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Publicações - ciências biológicas

Nanostructured Cellulose-Gellan-Xyloglucan-Lysozyme Dressing Seeded with Mesenchymal Stem Cells for Deep Second-Degree Burn Treatment COSTA DE OLIVEIRA SOUZA, CAROLINA MARIA; DE SOUZA, CLAYTON FERNANDES; MOGHARBEL, BASSAM FELIPE; IRIODA, ANA CAROLINA; Franco, Celia R.C.; SIERAKOWSKI, MARIA RITA; ATHAYDE TEIXEIRA DE CARVALHO, KATHERINE International Journal of Nanomedicine, v. Volume 16, p. 833-850, 2021 DOI Palavra-chave: Nanostructured Cellulose?Gellan?Xyloglucan?Lysozym; Mesenchymal Stem Cells resumo ... Nanostructured Cellulose–Gellan–Xyloglucan–Lysozyme Dressing Seeded with Mesenchymal Stem Cells for Deep Second-Degree Burn Treatment
Natural parasitism in fruit fly (Diptera: Tephritidae) and interaction with wild hosts surrounding apple orchards adjacent to Atlantic Forest fragments in Paraná State, Brazil Lino Bittencourt Monteiro; Guilhermne Nishimura; Rodrigo Shuler Monteiro BRAZILIAN JOURNAL OF BIOLOGY, v. 83, p. e250505 2021 DOI Palavra-chave: Mata Atlântica; parasitóide; Macieira; hospedeiros Áreas do conhecimento: CIENCIAS_AGRARIAS; Tecnologia de Alimentos; Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes; Ciências Biológicas; Ecologia; Ecologia de Ecossistemas resumo ... Abstract The South American fruit fly, Anastrepha fraterculus (Wiedemann, 1830) (Diptera:...
NEAT1 and MALAT1 are highly expressed in saliva and nasopharyngeal swab sample of COVID¿19 patients RODRIGUES, ANA CAROLINA; Daniela Fiori Gradia; OLIVEIRA, JAQUELINE CARVALHO; ADAMOSKI, DOUGLAS; GENELHOULD, GUSTAVO; ZHEN, FELIPE; YAMAGUTO, GUILHERME EIJI; SOUZA, PATRÍCIA SAVIO DE ARAUJO; NOGUEIRA, MERI BORDIGNON; RABONI, SONIA MARA; BONATTO, ANA CLAUDIA Molecular Oral Microbiology, v. 1, p. 1 2021 DOI Palavra-chave: COVID-19; Saliva; nasopharyngeal swab; lncRNAs; NEAT1; MALAT1 Áreas do conhecimento: Ciências Biológicas; Genética Humana e Médica resumo ...
Neotropical Stomopogon (Diptera, Muscidae): new species, redescriptions and key to species FOGAÇA, JOÃO M.; GOMES, LUCAS R. P.; COURI, MÁRCIA S.; RODRÍGUEZ-FERNANDEZ, JAIME I.; Cláudio J B Carvalho ZOOTAXA, v. 4903, n. 3, p. 301-330, 2021 DOI Palavra-chave: Ultrastructural morphology; Taxonomy; Revision Áreas do conhecimento: Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes; Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes resumo ... (en) Stomopogon Malloch (Diptera, Muscidae) is a Neotropical genus recorded from Argentina, Bolivia, Brazil, Chile and Peru. In this contribution, the genus is revised, and three new species are described, one from Bolivia (Murillo, La Paz), one from Brazil (Palmas, Paraná) and one from Peru (Wayqecha, Cuzco). The descriptions include color images, illustrations and ultrastructural morphology of the terminalia of the adult. We provide an identification key to the species of Stomopogon and an updated map with species’ distributions. Stomopogon acuta (Malloch, 1934) is proposed as a new junior synonym of S. inculta Stein, 1911.
Neutrophil Extracellular Traps: A Perspective of Neuroinflammation and Complement Activation in Alzheimer?s Disease Gabriela Canalli Kretzschmar; Valéria Bumiller Bini; Miguel Ângelo Gasparetto Filho; Yohan Ricci Zonta; Kaio Shu Tsyr Yu; Ricardo Lehtonen Rodrigues de Souza; Luciane Alarcão Dias-Melicio; Angelica Beate Winter Boldt FRONTIERS IN MOLECULAR BIOSCIENCES, v. 8, p. 630869 2021 DOI Palavra-chave: NET; NETose; doença de Alzheimer; complemento; CR1; neutrófilos Áreas do conhecimento: Ciências Biológicas; Bioquímica dos Microorganismos; Enzimologia; Ciências Biológicas; Imunologia; Imunologia Celular; Imunofarmacologia resumo ... Complement system (CS) components are associated with Alzheimer’s disease (AD), the commonest cause of dementia in the world. Neutrophils can be attracted to amyloid-β plaques by several pro-inflammatory factors, including the complement anaphylatoxin C5a. They may release neutrophil extracellular traps (NETs), which are chromatin nets associated with myeloperoxidase, elastase, and other enzymes. Some CS molecules, such as C5a, C1q, and CR1, are associated with increased neutrophil recruitment and NETs release. However, the relationship between CS molecules and NETs in AD is poorly understood. In this work, we detected higher NET concentrations in plasma and serum of Brazilian AD patients, than in elderly controls (medians = 2.78 [2.07–6.19] vs. 2.23 [0.33–4.14] ng/mL, p = 0.0005). We discussed these results within the context of our former findings on complement and AD and the context of the literature on complement and NET release, suggesting both as possible therapeutic targets to prevent the progress of the disease.
