Publicações - ciências biológicas
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DE MARCHI, MICHELI;
MOGGIO, ERICK LAURENT;
DA LUZ, JESSICA ZABLOCKI;
Patricia Manuit Brito;
Silvana Sandri;
Sandra Helena Poliselli Farsky;
Stelee M P Biscaia;
Francisco Filipack Neto;
C A Oliveira Ribeiro
Palavra-chave:
BDE - 209;
Melanoma murino;
Prognóstico do cancer;
Toxicologia celular;
Saúde Pública
Áreas do conhecimento:
Ciências da Saúde; Saúde Pública;
Ciências Biológicas; Ecologia; Ecologia Aplicada
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HASEYAMA, KIRSTERN LICA FOLLMANN;
BOIARSKI, MARIA CAROLINA ROMAGNA;
Elaine Della Giustina Soares;
NIHEI, SILVIO S.;
Cláudio J B Carvalho
Palavra-chave:
Atlantic Forest;
identification key;
Neotropical;
Phylogeny;
Taxonomy
Áreas do conhecimento:
Ciências Biológicas; Bioquímica dos Microorganismos; Enzimologia;
Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes;
Ciências Biológicas; Zoologia; Biogeografia
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Estevan Luiz da Silveira;
José Marcelo Rocha Aranha;
Márcia Santos de Menezes;
André Martins Vaz dos Santos
Palavra-chave:
spatial distribution;
Age and growth;
growth parameters;
Reproductive Biology;
Gonadal development
Áreas do conhecimento:
Ciências Biológicas; Ecologia; Ecologia Aplicada;
CIENCIAS_AGRARIAS; Recursos Pesqueiros e Engenharia de Pesca; Recursos Pesqueiros de Águas Interiores;
Ciências Biológicas; Zoologia; Zoologia Aplicada; Conservação das Espécies Animais
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SULZBACH DENARDIN, MAIARA;
PFÖHLER, CLAUDIA;
WORM, MARGITTA;
VAN BEEK, NINA;
GOEBELER, MATTHIAS;
SÁRDY, MIKLÓS;
IBRAHIM, SALEH;
BUSCH, HAUKE;
SCHMIDT, ENNO;
HUNDT, JENNIFER ELISABETH;
Petzl-Erler, Maria Luiza;
BUMILLER-BINI HOCH, VALÉRIA;
Angelica Beate Winter Boldt;
SALVIANO-SILVA, AMANDA;
LOBO-ALVES, SARA CRISTINA;
ADELMAN CIPOLLA, GABRIEL;
MALHEIROS, DANIELLE;
Augusto, Danillo G.;
WITTIG, MICHAEL;
FRANKE, ANDRE
Palavra-chave:
HDAC;
modificações das histonas;
HAT;
epigenética;
pênfigo foliáceo;
PHF21A
Áreas do conhecimento:
Ciências Biológicas; Genética Humana e Médica;
Ciências Biológicas; Genética; Epigenética
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Pemphigus foliaceus (PF) is an autoimmune skin blistering disease characterized by antidesmoglein-1 IgG production, with an endemic form (EPF) in Brazil. Genetic and epigenetic factors have been associated with EPF, but its etiology is still not fully understood. To evaluate the genetic association of histone (de)acetylation-related genes with EPF susceptibility, we evaluated 785 polymorphisms from 144 genes, for 227 EPF patients and 194 controls. Carriers of HDAC4_rs4852054*A were more susceptible (OR = 1.79, p = 0.0038), whereas those with GSE1_rs13339618*A (OR = 0.57, p = 0.0011) and homozygotes for PHF21A_rs4756055*A (OR = 0.39, p = 0.0006) were less susceptible to EPF. These variants were not associated with sporadic PF (SPF) in German samples of 75 SPF patients and 150 controls, possibly reflecting differences in SPF and EPF pathophysiology. We further evaluated the expression of histone (de)acetylation-related genes in CD4+ T lymphocytes, using RNAseq. In these cells, we found a higher expression of KAT2B, PHF20, and ZEB2 and lower expression of KAT14 and JAD1 in patients with active EPF without treatment compared to controls from endemic regions. The encoded proteins cause epigenetic modifications related to immune cell differentiation and cell death, possibly affecting the immune response in patients with PF.
