Publicações - ciências da saúde
|
Carlos Alberto Cioce Sampaio;
Liliane Cristine Schlemer Alcântara;
Paulo Henrique Freire Vieira
Palavra-chave:
Bem Viver;
modos de vida;
pandemia;
Ecossocioeconomias
Áreas do conhecimento:
Outros;
Ciências Sociais Aplicadas; Planejamento Urbano e Regional; Planejamento e Sua Gestão Para o Desenvolvimento Local Sustentável;
Ciências da Saúde; Saúde Coletiva; Saúde Pública
resumo ...
(en)
Unexpectedly the new Covid-19’s Pandemic has joined to the multiple interdependent syndromes which configure the accelerated worsening of the global socio-ecological crisis. This suggests the necessity to drastically review the lifestyle in practically all latitudes of the world. The uncertainties generated new civilizing designs almost half a century after the Stockholm Conference. The predictable impacts on the dominant regulation logic of economic and political-institutional systems represent a decisive vector that points in this direction. From this new and disturbing profile of the global crisis, the objective is to analyze the potential contained in the “post-development ecocentric” Good Living’s approach to take a renewed position in the most recent ecopolitical debate - now from the perspective of new lines of reflection that emerged with the outbreak of the Covid-19’s Pandemic. It uses an essay based on a descriptive stage with a literature review and critical theoretical analysis established on the interface and the post-development proposal of Good Living itself overall using the human-scale development thesis of Manfred Max-Neef and the eco-socioeconomics thesis by Karl William Kapp and Ignacy Sachs. The intention is to create a new line of academic reflection on the cognitive and ethical-political limits of the hegemonic neoliberal ideological thought in face of the increasingly disturbing signs of almost irreversible impairment of the System-Earth.
(pt)
De forma inesperada, a nova pandemia do Covid-19 veio se somar às múltiplas síndromes interdependentes que configuram o agravamento acelerado da crise socioecológica global. Uma de suas características mais marcantes tem a ver com o fato de estar contribuindo para sinalizar a necessidade de revisões mais ou menos drásticas de modos de vida sancionados em praticamente todas as latitudes. Ao que tudo indica, as incertezas assim geradas abrem espaço para novos desenhos civilizatórios quase meio século após a realização da Conferência de Estocolmo. Os impactos previsíveis nas lógicas dominantes de regulação dos sistemas econômicos e político-institucionais representam um vetor decisivo que aponta nesta direção. Levando em conta este novo e inquietante perfil da crise global, objetiva-se analisar o potencial contido no enfoque “pós-desenvolvimento-ecocêntrico” do Bem Viver, tendo em vista uma tomada de posição renovada no debate ecopolítico mais recente – agora da perspectiva das novas linhas de reflexão que surgiram com a irrupção da pandemia do Covid-19. Explora-se o potencial criativo contido nesta controvertida noção à luz das contribuições seminais de Manfred Max-Neef sobre desenvolvimento à escala humana, e de Karl William Kapp e Ignacy Sachs sobre ecossocioeconomias. A intenção é balizar, de forma ensaísta, a elaboração de uma nova linha de reflexão acadêmica sobre os limites cognitivos e ético-políticos do pensamento neoliberal hegemônico, frente aos indícios cada vez mais inquietantes de comprometimento mais ou menos irreversível do metabolismo do Sistema-Terra.
|
|
GOULART ROSA, REGIS;
DE SOUZA, EMANUEL MALTEMPI;
DE OLIVEIRA, JAQUELINE CARVALHO;
GRADIA, DANIELA FIORI;
BRANDALIZE, ANA PAULA CARNEIRO;
KUCHARSKI, GABRIELA ALMEIDA;
PEDROTTI, FERNANDO;
Cruz, C.R.;
KYAW, MOE H.;
CASTILLO, GRACIELA DEL CARMEN MORALES;
SRIVASTAVA, AMIT;
SPINARDI, JULIA;
MCLAUGHLIN, JOHN M.;
ALLEN, KRISTEN E.;
MANFIO, JOSÉLIA;
DE ARAUJO, CINTIA LAURA PEREIRA;
COHEN, MÍRIAN;
ROBINSON, CAROLINE CABRAL;
SGANZERLA, DANIEL;
FERREIRA, DIOGO
Palavra-chave:
COVID-19
Áreas do conhecimento:
Ciências da Saúde; Farmacologia; Transmissão Neuromuscular
resumo ...
