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Publicações - ciências biológicas

Potentiation of Paclitaxel-Induced Pain Syndrome in Mice by Angiotensin I Converting Enzyme Inhibition and Involvement of Kinins BRUSCO, INDIARA; CABRINI, D; GOMEZ, MARCUS VINÍCIUS; Juliano Ferreira; Oliveira, Sara Marchesan; Silva, Cássia Regina; Trevisan, Gabriela; DE CAMPOS VELHO GEWEHR, CAMILA; RIGO, FLÁVIA KARINE; LA ROCCA TAMIOZZO, LIDIA; Rossato, Mateus Fortes; TONELLO, RAQUEL; Dalmolin, Gerusa Duarte MOLECULAR NEUROBIOLOGY, p. 1 2016 DOI Palavra-chave: Chemotherapy; bradykinin; Mechanical allodynia; Neuropathy; Nociceptive behaviour Áreas do conhecimento: Ciências Biológicas; Bioquímica dos Microorganismos; Enzimologia resumo ... Paclitaxel is a chemotherapeutic agent used to treat solid tumours. However, it causes an acute and neuropathic pain syndrome that limits its use. Among the mechanisms involved in neuropathic pain caused by paclitaxel is activation of kinin receptors. Angiotensin converting enzyme (ACE) inhibitors can enhance kinin receptor signalling. The goal of this study was to evaluate the role of kinins on paclitaxel-associated acute pain syndromes (P-APS) and the effect of ACE inhibition on P-APS and paclitaxel-associated chronic peripheral neuropathy (P-CPN) in mice. Herein, we show that paclitaxel caused mechanical allodynia and spontaneous nociceptive behaviour that was reduced by antagonists of kinin receptors B1 (DALBk and SSR240612) and B2 (Hoe140 and FR173657). Moreover, enalapril (an ACE inhibitor) enhanced the mechanical allodynia induced by a low dose of paclitaxel. Likewise, paclitaxel injection inhibited ACE activity and increased the expressions of B1 and B2 receptors and bradykinin-related peptides levels in peripheral tissue. Together, our data support the involvement of kinin receptors in the P-APS and suggest kinin receptor antagonists to treat this syndrome. Because hypertension is the most frequent comorbidity affecting cancer patients, treatment of hypertension with ACE inhibitors in patients undergoing paclitaxel chemotherapy should be reviewed, since this could enhance the P-APS and P-CPN.
Production of pectinases by solid-state fermentation in a pilot-scale packed-bed bioreactor Luana de Oliveira Pitol; Alessandra Biz; Edgar Mallmann; KRIEGER, NADIA; MITCHELL, DAVID ALEXANDER Chemical Engineering Journal (1996), v. 283, p. 1009-1018, 2016 DOI Palavra-chave: biorreator; Fermentação em estado sólido; Biorrefinaria; pectinases Áreas do conhecimento: Engenharias; Engenharia Química; Processos Industriais de Engenharia Química; Processos Bioquímicos; Ciências Biológicas; Microbiologia; Microbiologia Aplicada; Microbiologia Industrial e de Fermentação resumo ...
Production of pectinases by solid-state fermentation of a mixture of citrus waste and sugarcane bagasse in a pilot-scale packed-bed bioreactor Alessandra Biz; Anelize Terezinha Jung Finkler; Luana de Oliveira Pitol; Bruna Schweitzer Medina; KRIEGER, NADIA; MITCHELL, DAVID ALEXANDER Biochemical Engineering Journal, v. 111, p. 54-62, 2016 DOI Palavra-chave: pectinases; solid-state fermentation; packed-bed bioreactor Áreas do conhecimento: Engenharias; Engenharia Química; Processos Industriais de Engenharia Química; Processos Bioquímicos; Ciências Biológicas; Microbiologia; Microbiologia Aplicada; Microbiologia Industrial e de Fermentação resumo ...
