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Publicações - ciências biológicas

O gênero Adiantum (Pteridaceae) no Estado do Paraná, Brasil Ana Lucia Brozoski; Jefferson Prado; Paulo H. Labiak IHERINGIA SERIE BOTANICA, v. 78, p. e2023021 2023 DOI Palavra-chave: Diversidade; Flora; Mata Atlântica; Samambaias; Taxonomia Áreas do conhecimento: Ciências Biológicas; Botânica; Taxonomia Vegetal; Taxonomia de Criptógamos resumo ...
On making (and turning adaptive to) maladaptive aversive memories in laboratory rodents GAZARINI, L; Cristina Aparecida Jark Stern; Leandro José Bertoglio NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 147, p. 105101 2023 DOI Palavra-chave: Condicionamento; consolidação; Extinção; Generalização; PTSD; psicofarmacologia Áreas do conhecimento: Ciências Biológicas; Farmacologia; Neuropsicofarmacologia resumo ...
One-step selective layer assemble: A versatile approach for the development of a SARS-CoV-2 electrochemical immunosensor MARTINS, GUSTAVO; MARCOLINO-JUNIOR, LUIZ HUMBERTO; BERGAMINI, MARCIO F.; GALESKI, HELENA R.; ANDRADE, GABRIELLE A.; VALENGA, MARCIA G.P.; RAMOS, MARIA K.; ZARBIN, ALDO J.G.; JANEGITZ, BRUNO C.; Marcelo Müller dos Santos; Emanuel Maltempi de Souza ANALYTICA CHIMICA ACTA, v. 1278, p. 341726 2023 DOI Home page Palavra-chave: Biosensing; Electrochemical immunosensors; SARS-CoV-2 detection; One-step-assemble; N-protein Áreas do conhecimento: Ciências Biológicas; Imunologia; Imunologia Aplicada; Imunologia Animal resumo ...
One-step selective layer assemble: A versatile approach for the development of a SARS-CoV-2 electrochemical immunosensor MARTINS, GUSTAVO; MARCOLINO-JUNIOR, LUIZ HUMBERTO; BERGAMINI, MARCIO F.; GALESKI, HELENA R.; ANDRADE, GABRIELLE A.; VALENGA, MARCIA G.P.; RAMOS, MARIA K.; ZARBIN, ALDO J.G.; JANEGITZ, BRUNO C.; Marcelo Muller dos Santos; Emanuel Maltempi de Souza ANALYTICA CHIMICA ACTA, v. 1278, p. 341726 2023 DOI Home page Palavra-chave: Biosensing; Electrochemical immunosensors; SARS-CoV-2 detection; One-step-assemble; N-protein Áreas do conhecimento: Ciências Biológicas; Imunologia; Imunologia Aplicada; Imunologia Animal resumo ...
Paecilins Q and R: Antifungal chromanones produced by the endophytic fungus Pseudofusicoccum stromaticum CMRP4328 IANTAS, JUCELIA; SAVI, DAIANI; Larissa V. Ponomareva; THORSON, JON S.; Jurgen Rohr; Chirlei Glienke; Khaled A. Shaaban PLANTA MEDICA, p. 1-13, 2023 DOI Palavra-chave: Endophytic fungi; atividade antimicrobiana; Pseudofusicoccum stromaticum resumo ...
Paranaguá Estuarine Complex Diatoms: Morphology and Molecular Taxonomy RAMPINELLI, VIVIANE DE FÁTIMA MOURA AGUILLAR; LUDWIG, THELMA ALVIM VEIGA; FERREIRA, PAULA CAROLINA; KAVA, VANESSA; CONCEIÇÃO, DANIELE; SANTOS, BEATRIZ; MARRA, RAQUEL; PASSOS, MATHEUS FELIPE; PETERSEN, RODOLFO; Jóse Viriato Coelho Vargas; GALLI-TERASAWA, LYGIA VITÓRIA; SAVI, DAIANI BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY (ONLINE), v. 66, p. e23210523 2023 DOI Palavra-chave: bioprospection; DNA-barcode; rbcL; Navicula pseudoantonii; Nitzschia inconspicua Áreas do conhecimento: Ciências Biológicas; Biotecnologia; Biotecnologia Ambiental e Recursos Naturais; Bioprospecção resumo ...