Introduction Real-world data on COVID-19 vaccine effectiveness are needed to validate evidence from randomized clinical trials. Accordingly, this study aims to evaluate, in a real-world setting in Brazil, the effectiveness of Pfizer-BioNTech BNT162b2 against symptomatic COVID-19 and COVID-19-related complications across diverse populations. Materials and methods A test-negative case-control study with follow-up of cases is currently being conducted in Toledo, a city in southern Brazil, following a mass COVID-19 vaccination campaign with BNT162b2. The study is being conducted among patients aged 12 years or older seeking care in the public health system with acute respiratory symptoms and tested for SARS-CoV-2 on reverse transcription polymerase chain reaction (RT-PCR). Cases are RT-PCR positive and controls RT-PCR negative. Test-positive cases are prospectively followed through structured telephone interviews performed at 15 days post-enrollment, and at 1, 3, 6, 9 and 12 months. Baseline demographic, clinical, and vaccination data are being collected by means of structured interviews and medical registry records reviews at the time of enrollment. All RT-PCR-positive samples are screened for mutations to identify SARS-CoV-2 variants. Ethics and dissemination The study protocol has been approved by the research ethics committee of all participant sites. Study findings will be disseminated through peer-reviewed publications and conference presentations. Trail registration Clinicatrials.gov: NCT05052307.
|
|
GOULART ROSA, REGIS;
DE SOUZA, EMANUEL MALTEMPI;
DE OLIVEIRA, JAQUELINE CARVALHO;
Daniela Fiori Gradia;
BRANDALIZE, ANA PAULA CARNEIRO;
KUCHARSKI, GABRIELA ALMEIDA;
PEDROTTI, FERNANDO;
RODRIGUES, CRISTINA DE OLIVEIRA;
KYAW, MOE H.;
CASTILLO, GRACIELA DEL CARMEN MORALES;
SRIVASTAVA, AMIT;
SPINARDI, JULIA;
MCLAUGHLIN, JOHN M.;
ALLEN, KRISTEN E.;
MANFIO, JOSÉLIA;
DE ARAUJO, CINTIA LAURA PEREIRA;
COHEN, MÍRIAN;
ROBINSON, CAROLINE CABRAL;
SGANZERLA, DANIEL;
FERREIRA, DIOGO
Palavra-chave:
COVID-19
resumo ...
Introduction Real-world data on COVID-19 vaccine effectiveness are needed to validate evidence from randomized clinical trials. Accordingly, this study aims to evaluate, in a real-world setting in Brazil, the effectiveness of Pfizer-BioNTech BNT162b2 against symptomatic COVID-19 and COVID-19-related complications across diverse populations. Materials and methods A test-negative case-control study with follow-up of cases is currently being conducted in Toledo, a city in southern Brazil, following a mass COVID-19 vaccination campaign with BNT162b2. The study is being conducted among patients aged 12 years or older seeking care in the public health system with acute respiratory symptoms and tested for SARS-CoV-2 on reverse transcription polymerase chain reaction (RT-PCR). Cases are RT-PCR positive and controls RT-PCR negative. Test-positive cases are prospectively followed through structured telephone interviews performed at 15 days post-enrollment, and at 1, 3, 6, 9 and 12 months. Baseline demographic, clinical, and vaccination data are being collected by means of structured interviews and medical registry records reviews at the time of enrollment. All RT-PCR-positive samples are screened for mutations to identify SARS-CoV-2 variants. Ethics and dissemination The study protocol has been approved by the research ethics committee of all participant sites. Study findings will be disseminated through peer-reviewed publications and conference presentations. Trail registration Clinicatrials.gov: NCT05052307.
|
|
RONCONI, CRISTIANA SOARES;
ROSSETTO, JULIA DUTRA;
ISSAHO, DAYANE C.;
EJZENBAUM, FABIO;
HOPKER, LUISA MOREIRA;
SOLÉ, DIRCEU;
CHONG-NETO, HERBERTO J.;
Ana Tereza Ramos Moreira;
TABUSE, MARCIA KEIKO;
SANTOS, MYRNA S.
resumo ...
