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Publicações - ciências biológicas

Flower morphology is correlated with distribution and phylogeny in Bertolonia (Melastomataceae), an herbaceous genus endemic to the Atlantic Forest BACCI, LUCAS F.; AMORIM, ANDRÉ M.; MICHELANGELI, FABIAN A.; Renato Goldenberg MOLECULAR PHYLOGENETICS AND EVOLUTION, v. 149, p. 106844 2020 DOI Áreas do conhecimento: Ciências Biológicas; Taxonomia Vegetal; Taxonomia de Fanerógamos resumo ...
Forty years of the description of Brown spider venom phospholipases-D. Luiza Helena Gremski; Silvio Sanches Veiga; Hanna Camara Justa; Thais Pereira da Silva; Polli, N.L.C.; Antunes, B. C.; João Minozzo; MARTINS WILLE, ANA CAROLINA; Andrea Senff Ribeiro; Arni, Raghuvir Krishnaswamy Toxins, v. 12, n. 164, p. 1 2020 DOI Palavra-chave: Aranha marrom; fosfolipase-D; Veneno Áreas do conhecimento: Ciências Biológicas; Bioquímica dos Microorganismos; Enzimologia; Ciências Biológicas; Bioquímica; Biologia Molecular resumo ... Spiders of the genus Loxosceles, popularly known as Brown spiders, are considered a serious public health issue, especially in regions of hot or temperate climates, such as parts of North and South America. Although the venoms of these arachnids are complex in molecular composition, often containing proteins with distinct biochemical characteristics, the literature has primarily described a family of toxins, the Phospholipases-D (PLDs), which are highly conserved in all Loxosceles species. PLDs trigger most of the major clinical symptoms of loxoscelism i.e., dermonecrosis, thrombocytopenia, hemolysis, and acute renal failure. The key role played by PLDs in the symptomatology of loxoscelism was first described 40 years ago, when researches purified a hemolytic toxin that cleaved sphingomyelin and generated choline, and was referred to as a Sphingomyelinase-D, which was subsequently changed to Phospholipase-D when it was demonstrated that the enzyme also cleaved other cellular phospholipids. In this review, we present the information gleaned over the last 40 years about PLDs from Loxosceles venoms especially with regard to the production and characterization of recombinant isoforms. The history of obtaining these toxins is discussed, as well as their molecular organization and mechanisms of interaction with their substrates. We will address cellular biology aspects of these toxins and how they can be used in the development of drugs to address inflammatory processes and loxoscelism. Present and future aspects of loxoscelism diagnosis will be discussed, as well as their biotechnological applications and actions expected for the future in this field.
Fruticuline A, a chemically-defined diterpene, exerts antineoplastic effects in vitro and in vivo by multiple mechanisms CORSO, CLAUDIA RITA; Stefanello, Maria Élida Alves; VERHOEVEN, ARTHUR J.; OUDE ELFERINK, RONALD P. J.; Acco, Alexandra; STIPP, MARIA CAROLINA; RADULSKI, DÉBORA RASEC; MARIOTT, MARIHÁ; DA SILVA, LUISA MOTA; DE SOUZA RAMOS, EDNEIA AMANCIO; KLASSEN, GISELI; Queiroz Telles, José Ederaldo; OLIVEIRA, CRISTHIAN SANTOS Scientific Reports, v. 10, n. 1, p. 16477 2020 DOI Palavra-chave: Lamiaceae; Salvia lachnostachys; Fruticulina A; ATIVIDADE ANTITUMORAL Áreas do conhecimento: Ciências Exatas e da Terra; Química; Química Orgânica; Química dos Produtos Naturais; Ciências Biológicas; Farmacologia; Farmacologia Geral resumo ... Natural products have been recognized as important bioactive compounds on the basis of their wide biological properties. Here we investigated the antitumor effect and molecular mechanisms of the diterpene Fruticuline A (fruti) from Salvia lachnostachys, in human cancer cell lineages and Solid Ehrlich Carcinoma in mice. Fruti reduced MCF-7 and HepG2 proliferation by the reduction of Cyclin D1 levels and decreased NF-κB gene levels in both cell types. Furthermore, fruti also induced apoptosis in HepG2 cells, reduced Bcl-2 gene expression and induced necroptosis by increasing Ripk in MCF-7 cells. In mice, fruti prevented tumor development and reduced Cyclin D1, Bcl-2 and Rela gene levels, and reduced the p-NF-κB/NF-κB ratio in tumor tissue. Furthermore, fruti induced necrosis and apoptosis, increased N-acetyl-β-D-glucosaminidase and TNF-α levels and reduced IL-10 and Vegf levels in tumor tissue. Collectively, fruti exerts antitumor effects through the inhibition of the NF-κB pathway, reducing Cyclin D1 and Bcl-2 levels. In vitro the apoptosis and necroptosis pathways are involved in the cellular death, whereas in vivo, cells undergo necrosis by increased tumor inflammation and reduction of angiogenesis. Thus, fruticuline A acts in tumor cells by multiple mechanisms and represents a promising molecule for drug development in cancer treatment.
