Publicações - ciências biológicas
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Rafael A. Baggio;
MORETTI, CAROLINE B.;
BIALETZKI, ANDRÉA;
Walter Antonio Boeger
Palavra-chave:
genética de populacoes
Áreas do conhecimento:
Ciências Biológicas; Genética; Genética Animal
resumo ...
ABSTRACT The production of hybrids of the 'pintado', Pseudoplatystoma corruscans (Spix...
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Mendes, Daniel Augusto Gasparin Bueno;
BITTENCOURT, CHRISTIANE MEYRE DA SILVA;
ZUFFELLATO-RIBAS, KATIA CHRISTINA;
Assreuy, Jamil;
OTUKI, M;
CABRINI, D;
Soley, Bruna da Silva;
Arthur Prudente;
SPONCHIADO, GRAZIELA;
FERREIRA, BÁRBARA GUERREIRA ALPANDE;
DOS SANTOS, MATHEUS CORRÊA;
DE ANDRADE, AMANDA SOBREIRO MODESTO;
AMORIM, CLARISSA DE MEDEIROS;
BRESOLIN, TANIA MARI BELLÉ
Palavra-chave:
Sapium glandulatum;
medicinal plants;
skin inflammation;
Glucocorticoids;
EUPHORBIACEAE
Áreas do conhecimento:
Ciências Biológicas; Bioquímica dos Microorganismos; Enzimologia
resumo ...
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Mendes, Daniel Augusto Gasparin Bueno;
MEYRE-SILVA, CHRISTIANE;
ZUFFELLATO-RIBAS, KATIA CHRISTINA;
Assreuy, Jamil;
OTUKI, M;
Cabrini, Daniela de Almeida;
Soley, Bruna da Silva;
Arthur Prudente;
SPONCHIADO, GRAZIELA;
FERREIRA, BÁRBARA GUERREIRA ALPANDE;
DOS SANTOS, MATHEUS CORRÊA;
DE ANDRADE, AMANDA SOBREIRO MODESTO;
AMORIM, CLARISSA DE MEDEIROS;
BRESOLIN, TANIA MARI BELLÉ
Palavra-chave:
Sauim grandulatum;
skin inflammation;
topic antiinflammatory;
medicinal plants;
Glucocorticoids;
EUPHORBIACEAE
Áreas do conhecimento:
Ciências Biológicas; Patofisiologia e farmacologia de processos inflamatórios cutâneos
resumo ...
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DOS REIS LÍVERO, FRANCISLAINE APARECIDA;
DE PAULA WERNER, MARIA FERNANDA;
Acco, Alexandra;
DA SILVA, LUISA MOTA;
FERREIRA, DANIELE MARIA;
GALUPPO, LARISSA FAVARETTO;
BORATO, DEBORA GASPARIN;
PRANDO, THIAGO BRUNO LIMA;
Lourenço, Emerson Luiz Botelho;
Strapasson, Regiane Lauriano Batista;
Stefanello, Maria Élida Alves
Palavra-chave:
Asteraceae;
Baccharis;
atividade biológica
Áreas do conhecimento:
Ciências Exatas e da Terra; Química; Química Orgânica; Química dos Produtos Naturais;
Ciências Biológicas; Farmacologia; Farmacologia Geral
resumo ...
Ethanol is a psychoactive substance highly consumed around the world whose health problems include gastric lesions. Baccharis trimera is used in folk medicine for the treatment of gastrointestinal disorders. However, few studies have evaluated its biological and toxic effects. To validate the popular use of B. trimera and elucidate its possible antiulcerogenic and cytotoxic mechanisms, a hydroethanolic extract of B. trimera (HEBT) was evaluated in models of gastric lesions. Rats and mice were used to evaluate the protective and antiulcerogenic effects of HEBT on gastric lesions induced by ethanol, acetic acid, and chronic ethanol consumption. The effects of HEBT were also evaluated in a pylorus ligature model and on gastrointestinal motility. The LD50 of HEBT in mice was additionally estimated. HEBT was analyzed by nuclear magnetic resonance, and a high-performance liquid chromatography fingerprint analysis was performed. Oral HEBT administration significantly reduced the lesion area and the oxidative stress induced by acute and chronic ethanol consumption. However, HEBT did not protect against gastric wall mucus depletion and did not alter gastric secretory volume, pH, or total acidity in the pylorus ligature model. Histologically, HEBT accelerated the healing of chronic gastric ulcers in rats, reflected by contractions of the ulcer base. Flavonoids and caffeoylquinic acids were detected in HEBT, which likely contributed to the therapeutic efficacy of HEBT, preventing or reversing ethanol- and acetic acid-induced ulcers, respectively. HEBT antiulcerogenic activity may be partially attributable to the inhibition of free radical generation and subsequent prevention of lipid peroxidation. Our results indicate that HEBT has both gastroprotective and curative activity in animal models, with no toxicity.
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Baggio, R. A.;
Orélis-Ribeiro, R.;
Walter Antonio Boeger
Pesquisa Agropecuária Brasileira (1977. Impressa),
v. 51,
n. 10,
p. 1744-1750,
2016
Palavra-chave:
Genética;
Marcador molecular
Áreas do conhecimento:
Ciências Biológicas; Genética; Genética Animal
resumo ...