Production of pectinases by solid-state fermentation of a mixture of citrus waste and sugarcane bagasse in a pilot-scale packed-bed bioreactor Alessandra Biz; Anelize Terezinha Jung Finkler; Luana de Oliveira Pitol; Bruna Schweitzer Medina; KRIEGER, NADIA; MITCHELL, DAVID ALEXANDER Biochemical Engineering Journal, v. 111, p. 54-62, 2016 DOI Palavra-chave: pectinases; solid-state fermentation; bioreactor Áreas do conhecimento: Ciências Biológicas; Microbiologia Aplicada; Microbiologia Industrial e de Fermentação; Ciências Biológicas; Bioquímica; Enzimologia resumo ...
Protective Effect of the Sulfated Agaran Isolated from the Red Seaweed Laurencia aldingensis Against Toxic Effects of the Venom of the Snake, Lachesis muta DA SILVA, ANA CLÁUDIA RODRIGUES; FERREIRA, LUCIANA GARCIA; DUARTE, MARIA EUGÊNIA RABELLO; FUJII, MUTUE TOYOTA; SANCHEZ, ELADIO FLORES; Miguel Noseda; FULY, ANDRÉ LOPES MARINE BIOTECHNOLOGY, v. 18, n. 6, p. 619-629, 2016 DOI Palavra-chave: Sulfated agaran; polysaccharide; Lachesis muta; Protective effect; Red Seaweed; Snake venom Áreas do conhecimento: Ciências Biológicas; Biotecnologia resumo ... Snakebite is a serious occupational hazard affecting mainly rural populations of tropical and subtropical developing countries. Lachesis muta (Bushmaster) bites are extremely serious but are rarely reported in the literature. Bushmaster envenomings are characterized by intense local pain, edema, neurotoxicity, hypotension, local hemorrhage, and dramatic systemic alterations. Antivenom treatment has regularly been used for more than a century; however, it fails to neutralize local tissue damage and hemorrhage, leading to morbidity or disabilities in victims. Thus, the production and clinical use of antivenom must be improved. The present work characterizes, for the first time, a sulfated polysaccharide from the red seaweed, Laurencia aldingensis, including its neutralizing effect on some toxic activities of L. muta venom. Chemical and spectroscopic analyses showed that L. aldingensis produces sulfated agarans with the A-units partially C-2 sulfated or 6-O-methoxylated presetting the B-units in the cyclized (3,6-anhydro-α-L-galactose) or in the non-cyclized form (α-L-galactose). The latter is significantly substituted by sulfate groups on C-6. In vitro and in vivo assays showed that this sulfated agaran inhibited hemolysis, coagulation, proteolysis, edema, and hemorrhage of L. muta venom. Neutralization of hemorrhagic activity was also observed when the agaran was administered by different routes and after or before the venom injection. Furthermore, the agaran blocked the edema caused by a phospholipase A2 isolated from the L. muta venom. Experimental evidence therefore indicates that the sulfated agaran of L. aldingensis has potential to aid antivenom therapy of accidents caused by L. muta venom and may help to develop more effective antivenom treatments of snake bites in general.
Proteomic and morphological changes produced by subinhibitory concentration of isoniazid in CAMPANERUT-SÁ, PAULA AZ; Emanuel Maltempi de Souza; CARDOSO, ROSILENE F; GHIRALDI-LOPES, LUCIANA D; MENEGUELLO, JEAN E; Adriana Fiorini Rosado; EVARISTO, GEISA PC; SIQUEIRA, VERA LD; SCODRO, REGIANE BL; PATUSSI, ELIANA V; Donatti, Lucélia Future Microbiology (Print), v. 11, n. 9, p. 1123-1132, 2016 DOI Palavra-chave: proteomic; Mycobacterium tuberculosis Áreas do conhecimento: Ciências Biológicas; Bioquímica dos Microorganismos; Enzimologia; Ciências Biológicas; Microbiologia; Biologia e Fisiologia dos Microorganismos; Virologia; Ciências Biológicas; Bioquímica; Bioquímica resumo ... Aim: To study the proteomic and morphological changes in Mycobacterium tuberculosis H37Rv exposed to subinhibitory concentration of isoniazid (INH). Materials & methods: The bacillus was exposed to...