New traps for the capture of Aedes aegypti (Linnaeus) and Aedes albopictus (Skuse) (Diptera: Culicidae) eggs and adults ROSSI DA SILVA, KARINA; Mário Antonio NavarroSilva; João Antonio Cyrino Zequi; RIBEIRO DA SILVA, WILLIAM; SILVA, BIANCA PIRACCINI; ARCOS, ADRIANO NOBRE; DA SILVA FERREIRA, FRANCISCO AUGUSTO; SOARES-DA-SILVA, JOELMA; PONTES, GRAFE OLIVEIRA; ROQUE, ROSEMARY APARECIDA; TADEI, WANDERLI PEDRO PLoS Neglected Tropical Diseases, v. 15, n. 4, p. e0008813-16, 2021 DOI Palavra-chave: Diptera; Culicidae; Aedes aegypti; Ecologia de Vetores; Dengue Áreas do conhecimento: Ciências Biológicas; Bioquímica dos Microorganismos; Enzimologia; Ciências Biológicas; Zoologia; Fisiologia dos Grupos Recentes; Ciências Biológicas; Zoologia; Comportamento Animal resumo ... Author summary Aedes aegypti and Aedes albopictus are species of mosquitoes responsible for the transmission of several arboviruses that cause infections worldwide. However, there are still no effective and safe vaccines or medications to prevent or treat arboviruses transmitted by these vectors, except for yellow fever. Moreover, current methodologies for monitoring and controlling A. aegypti and A. albopictus are not fully effective, as evidenced by the increasing cases of the arbovirus transmitted by these mosquitoes or have incompatible costs with the socioeconomic conditions of a large number of people. Thus, the traps tested in this study can be used as more effective and economical tools for monitoring A. aegypti and A. albopictus, since they are made with low cost material and they showed high efficiency in the capture of eggs, evidenced by the high values of ovitraps positive index and eggs density index, besides that one of the models captured Aedes spp. adults in both regions where they were tested. Therefore, the traps have potential for reducing Aedes spp. eggs and adults in the environment and sensibility for determining the local infestation index, which can be reconciled with official government strategies for more accurate vector monitoring actions.
Novel HLA-A, HLA-B, and HLA-DRB1 alleles identified in Brazilian individuals Jessica Tavares; Natalia A.Petry,; José Samuel da Silva; BICALHO, M. G.; Patrícia Savio de Araujo-Souza HLA, v. n/a, n. n/a, p. 2059-2302, 2021 Home page Áreas do conhecimento: Ciências Biológicas; Genética; Genética Humana e Médica; Imunogenética resumo ...
Novel lncRNAs Co-Expression Networks Identifies LINC00504 with Oncogenic Role in Luminal A Breast Cancer Cells MATHIAS, CAROLINA; Daniela Fiori Gradia; DE OLIVEIRA, JAQUELINE C.; GROENEVELD, CLARICE S.; TREFFLICH, SHEYLA; ZAMBALDE, ERIKA P.; LIMA, RUBENS S.; URBAN, CÍCERO A.; PRADO, KARIN B.; RIBEIRO, ENILZE M. S. F.; CASTRO, MAURO A. A. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 5, p. 2420 2021 DOI Palavra-chave: lncRNAs; Breast cancer; co-expression; LINC00504; Luminal A Áreas do conhecimento: Ciências Biológicas; Genética Humana e Médica; Ciências Biológicas; Genética; Bioinformática resumo ... Long non-coding RNAs (lncRNAs) are functional transcripts with more than 200 nucleotides. These molecules exhibit great regulatory capacity and may act at different levels of gene expression regulation. Despite this regulatory versatility, the biology of these molecules is still poorly understood. Computational approaches are being increasingly used to elucidate biological mechanisms in which these lncRNAs may be involved. Co-expression networks can serve as great allies in elucidating the possible regulatory contexts in which these molecules are involved. Herein, we propose the use of the pipeline deposited in the RTN package to build lncRNAs co-expression networks using TCGA breast cancer (BC) cohort data. Worldwide, BC is the most common cancer in women and has great molecular heterogeneity. We identified an enriched co-expression network for the validation of relevant cell processes in the context of BC, including LINC00504. This lncRNA has increased expression in luminal subtype A samples, and is associated with prognosis in basal-like subtype. Silencing this lncRNA in luminal A cell lines resulted in decreased cell viability and colony formation. These results highlight the relevance of the proposed method for the identification of lncRNAs in specific biological contexts.
Obesity-like metabolic effects of high-carbohydrate or high-fat diets consumption in metabolic and renal functions Isabela Coelho; Luiz Cláudio Fernandes; Danielle C. T. Pequito; Ricardo Fernandez Perez ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, v. 127, p. 1-11, 2021 DOI Home page Palavra-chave: Obesity; Mouse; High-Fat Diet; high-carbohydrate diet Áreas do conhecimento: Ciências Biológicas; Fisiologia de Órgãos e Sistemas; Fisiologia da Digestão; Ciências Biológicas; Fisiologia; Fisiologia de Órgãos e Sistemas; Fisiologia Renal resumo ... Present study investigated which diet, high-carbohydrate (HCD) or high-fat (HFD), most effectively induces classical characteristics of obesity in mice. Mice were fed commercial chow (control), an ...
On the novel mechanisms for social memory and the emerging role of neurogenesis Paula Santana Lunardi; MANSK, LARA M.Z.; JAIMES, LAURA F.; PEREIRA, GRACE S. BRAIN RESEARCH BULLETIN, v. 171, p. 56-66, 2021 DOI Home page Palavra-chave: social memory; Neurogenesis; Hippocampus resumo ...

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