Publicações - ciências biológicas
|
GOMES, LUCAS R.P.;
GONZÁLEZ, ALEJANDRO RESTREPO;
Cláudio J B Carvalho;
COURI, MÁRCIA S.;
FOGAÇA, JOÃO M.;
ROPER, JAMES J.
Palavra-chave:
myiasis;
Neotropical region;
Parasitism;
parakeet;
woodcreeper
Áreas do conhecimento:
Ciências Biológicas; Bioquímica dos Microorganismos; Enzimologia;
Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes;
Ciências Biológicas; Parasitologia
resumo ...
|
|
GOMES, LUCAS ROBERTO PEREIRA;
Cláudio J B Carvalho
Palavra-chave:
biodiversity;
identification key;
morphology;
New records
Áreas do conhecimento:
Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes;
Ciências Biológicas; Morfologia
resumo ...
ABSTRACT Calythea Schnabl & Dziedzicki has 15 known species distributed worldwide, including...
|
|
MARIO CUPELLO;
Cibele Stramare Ribeiro-Costa;
Fernando Vaz de Melo
Palavra-chave:
Taxonomy;
morphology;
Scarabaeidae
Áreas do conhecimento:
Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes
resumo ...
Abstract. The distribution of the iridescent dung beetle Bolbites onitoides can be divided, based on dorsal colouration, into a blue western-half and a red
|
|
Regiane Stafim da Cunha;
Carolina Amaral Bueno Azevedo;
Carlos Alexandre Falconi;
Fernanda Fogaça Ruiz;
Sophie Liabeuf;
Marcela Sorelli Carneiro-Ramos;
Andréa Emília Marques Stinghen
Palavra-chave:
Uremic Toxins;
Drugs;
Membrane Transporters;
Albumin
Áreas do conhecimento:
Ciências da Saúde; Medicina; Clínica Médica; Nefrologia;
Ciências Biológicas; Bioquímica; Bioquímica
resumo ...
Uremic toxins are a heterogeneous group of molecules that accumulate in the body due to the progression of chronic kidney disease (CKD). These toxins are associated with kidney dysfunction and the development of comorbidities in patients with CKD, being only partially eliminated by dialysis therapies. Importantly, drugs used in clinical treatments may affect the levels of uremic toxins, their tissue disposition, and even their elimination through the interaction of both with proteins such as albumin and cell membrane transporters. In this context, protein-bound uremic toxins (PBUTs) are highlighted for their high affinity for albumin, the most abundant serum protein with multiple binding sites and an ability to interact with drugs. Membrane transporters mediate the cellular influx and efflux of various uremic toxins, which may also compete with drugs as substrates, and both may alter transporter activity or expression. Therefore, this review explores the interaction mechanisms between uremic toxins and albumin, as well as membrane transporters, considering their potential relationship with drugs used in clinical practice.
|
|
MULLER, CRISTIANE SATO MARA;
GINER, IGOR SAMESIMA;
ZAMBALDE, ERIKA PEREIRA;
CARVALHO, TAMYRES MINGORANCE;
RIBEIRO, ENILZE MARIA DE SOUZA FONSECA;
CARVALHO DE OLIVEIRA, JAQUELINE;
MATHIAS, CAROLINA;
Daniela Fiori Gradia
Palavra-chave:
lncRNA;
NORAD;
Pumilio proteins;
RALGAPB;
Breast cancer;
Biomarkers
Áreas do conhecimento:
Ciências Biológicas; Genética Humana e Médica
resumo ...
Introduction: Long non-coding RNAs (LncRNA) represent a heterogeneous family of RNAs that have emerged as regulators of various biological processes through their association with proteins in ribonucleoproteins complexes. The dynamic of these interactions can affect cell metabolism, including cancer development. Annually, breast cancer causes thousands of deaths worldwide, and searching for new biomarkers is pivotal for better diagnosis and treatment. Methods: Based on in silico prediction analysis, we focus on LncRNAs that have binding sites for PUMILIO, an RBP family involved in post-transcriptional regulation and associated with cancer progression. We compared the expression levels of these LncRNAs in breast cancer and non-tumor samples from the TCGA database. We analyzed the impact of overall and disease-free survival associated with the expression of the LncRNAs and co-expressed genes and targets of PUMILIO proteins. Results: Our results found NORAD as the most relevant LncRNA with a PUMILIO binding site in breast cancer, differently expressed between Luminal A and Basal subtypes. Additionally, NORAD was co-expressed in a Basal-like subtype (0.55) with the RALGAPB gene, a target gene of PUMILIO related to chromosome stability during cell division. Conclusion: These data suggest that this molecular axis may provide insights for developing novel therapeutic strategies for breast cancer.
|
|
SCHÖBEL, CHRISTIAN;
Gervásio Silva Carvalho;
Andressa Paladini;
TEIXEIRA, RENATO AUGUSTO
Palavra-chave:
Paramere;
Angles;
Tegmina;
color polymorphism;
Taxon
Áreas do conhecimento:
Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes;
Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes; Sistemática
resumo ...
|
|
Pinto, Ângelo P.;
Ângelo Parise Pinto;
Marcus Vinícius Oliveira De Almeida;
EHLERT, JULIANA
Palavra-chave:
Anisoptera;
Libelluloidea;
Corduliinae;
new synonymies;
Species delimitation
Áreas do conhecimento:
Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes;
Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes
resumo ...