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SALIK, LUCY MILA GARCIA;
DIAS, FERNANDO MAIA SILVA;
Eduardo Carneiro dos Santos;
Mirna Martins Casagrande;
Mielke, Olaf Hermann Hendrik
Áreas do conhecimento:
Ciências Biológicas; Taxonomia dos Grupos Recentes; Sistematica Bionomia e Biodiversidade
resumo ...
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SALIK, LUCY MILA GARCIA;
DIAS, FERNANDO MAIA SILVA;
Eduardo Carneiro dos Santos;
Mirna Martins Casagrande;
Mielke, Olaf Hermann Hendrik
Áreas do conhecimento:
Ciências Biológicas; Taxonomia dos Grupos Recentes; Sistematica Bionomia e Biodiversidade
resumo ...
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Anna Paula Brandt;
Gustavo Jabor Gozii;
Amanda Rocio Pires;
MARTINEZ, GLAUCIA REGINA;
André Vinicius Canuto;
Aurea Echevarria;
Attilio Di Pietro;
Silvia Maria Suter Correia Cadena
Palavra-chave:
mesoionic compounds;
sidnona;
bioenergética;
HepG2
resumo ...
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VANDRESEN, CAMILA CHEVONICA;
Alan Guilherme Gonçalves;
MURAKAMI, FABIO SEIGI;
DUCATTI, DIOGO;
Miguel Noseda;
DUARTE, MARIA EUGÊNIA;
BARREIRA, SANDRA MARA WORANOVICZ
Palavra-chave:
Phytopathogenic fungus;
Cationic porphyrins;
photodynamic inactivation
Áreas do conhecimento:
Ciências Biológicas; Biotecnologia
resumo ...
Photodynamic inactivation (PDI) is an efficient approach for the elimination of a series of microorganisms; however, PDI involving phytopathogenic filamentous fungi is scarce in the literature. In the present study, we have demonstrated the photoinactivating properties of five cationic meso-(1-methyl-4-pyridinio)porphyrins on conidia of the phytopathogen Colletotrichum graminicola. For this purpose, photophysical properties (photostability and 1O2 singlet production) of the porphyrins under study were first evaluated. PDI assays were then performed with a fluence of 30, 60, 90 and 120 J cm−2 and varying the porphyrin concentration from 1 to 25 μmol L−1. Considering the lowest concentration that enabled the best photoinactivation, with the respective lowest effective irradiation time, the meso-(1-methyl-4-pyridinio)porphyrins herein studied could be ranked as follows: triple-charged 4 (1 μmol L−1 with a fluence of 30 J cm−2) > double-charged-trans2 (1 μmol L−1 with 60 J cm−2) > tetra-charged 5 (15 μmol L−1 with 90 J cm−2) > mono-charged 1 (25 μmol L−1 with 120 J cm−2). Double-charged-cis-porphyrin 3 inactivated C. graminicola conidia in the absence of light. Evaluation of the porphyrin binding to the conidia and fluorescence microscopic analysis were also performed, which were in agreement with the PDI results. In conclusion, the cationic porphyrins herein studied were considered efficient photosensitizers to inactivate C. graminicola conidia. The amount and position of positive charges are related to the compounds’ amphiphilicity and therefore to their photodynamic activity.
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VANDRESEN, CAMILA CHEVONICA;
GONÇALVES, ALAN GUILHERME;
MURAKAMI, FABIO SEIGI;
DUCATTI, DIOGO;
NOSEDA, MIGUEL;
DUARTE, MARIA EUGÊNIA;
BARREIRA, SANDRA M. W.
Áreas do conhecimento:
Ciências Biológicas; Microbiologia Aplicada
resumo ...
Photodynamic inactivation (PDI) is an efficient approach for the elimination of a series of microorganisms; however, PDI involving phytopathogenic filamentous fungi is scarce in the literature. In the present study, we have demonstrated the photoinactivating properties of five cationic meso-(1-methyl-4-pyridinio)porphyrins on conidia of the phytopathogen Colletotrichum graminicola. For this purpose, photophysical properties (photostability and 1O2 singlet production) of the porphyrins under study were first evaluated. PDI assays were then performed with a fluence of 30, 60, 90 and 120 J cm−2 and varying the porphyrin concentration from 1 to 25 μmol L−1. Considering the lowest concentration that enabled the best photoinactivation, with the respective lowest effective irradiation time, the meso-(1-methyl-4-pyridinio)porphyrins herein studied could be ranked as follows: triple-charged 4 (1 μmol L−1 with a fluence of 30 J cm−2) > double-charged-trans2 (1 μmol L−1 with 60 J cm−2) > tetra-charged 5 (15 μmol L−1 with 90 J cm−2) > mono-charged 1 (25 μmol L−1 with 120 J cm−2). Double-charged-cis-porphyrin 3 inactivated C. graminicola conidia in the absence of light. Evaluation of the porphyrin binding to the conidia and fluorescence microscopic analysis were also performed, which were in agreement with the PDI results. In conclusion, the cationic porphyrins herein studied were considered efficient photosensitizers to inactivate C. graminicola conidia. The amount and position of positive charges are related to the compounds’ amphiphilicity and therefore to their photodynamic activity.
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