PD-1/PD-L1 Inhibitors Response in Triple-Negative Breast Cancer: Can Long Noncoding RNAs Be Associated? MATHIAS, CAROLINA; KOZAK, VANESSA NASCIMENTO; MAGNO, JESSICA MARIA; BAAL, SUELEN CRISTINA SOARES; DOS SANTOS, VICTOR HENRIQUE APOLONIO; RIBEIRO, ENILZE MARIA DE SOUZA FONSECA; Daniela Fiori Gradia; CASTRO, MAURO ANTONIO ALVES; CARVALHO DE OLIVEIRA, JAQUELINE Cancers, v. 15, n. 19, p. 4682 2023 DOI Palavra-chave: HCP5; UCA1; immune response; Immunotherapy; tumor microenvironment Áreas do conhecimento: Ciências Biológicas; Genética Humana e Médica resumo ... As immune checkpoint inhibitors (ICI) emerge as a paradigm-shifting treatment option for patients with advanced or metastatic cancer, there is a growing demand for biomarkers that can distinguish which patients are likely to benefit. In the case of triple-negative breast cancer (TNBC), characterized by a lack of therapeutic targets, pembrolizumab approval for high-risk early-stage disease occurred regardless of PD-L1 status, which keeps the condition in a biomarker limbus. In this review, we highlight the participation of long non-coding RNAs (lncRNAs) in the regulation of the PD-1/PD-L1 pathway, as well as in the definition of prognostic immune-related signatures in many types of tumors, aiming to shed light on molecules that deserve further investigation for a potential role as biomarkers. We also conducted a bioinformatic analysis to investigate lncRNAs already investigated in PD-1/PDL-1 pathways in other cancer types, considering the TNBC molecular context. In this sense, from the generated data, we evidence here two lncRNAs, UCA1 and HCP5, which have not yet been identified in the context of the tumoral immune response in breast cancer. These candidates can be further explored to verify their use as biomarkers for ICI response. In this article, we present an updated review regarding the use of lncRNA as biomarkers of response to ICI, highlighting the versatility of using these molecules.
Phosphodiesterase 4 inhibition after retrieval switches the memory fate favoring extinction instead of reconsolidation MACHADO BATISTA SOHN, JEFERSON; CARDOSO, NATHALIE CARLA; RAYMUNDI, ANA MARIA; PRICKAERTS, JOS; Cristina Aparecida Jark Stern Scientific Reports, v. 13, p. 1 2023 DOI Palavra-chave: BDNF; Condicionamento; Extinção; Fosfodiesterase; psicofarmacologia Áreas do conhecimento: Ciências Biológicas; Farmacologia; Neuropsicofarmacologia resumo ... Phosphodiesterase 4 (PDE4), an enzyme expressed in the dorsal hippocampus (DH), hydrolyzes the cAMP, limiting the PKA-induced CREB phosphorylation (pCREB) and BDNF expression. Depending on the brain region, PKA and pCREB mediate reconsolidation or extinction, whereas BDNF is mainly related to extinction facilitation. The mechanisms underpinning the switch between reconsolidation and extinction are relatively unknown. Here, we tested the hypothesis that PDE4 might control these processes. We showed in Wistar rats submitted to contextual fear conditioning that PDE4 inhibition with roflumilast (ROF) within the DH, after a short retrieval, did not change freezing behavior after one day (TestA1). After 10 days, the ROF-treated group significantly reduced the expression of freezing behavior. This effect depended on retrieval, Test A1 exposure, and reinstated after a remainder foot shock, suggesting an extinction facilitation. The ROF effect depended on PKA after retrieval or, protein synthesis after Test A1. After retrieval, ROF treatment did not change the pCREB/CREB ratio in the DH. It enhanced proBDNF expression without changing pre-proBDNF or mature BDNF in the DH after Test A1. The results suggest that the inhibition of PDE4 in the DH after a short retrieval changes the memory sensibility from reconsolidation to extinction via regulating proBDNF expression.
Photoinactivation of Colletotrichum truncatum, Corynespora cassiicola, Sclerotinia sclerotiorum and Rhizoctonia solani in soybean seeds by cationic porphyrins SAULLE, CAROLINA C.; CLAUS, ALEXANDRE; SALES, LETÍCIA DE A.; Alan Guilherme Gonçalves; Diogo R. B. Ducatti; Miguel Noseda; MAY DE MIO, LOUISE L. PLANT PATHOLOGY (ONLINE), v. 72, n. 1, p. 67-75, 2023 DOI Palavra-chave: Phytopathogenic fungi Áreas do conhecimento: Ciências Biológicas; Bioquímica; Biotecnologia resumo ...
Photosynthesis-related responses of Chlorella sorokiniana (Trebouxiophyceae) to environmentally relevant concentrations of Cu nanoparticles Daniela Mariano Barreto; Alessandra Emanuele Tonietto; Everton Willian ROdrigues da Silva Oliveira; AMARAL, CLARICE DIAS BRITTO; PULGROSSI, RAFAEL CATOIA; POLPO, A.; NÓBREGA, JOAQUIM ARAÚJO; Ana Teresa Lombardi PHYCOLOGIA, v. 62, p. 315-323, 2023 DOI Palavra-chave: nanoparticula metalica Áreas do conhecimento: Ciências Biológicas; ECOTOXICOLOGIA resumo ...

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