ABSTRACT Three Atlantic Forest endemic species of emerald dragonflies of the genus Navicordulia...
|
|
ZAMBALDE, ERIKA PEREIRA;
ADAMOSKI, DOUGLAS;
Daniela Fiori Gradia;
RABINOVICH, IRIS;
RODRIGUES, ANA CAROLINA;
IVAN, CRISTINA;
RIBEIRO, ENILZE M. S. F.;
CALIN, GEORGE ADRIAN;
CARVALHO DE OLIVEIRA, JAQUELINE
Palavra-chave:
T-UCRs;
Breast cancer;
lncRNA
Áreas do conhecimento:
Ciências Biológicas; Genética Humana e Médica
resumo ...
Ultraconserved regions (UCRs) are 481 genome segments, with length longer than 200 bp, that are 100% conserved among humans, mice, and rats. The majority of UCRs are transcriptionally active (T-UCRs) as many of them produce non-coding RNAs. In a previous study, we evaluated the expression level of T-UCRs in breast cancer (BC) patients and found that 63% of transcripts correlated with some clinical and/or molecular parameter of BC. In this study, we delved into the expression levels of 12 T-UCRs and correlated them with clinicopathological parameters, immunohistochemical markers, and overall survival in two breast cancer cohorts: TCGA and Brazilian patients. We found that uc.268 is more expressed in TCGA patients under 40 years of age, associated with progesterone receptor (PR) and estrogen receptor (ER), and its high expression is found in luminal A. Lower uc.84 and uc.376 were respectively observed in metastatic and stage IV tumors associated with good prognostic in luminal B. Moreover, uc.84 was only related to the HER2+, while uc.376 was related to ER+ and PR+, and HER2+. A panel composed of uc.147, uc.271, and uc.427 distinguished luminal A from triple negative patients with an AUC of 0.9531 (sensitivity 92.19% and specificity 86.76%). These results highlight the potential role of T-UCRs in BC and provide insights into the potential application of T-UCRs as biomarkers.
|
|
JOERIN-LUQUE, IRIEL A.;
Augusto, Danillo G.;
CALONGA-SOLÍS, VERÓNICA;
DE ALMEIDA, RODRIGO COUTINHO;
LOPES, CLAUDEMIRA VIEIRA GUSMÃO;
Maria Luiza Petzl-Erler;
BELTRAME, MARCIA HOLSBACH
Palavra-chave:
population genetics;
ancestry markers;
admixture;
uniparental markers
Áreas do conhecimento:
Ciências Biológicas; Genética Humana e Médica
resumo ...
The Brazilian population is a product of asymmetric admixture among European men and Amerindian and African women. However, Brazilian subcontinental ancestry is scarcely documented, especially regarding its African roots. Here, we aimed to unveil the uniparental continental and subcontinental contributions from distinct Brazilian regions, including South (n = 43), Southeast (n = 71), the poorly genetically characterized Central-Western region (n = 323), and a subset of unique Brazilian Amerindians (n = 24), in the context of their genome-wide ancestral contributions. The overwhelming majority of European Y haplogroups (85%) contrast sharply with the predominant African and Amerindian mtDNA haplogroups (73.2%) in admixed populations, whereas in Amerindians, non-Native haplogroups could only be detected through the paternal line. Our in-depth investigation of uniparental markers showed signals of an Andean and Central-Brazilian Amerindian maternal contribution to Southeastern and Central-Western Brazil (83.1 ± 2.1% and 56.9 ± 0.2%, respectively), the last having the highest paternal Amerindian ancestry yet described for an admixed Brazilian region (9.7%) and contrasting with higher Southern-Brazilian Amerindian contribution to Southern Brazil (59.6 ± 1%). Unlike the higher African Bantu contribution previously reported for the South and Southeast, a relevant Western African non-Bantu contribution was detected in those regions (85.7 ± 5% and 71.8 ± 10.8% respectively). In contrast, a higher Bantu contribution was described for the first time in the Central-West (64.8 ± 1.3% maternal and 86.9 ± 9.6% paternal). We observed sex-biased signatures consistent with the historically recorded Brazilian colonization and added new insights in the subcontinental maternal ancestry of Brazilians from regions never studied at this level.
|
|
Regiane Stafim da Cunha;
Paulo Cézar Gregório;
Rayana A. Pereira;
Giane Favretto;
Celia Regina Cavichiolo Franco;
JJenifer Pendiuk Gonçalves;
Marina M. Azevedo;
PECOITS-FILHO, Roberto;
Andréa Emília Marques Stinghen
Palavra-chave:
chronic kidney disease;
Endothelial dysfunction;
Uremic Toxins;
CREB/ATF1 Pathway
Áreas do conhecimento:
Ciências da Saúde; Medicina; Nefrologia Experimental;
Ciências da Saúde; Medicina; Clínica Médica; Nefrologia;
Ciências Biológicas; Bioquímica; Bioquímica
resumo ...
|