Fruticuline A, a chemically-defined diterpene, exerts antineoplastic effects in vitro and in vivo by multiple mechanisms CORSO, CLAUDIA RITA; STEFANELLO, MARIA ÉLIDA ALVES; VERHOEVEN, ARTHUR J.; OUDE ELFERINK, RONALD P. J.; ACCO, ALEXANDRA; STIPP, MARIA CAROLINA; RADULSKI, DÉBORA RASEC; MARIOTT, MARIHÁ; DA SILVA, LUISA MOTA; DE SOUZA RAMOS, EDNEIA AMANCIO; Giseli Klassen; Queiroz Telles, José Ederaldo; OLIVEIRA, CRISTHIAN SANTOS Scientific Reports, v. 10, n. 1, p. 16477 2020 DOI Palavra-chave: Câncer de mama; Tumor de Ehrlich; Diterpeno resumo ... Natural products have been recognized as important bioactive compounds on the basis of their wide biological properties. Here we investigated the antitumor effect and molecular mechanisms of the diterpene Fruticuline A (fruti) from Salvia lachnostachys, in human cancer cell lineages and Solid Ehrlich Carcinoma in mice. Fruti reduced MCF-7 and HepG2 proliferation by the reduction of Cyclin D1 levels and decreased NF-κB gene levels in both cell types. Furthermore, fruti also induced apoptosis in HepG2 cells, reduced Bcl-2 gene expression and induced necroptosis by increasing Ripk in MCF-7 cells. In mice, fruti prevented tumor development and reduced Cyclin D1, Bcl-2 and Rela gene levels, and reduced the p-NF-κB/NF-κB ratio in tumor tissue. Furthermore, fruti induced necrosis and apoptosis, increased N-acetyl-β-D-glucosaminidase and TNF-α levels and reduced IL-10 and Vegf levels in tumor tissue. Collectively, fruti exerts antitumor effects through the inhibition of the NF-κB pathway, reducing Cyclin D1 and Bcl-2 levels. In vitro the apoptosis and necroptosis pathways are involved in the cellular death, whereas in vivo, cells undergo necrosis by increased tumor inflammation and reduction of angiogenesis. Thus, fruticuline A acts in tumor cells by multiple mechanisms and represents a promising molecule for drug development in cancer treatment.
Functional traits reveal coastal vegetation assembly patterns in a short edaphic gradient in southern Brazil Cleusa Bona; Robertta Moryel Pellanda; Marcos Bergmann Carlucci; Rebekah de Paula Machado; Daniela Ciccareli FLORA, p. 151661 2020 DOI Palavra-chave: restinga; Características funcionais; Plantas costeiras Áreas do conhecimento: Ciências Biológicas; Bioquímica dos Microorganismos; Enzimologia; Ciências Biológicas; Botânica; ecologia vegetal resumo ...
Genetic investigation on the pathophysiology and clinical symptoms of Hereditary Angioedema Tatielly Kruk; Lucas Marques Fortunato; Caroline Guth de Freitas Batista de Moraes; Herberto José Chong Neto; Liya Regina Mikami; Pereira-Ferrari, Lilian; ROSÁRIO FILHO, NELSON A. RESEARCH, SOCIETY AND DEVELOPMENT, v. 9, n. 9, p. EXX 2020 DOI Palavra-chave: angioedema hereditário Áreas do conhecimento: Ciências Biológicas; Bioquímica dos Microorganismos; Enzimologia resumo ...
Genotoxic, metabolic, and biological responses of Chironomus sancticaroli Strixino & Strixino, 1981 (Diptera: Chironomidae) after exposure to BBP. Gisele dos Santos Morais; Thalita Bastida Vieira; Gustavo Souza Santos; Rafael Garrett Dolatto; Cestari, M.M.; Marco Tadeu Grassi; NAVARRO DA SILVA, MÁRIO ANTÔNIO SCIENCE OF THE TOTAL ENVIRONMENT, v. 715, p. 136937 2020 DOI Palavra-chave: Genotoxicidade; ecogenotoxicidade; ensaio cometa Áreas do conhecimento: Ciências Biológicas; Genética; genotoxicidade resumo ...
Genotoxic, metabolic, and biological responses of Chironomus sancticaroli Strixino & Strixino, 1981 (Diptera: Chironomidae) after exposure to BBP DOS SANTOS MORAIS, GISELE; VIEIRA, THALITA BASTIDA; SANTOS, GUSTAVO SOUZA; DOLATTO, RAFAEL GARRETT; Cestari, M.M.; GRASSI, MARCO TADEU; Mário Antonio NavarroSilva SCIENCE OF THE TOTAL ENVIRONMENT, v. 715, p. 136937 2020 DOI Palavra-chave: Diptera; Chironomidae; Impactos ambientais; fisiologia comparada Áreas do conhecimento: Ciências Biológicas; Bioquímica dos Microorganismos; Enzimologia; Ciências Biológicas; Zoologia; Fisiologia dos Grupos Recentes resumo ...
Genotoxicity detected during cyanobacteria bloom in a water supply reservoir WUNSCHE, L.; Taynah Vicari; CALADO, S.L.M.; WOJCIECHOWSKI, J.; MAGALHÃES, V.F.; ASSIS, H.C.S.; LEME, D.M.; Cestari, M.M. ECOTOXICOLOGY AND ENVIRONMENTAL CONTAMINATION, v. 15, p. 51-60, 2020 DOI Palavra-chave: micronúcleo; citotoxicidade; Genotoxicidade; Allium cepa Áreas do conhecimento: Ciências Biológicas; Genética; Genética Animal; Mutagênese Ambiental; Ciências Biológicas; Genética; genotoxicidade resumo ...
Geographical patterns and current and short-term historical correlates of phylogenetic diversity and endemism for New World primates Luiz Henrique Varzinczak; Thais Bastos Zanata; MOURA, MAURICIO O.; Fernando C. Passos JOURNAL OF BIOGEOGRAPHY, v. 47, n. 4, p. 890-902, 2020 DOI Palavra-chave: areas of endemism; community phylogenetics; endemism; Neotropics; phylogenetic endemism; Platyrrhini resumo ...

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