ABSTRACT Allergic conjunctivitis is an increasingly frequent condition with a higher prevalence...
|
|
Ana Luiza Gomes-Domingos;
Helen Hermana Miranda Hermsdorff;
Larissa Loures Mendes;
Fernando Luiz Pereira de Oliveira;
Anderson de Oliveira;
Adriano Marçal Pimenta;
Josefina Bressan
Palavra-chave:
Built environment;
Food Environment;
Geographic Information Systems;
Overweight;
Social Environment
Áreas do conhecimento:
Ciências da Saúde; Análise Nutricional de População;
Ciências da Saúde; Enfermagem; Epidemiologia;
Ciências da Saúde; Saúde Coletiva
resumo ...
Abstract A cross-sectional study enrolled participants from the CUME project (n = 289) who lived...
|
|
Alisson Henrique Marinho;
Gislaine Cristina‐Souza;
Pâmela Souza Santos;
Ana Carla Santos‐Mariano;
Rodacki, A;
Fernando Roberto de Oliveira;
Romulo Bertuzzi;
Adriano Eduardo Lima e Silva
Palavra-chave:
Endurance;
performance
resumo ...
The current study investigated the effect of caffeine on the breathing pattern during a high-intensity whole-body exercise. Using a randomized, crossover, counterbalanced, and double-blind design, twelve healthy men ingested either 5 mg.kg−1 of caffeine or cellulose (placebo) one hour before performing a high-intensity whole-body exercise (i.e., work rate corresponding to 80% of the difference between the gas exchange threshold and maximal oxygen uptake) until the limit of tolerance. Ventilatory and metabolic responses were recorded throughout the trial and at task failure. Caffeine ingestion increased time to task failure in relation to the placebo (368.1 ± 49.6 s vs. 328.5 ± 56.6 s, p = 0.005). Caffeine also increased tidal volume and inspiratory time throughout the exercise (p < 0.05). Compared to task failure with placebo, task failure with caffeine intake was marked by higher (p < 0.05) minute ventilation (134.8 ± 16.4 vs. 147.6 ± 18.2 L.min−1), the ventilatory equivalent of oxygen consumption (37.8 ± 4.2 vs. 41.7 ± 5.5 units), and respiratory exchange ratio (1.12 ± 0.10 vs. 1.19 ± 0.11 units). In conclusion, ingestion of caffeine alters the breathing pattern by increasing tidal volume and lengthening the inspiratory phase of the respiratory cycle. These findings suggest that caffeine affects the ventilatory system, which may account, in part, for its ergogenic effects during high-intensity whole-body exercises.
|
|
Zina Bencheikh;
Wahid Refes;
Patricia Manuit Brito;
Maritana Mela;
Paloma Kachel Gusso-Choueri;
Rodrigo B Choueri;
C A Oliveira Ribeiro
Palavra-chave:
Poluição Marinha;
Qualidade de Agua;
Saúde de Peixes;
histopatologia;
biomarcadores
Áreas do conhecimento:
Ciências Biológicas; Ecologia Aplicada; Ecotoxicologia;
Ciências Biológicas; Zoologia; Zoologia Aplicada; Conservação das Espécies Animais;
Ciências da Saúde; Saúde Coletiva; Saúde Pública
resumo ...
Chronic exposure to multiple pollutants affects aquatic organisms, even at low concentrations, and can impair fishery activities along marine coastlines. The bioavailability of toxic metals and the presence of metals and polycyclic aromatic hydrocarbons (PAHs) in both water and sediment can explain the worst-case scenario of fish health and fishery production decline along the Algeria coastline. The hepatosomatic index (HIS), gonadosomatic index (GSI), and condition factor (K) in the studied species from the Algiers, Bou Ismail, and Zemmouri bays are the first indicators of the poor environmental health along the studied region. These findings could be explained by the bioavailability of Zn, Cu, Cr, Mn, Hg, and Ni and the detection of PAHs in the water and sediment of these bays. Additionally, histopathological damage in the liver is described in sardine (Sardina pilchardus), anchovy (Engraulis encrasicolus), and sardinelle (Sardinella aurita) highlights the current study in the investigation of the risk of exposure to biota or human populations. The occurrence of permanent lesions in the livers of fish impairs organ function and increases the incidence of diseases affecting the fish community. Furthermore, the factor analysis with principal component analysis (FA/PCA) dataset explains the physiological disturbances described in all studied species. These findings revealed that Zemmouri bay is the most affected by chemicals, suggesting that S. pilchardus is the most sensitive species. Finally, the results showed that the bioavailability of chemicals present in the studied bays confirms poor water quality, which can explain the decrease in fishery production along the Algerian Coastline.
