among animals, yet systematic efforts to compile such data have been scarce. To address this gap, we employed a systematic map approach to create ErythroCite, an open-source database of fish erythrocyte sizes. This comprehensive resource encompasses 1,764 records from 660 species among four major lineages: Actinopterygii, Chondrichthyes, Dipnoi, and Cyclostomata. Our findings reveal a remarkable 414-fold range in cell volume, with most studies on bony fishes and limited data on juveniles and earlier life stages. Life stage and sex were infrequently reported, but available data showed equal representation of adult of females and males. ErythroCite offers valuable insights for studies in macroecology, macrophysiology, comparative physiology, evolutionary biology and cell biology. We anticipate this resource will facilitate comparative approaches and meta-analyses, globally driving further exploration of erythrocyte diversity and function in fish.
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