Proteomic and morphological changes produced by subinhibitory concentration of isoniazid in Mycobacterium tuberculosis CAMPANERUT-SÁ, PAULA AZ; Emanuel Maltempi de Souza; CARDOSO, ROSILENE F; GHIRALDI-LOPES, LUCIANA D; MENEGUELLO, JEAN E; FIORINI, ADRIANA; EVARISTO, GEISA PC; SIQUEIRA, VERA LD; SCODRO, REGIANE BL; PATUSSI, ELIANA V; Donatti, Lucélia Future Microbiology (Print), v. 11, n. 9, p. 1123-1132, 2016 DOI Palavra-chave: proteome; Mycobacterium tuberculosis. Áreas do conhecimento: Ciências Biológicas; Microbiologia; Biologia e Fisiologia dos Microorganismos; Bacteriologia; Ciências Biológicas; Bioquímica; Bioquímica dos Microorganismos resumo ... Aim: To study the proteomic and morphological changes in Mycobacterium tuberculosis H37Rv exposed to subinhibitory concentration of isoniazid (INH). Materials & methods: The bacillus was exposed to...
Quantitative genotoxicity assays for analysis of medicinal plants: A systematic review Graziela Sponchiado; Mônica Lucia Adam; Caroline DADALT SILVA; Bruna da Silva Soley; Cristina de Mello-Sampayo; CABRINI, D; Cassyano Januário Correr; OTUKI, M Journal of Ethnopharmacology, v. 178, p. 289-296, 2016 DOI Palavra-chave: Genotoxicity; assays; medicinal plants Áreas do conhecimento: Ciências Biológicas; Bioquímica dos Microorganismos; Enzimologia; Ciências Biológicas; Farmacologia; Toxicologia; Toxicologia Ambiental resumo ...
Race-Related Differences in Left Ventricular Structural and Functional Remodeling in Response to Increased Afterload AMOR, MIGUEL; MATSUSHITA, KUNIHIRO; MOSLEY, THOMAS; LAM, CAROLYN S.P.; BORLAUG, BARRY A.; SOLOMON, SCOTT D.; SHAH, AMIL M.; HEGDE, SHEILA; GONÇALVES, ALEXANDRA; CLAGGETT, BRIAN; CHENG, SUSAN; NADRUZ, WILSON; KITZMAN, DALANE W.; KONETY, SUMA H. JACC-Heart Failure, v. Nov, p. S2213-1779(16)3 2016 DOI Palavra-chave: Hypertension; Arterial Elastance; Cardiac Remodeling; Race Áreas do conhecimento: Ciências da Saúde; Medicina; Clínica Médica; Cardiologia; Ciências Biológicas; Fisiologia; Fisiologia de Órgãos e Sistemas; Fisiologia Cardiovascular resumo ...
Range extension of the Atlantic Forest Hocicudo, Oxymycterus dasytrichus (Schinz, 1821), to the state of Santa Catarina, southern Brazil PEÇANHA, WILLIAN THOMAZ; GONÇALVES, GISLENE LOPES; ALTHOFF, SÉRGIO LUIZ; FREITAS, THALES RENATO OCHOTORENA DE; Iris Hass CHECK LIST, JOURNAL OF SPECIES LIST AND DISTRIBUTION, v. 12, n. 1, p. 1847 2016 DOI Palavra-chave: Akodontini; Rodentia; Floresta ombrófila densa Áreas do conhecimento: Ciências Biológicas; Genética; Genética da Conservação; Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes; Ciências Biológicas; Genética; Genética Molecular Animal resumo ... Six individuals of Oxymycterus dasytrichus (Schinz, 1821) were found on the coast of Paraná and Santa Catarina (in the Atlantic Forest), expanding the known geographical distribution of the species ca. 280 km southward. The specimens represent the first record of the species for the state of Santa Catarina, and new localities to the region of southern Paraná. The identification of the species relied mainly on interspecies comparative assessment of genetic distance based on DNA sequences data from the mitochondrial cytochrome-b gene and geographic distribution of taxa across biomes, particularly in the Atlantic Forest. Our findings highlight the role of protected areas, particularly the Guaraqueçaba Environmental Protection Area, to preserve small mammals.

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