|
|
ANDRESSA FLORES SANTOS;
SCHIEFER, ELBERTH M.;
Monica Surek;
Cleverson Antônio F Martins;
Paulo Roberto Worfel;
Guilherme Lanzi Sassaki;
Lauro Meira Souza;
Wesley Maurício de Souza;
Wesley Maurício de Souza
Palavra-chave:
ILEX PARAGUARIENS;
Yerba mate;
Gastroprotection;
Phenolics;
Antimicrobial activity;
antioxidant
Áreas do conhecimento:
Ciências da Saúde; Farmácia; Pharmacognosy;
Ciências da Saúde; Farmácia; Pharmacology
resumo ...
(en)
This study aimed to quantify the total phenolic and flavonoid contents in the aqueous extract of Ilex paraguariensis (EIP) and investigate its antioxidant, antimicrobial, antiulcerogenic, and antidepressant properties with concomitant verification of its effects on relevant biochemical parameters using in vivo models. EIP has in its composition 236.28 ± 11.83 mg GAE/g of total phenolics and 44.07 ± 5.56 mg QE/g of total flavonoids, corroborating its antioxidant activity. Antimicrobial assays against gram-positive (Staphylococcus aureus and Enterococcus faecalis) and gram-negative bacteria (Escherichia coli e Pseudomonas aeruginosa) showed a promising activity of EIP. The EIP administered at 500 and 1000 mg/kg doses prevented the development of gastric ulcers induced in rats following immobilization at 4 °C, however, in the ethanol-induced ulcers no significant effects were observed up to a dose of 1000 mg/kg. Gastric secretion and total acidity index in pylorus-ligated rats were reduced after treatment with EIP, and the pH did not change significantly compared to the control in the tested model. Administration of EIP to mice (250, 500, and 1000 mg/kg) significantly altered the barbiturate-induced sleep time and results of the tail suspension and forced swim test. Repeated doses of EIP did not significantly alter the evaluated biochemical markers (blood glucose, urea, creatinine, triglycerides, and total cholesterol). The results indicate that EIP may relieve gastrointestinal disorders by reducing acid secretion and decreasing immobility time in mice, suggesting an antidepressant effect. Notably, administration of multiple doses of EIP was considered preliminarily safe.
(es)
El presente trabajo tuvo como objetivo cuantificar los niveles de fenoles y flavonoides a partir del extracto acuoso de Ilex paraguariensis (EIP) e investigar sus propiedades antioxidantes, antimicrobianas, antiulcerogénicas y antidepressivas, pero también para analizar sus efectos bioquímicos através de modelos in vivo. EIP es compuesto por 236,28 ± 11,83 mg GAE/g de fenoles totales y 44,07 ± 5,56 mg QE/g de flavonoides totales, lo que justifica su efecto antioxidante. Estos componentes presentan propriedades antimicrobianas contra las bacterias gram positivas (Staphylococcus aureus y Enterococcus faecalis) y gram negativas (Escherichia coli y Pseudomonas aeruginosa). La administración de EIP (500 y 1000 mg/kg) evitó el desarrollo de úlceras gástricas inducidas en los ratones después de la inmovilización a 4°C, mientras que, no se observaron efectos significativos hasta la dosis de 1000 mg/kg de etanol. La secreción gástrica y el índice de acidez total en los ratones con píloro ligado se redujeron considerablemente después del tratamiento con EIP y el pH no cambió en comparación con el modelo control. La administración de EIP en ratones (250, 500 y 1000 mg/kg) alteró significativamente el tiempo de sueño inducido por barbitúricos, y los resultados de la suspensión de la cola y la prueba de nado forzado. Además, las dosis repetidas de EIP no alterarón los marcadores bioquímicos, a saber, la glucemia, urea, creatinina, triglicéridos y colesterol total. Con los resultados de este trabajo indican que EIP puede aliviar las alteraciones gastrointestinales, reduciendo la secreción gástrica y disminuyendo el tiempo de inmovilidad en ratones, por esta razón puede ser un efecto antidepresivo. Del mismo modo, la administración de múltiples dosis de EIP se consideró segura.