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Daniele Costa Batalha;
André Martins Vaz dos Santos;
Estevan Luiz da Silveira;
Antônio Olinto Ávila da Silva;
Lilian Dena dos Santos
Palavra-chave:
plastic pollution;
danger;
Diet;
Micropogonias furnieri;
Brazil
Áreas do conhecimento:
Ciências Exatas e da Terra; Oceanografia Biológica; Interação entre os Organismos Marinhos e os Parâmetros Ambientais;
CIENCIAS_AGRARIAS; Recursos Pesqueiros e Engenharia de Pesca; Recursos Pesqueiros Marinhos;
Ciências Biológicas; Zoologia; Zoologia Aplicada; Conservação das Espécies Animais
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DA SILVA, ANA PAULA;
de Castilhos Ghisi, Nédia;
POQUIOMA HERNÁNDEZ, HILDA VANESSA;
COMELLI, CAMILA LUIZA;
GUILLÉN PORTUGAL, MIGUEL ANGEL;
MOREIRA DELAVY, FERNANDA;
DE SOUZA, TUGSTENIO LIMA;
DE OLIVEIRA, ELTON CELTON;
C A Oliveira Ribeiro;
Helena Cristina da Silva de Assis
Palavra-chave:
meta-analise;
mechanismo antioxidante;
Peixes
Áreas do conhecimento:
Ciências Biológicas; Ecologia Aplicada; Ecotoxicologia
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STAKOWIAN, NICOLE;
Carolina Arruda de Oliveira Freire
Palavra-chave:
osmoregulation;
Bivalvia;
Cyrtopleura
Áreas do conhecimento:
Ciências Biológicas; Fisiologia Comparada; Fisiologia Comparativa da Osmorregulação
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ABSTRACT. Cyrtopleura costata is a pholadid bivalve that inhabits tidal flats inside burrows c. 40 cm deep, and its visceral mass outgrows its shell signif
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ZABLOCKI DA LUZ, J.;
LIMA DE SOUZA, T.;
DE ALMEIDA ROQUE, A.;
OPUSKEVITCH, I.;
ALVES DA SILVA FERREIRA, F. C.;
MELA PRODOCIMO, M.;
C A Oliveira Ribeiro;
Filipak Neto, Francisco
Palavra-chave:
Toxicologia celular;
hepatocitos;
Oreochromis niloticus
Áreas do conhecimento:
Ciências Biológicas; Ecologia; Ecologia Aplicada;
Ciências Biológicas; Ecologia; Ecologia Aplicada; Ecotoxicologia
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Risk assessment studies on aquatic pollution, a threat to water quality and aquatic biota, often rely on animal capture and experimentation. However, ethical concerns surrounding animal use have prompted the development and use of alternative methods. This study investigates the viability of primary hepatocyte cultures from Oreochromis niloticus as an in vitro tool for environmental contaminant screening, focusing on cadmium as a pollutant model. Isolated hepatocytes were cultured on plates using a mixture of supplemented L15/F12 media. Freezing conditions were tested for cell stock preservation. The cultured hepatocytes were exposed to 0.5, 5, and 50 µM of cadmium to assess cell viability, reactive oxygen and nitrogen species, and antioxidant molecules. Results demonstrated a concentration and time-dependent decrease in cell viability upon cadmium exposure. Cadmium exposure also induced an imbalance in the antioxidant defense system, leading to increased reactive oxygen species levels and lipid peroxidation. These findings validate the cadmium toxicity to primary hepatocytes and confirm the applicability of commonly used biomarkers in animal-based ecotoxicology and risk assessment studies. The replication of these biomarkers in primary hepatocyte cultures provides an ethical alternative to reduce animal testing in ecotoxicology. Lastly, the study highlights the potential of primary hepatocyte cultures as an in vitro tool for evaluating the toxicity of environmental contaminants and supports the integration of this tool in future environmental risk assessment studies, promoting sustainable water resource management while reducing reliance on animal experimentation.
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Laura Regina Caramori;
Adriano Brilhante Kury;
Ângelo Parise Pinto
Palavra-chave:
Araucaria Forest;
biodiversity;
historiography;
Marumbi massif;
species checklist;
Wallacean shortfall
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ABSTRACT The knowledge of the diversity and distribution of Opiliones in Brazil can be...
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ANDRADE, BIANCA O.;
BENCKE, GLAYSON ARIEL;
BENEDUZI, ANELISE;
SILVA, JORGE BERNARDO;
BLOCHTEIN, BETINA;
BOLDRINI, ILSI IOB;
BOLL, PITER KEHOMA;
BORDIN, JUÇARA;
SILVEIRA, ROSA MARA BORGES DA;
MARTINS, MÁRCIO BORGES;
BOSENBECKER, CAMILA;
DROSE, WILLIAM;
BRACCINI, JOÃO;
AGUIAR, CASSIANA ALVES DE;
AIRES, ELISA TEIXEIRA;
ALVARES, DIEGO JANISCH;
BARBIERI, ROSA LIA;
Cláudio J B Carvalho;
BARTZ, MARIE;
BECKER, FERNANDO GERTUM
Palavra-chave:
animal diversity;
biogeographic survey;
Brazilian Pampa;
conservation;
open ecosystem
Áreas do conhecimento:
Ciências Biológicas; Bioquímica dos Microorganismos; Enzimologia;
Ciências Biológicas; Botânica; Fisiologia Vegetal;
Ciências Biológicas; Zoologia; Biogeografia
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