(pt)
Este estudo teve como objetivo quantificar os teores fenólicos e flavonóides totais no extrato aquoso de Ilex paraguariensis (EIP) e investigar suas propriedades antioxidantes, antimicrobianas, antiulcerogênicas e antidepressivas com verificação concomitante de seus efeitos em parâmetros bioquímicos relevantes por meio de modelos in vivo. O EIP possui em sua composição 236,28 ± 11,83 mg GAE/g de fenólicos totais e 44,07 ± 5,56 mg QE/g de flavonóides totais corroborando com sua atividade antioxidante. Ensaios antimicrobianos contra bactérias gram-positivas (Staphylococcus aureus e Enterococcus faecalis) e gram-negativas (Escherichia coli e Pseudomonas aeruginosa) mostraram uma promissora atividade do EIP. O EIP administrado em doses de 500 e 1000 mg/kg evitou o desenvolvimento de úlceras gástricas induzidas em ratos após imobilização a 4 °C, contudo, nas úlceras induzidas por etanol não foram observados efeitos significativos até dose de 1000 mg/kg. A secreção gástrica e o índice de acidez total em ratos com ligadura no piloro foram reduzidos após o tratamento com EIP e o pH não alterou significativamente em comparação com o controle no modelo testado. A administração de EIP em camundongos (250, 500 e 1000 mg/kg) alterou significativamente o tempo de sono induzido por barbitúricos e os resultados da suspensão da cauda e do teste de natação forçada. Doses repetidas de EIP não alteraram significativamente os marcadores bioquímicos avaliados (glicemia, uréia, creatinina, triglicerídeos e colesterol total). Os resultados indicam que EIP pode aliviar distúrbios gastrointestinais, reduzindo a secreção gástrica e diminuindo o tempo de imobilidade em camundongos, sugerindo um efeito antidepressivo. Notavelmente, a administração de doses múltiplas de EIP foi considerada preliminarmente segura.
|
|
Beatriz Mario Martin;
Allan Arnold Evans;
Denise Siqueira de Carvalho;
EMIKO SHIMAKURA, SILVIA
Palavra-chave:
Dengue;
severe dengue;
Pregnancy;
maternal mortality
Áreas do conhecimento:
Ciências da Saúde; Saúde Coletiva; Epidemiologia
resumo ...
The increasing number of dengue cases worldwide implies a greater exposure of at-risk groups, such as pregnant women. DENV infection during pregnancy has been increasingly associated with unfavorable outcomes, but the evolution of the disease and its clinical outcomes remain unclear. The objective of this study was to characterize dengue cases in reproductive aged women by comparing the development of the disease in pregnant and non-pregnant women. A population based retrospective cohort study that used data reported in the Brazilian Mandatory Notifiable Diseases Information System from 2016 to 2019 in Paraná, Brazil. We compared sociodemographic, clinical, and laboratory variables between pregnant and non-pregnant women. Hospitalization and disease severity classification (Dengue, Dengue with warning signs, Severe Dengue) were considered outcome variables. The two groups had differences in the year of notification, age distribution, and region of residence. Laboratory investigation was more frequent among pregnant women, and DENV-2 prevailed in both groups. The risks of hospitalization and development of Severe Dengue were higher in pregnant women. There were no deaths observed among pregnant women. This study identified pregnancy as a risk factor for an increase in the severity of DENV infection. It reinforces the importance of identifying early signs of complication, close monitoring, and adequate treatment for pregnant women.
|
|
DA SILVA, LETÍCIA POPHAL;
Natalia Boneti Moreira;
Renata Zacharias Grando;
Paulo César Barauce Bento;
Rodacki, A
Palavra-chave:
Octogenarians;
longevidade;
Atividade física;
Envelhecimento
resumo ...
|
