Publicações - ciências biológicas


MITCHELL, DAVID ALEXANDER; KRIEGER, NADIA
BIOCHEMICAL ENGINEERING JOURNAL, v. 189, p. 108737 2022 DOI
Palavra-chave: transglycosylation; ping pong bi bi; cinética enzimática
Áreas do conhecimento: Engenharias; Engenharia Química; Processos Industriais de Engenharia Química; Processos Bioquímicos; Ciências Biológicas; Bioquímica; Enzimologia; Cinética Enzimática
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MITCHELL, DAVID ALEXANDER; KRIEGER, NADIA
BIOCHEMICAL ENGINEERING JOURNAL, v. 189, p. 108737 2022 DOI
Palavra-chave: transglicosilação; cinética enzimática; ping pong bi bi
Áreas do conhecimento: Ciências Biológicas; Bioquímica; Bioquímica dos Microorganismos; Biotecnologia; Ciências Biológicas; Bioquímica; cinética enzimática
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Daiane Momo Daneluz; Jeferson M. B. Sohn; Gabriela O Silveira; Mauricio Yonamine; Cristina Aparecida Jark Stern
PSYCHOPHARMACOLOGY, p. 1 2022 DOI
Palavra-chave: Condicionamento; consolidação; Ayahuasca; Reconsolidação; PTSD
Áreas do conhecimento: Ciências Biológicas; Farmacologia; Neuropsicofarmacologia
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To uncover whether psychedelic drugs attenuate fear memory responses would advance the development of better psychedelic-based treatments for posttraumatic stress disorder (PTSD). Ayahuasca (AYA), a psychedelic brew containing indolamine N, N-dimethyltryptamine (DMT) and β-carbolines, facilitates fear extinction and improves neural plasticity. Upon retrieval, fear memory undergoes labilization and reconsolidation; however, the effects of AYA on this memory stabilization phase are unknown. We aimed to investigate the effects of AYA treatment on fear memory reconsolidation. Fear-conditioned Wistar rats received AYA (60, 120, or 240 mg/kg) or H2O orally via gavage o.g. 20 min before, immediately, or 3 h after a short retrieval session. Analysis of AYA through liquid chromatography-tandem mass spectrometry was used to determine the content of DMT and β-carbolines in AYA. AYA impaired fear memory reconsolidation when given 20 min before or 3 h after memory retrieval, with the dose of 60 mg/kg being effective at both moments. This dose of AYA was devoid of anxiolytic effect. Importantly, during retrieval, AYA did not change fear expression. The lack of retrieval abolished the reconsolidation impairing effect of AYA. The effects of AYA treatment 20 min before or 3 h after memory retrieval lasted at least 22 days, suggesting no spontaneous recovery of fear memory. Fear memory impairments induced by AYA treatment, at both moments, do not show reinstatement. Our findings support the view that a low dose of AYA treatment impairs early and late stages of memory reconsolidation instead of facilitating fear extinction.
LEMOS, DÉBORA S.; SOUZA, EMANUEL M.; SILVA, ROSIANE V.; WOWK, PRYSCILLA F.; Maria Luiza Petzl-Erler; ALMEIDA, RODRIGO C.; ADELMAN CIPOLLA, GABRIEL; BOLDT, ANGELICA B.W.; Danielle Malheiros Ferreira; BECKERT, HELEN C.; OLIVEIRA, LUANA C.; BERTI, FERNANDA C.B.; OZAWA, PATRICIA M.M.; SOUZA, INGRID L.M.; ZANATA, SILVIO M.; PANKIEVICZ, VÂNIA C.S.; TULESKI, THALITA R.
BBA Advances, v. 2, p. 100053 2022 DOI
Palavra-chave: Celiac disease; microRNA; lactose intolerance; extracellular vesicle; gluten-free diet
Áreas do conhecimento: Ciências Biológicas; Genética Humana e Médica
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LEMOS, DÉBORA S.; SOUZA, EMANUEL M.; SILVA, ROSIANE V.; WOWK, PRYSCILLA F.; Petzl-Erler, Maria Luiza; ALMEIDA, RODRIGO C.; ADELMAN CIPOLLA, GABRIEL; Angelica Beate Winter Boldt; MALHEIROS, DANIELLE; BECKERT, HELEN C.; OLIVEIRA, LUANA C.; BERTI, FERNANDA C.B.; OZAWA, PATRICIA M.M.; SOUZA, INGRID L.M.; ZANATA, SILVIO M.; PANKIEVICZ, VÂNIA C.S.; TULESKI, THALITA R.
BBA Advances, v. 2, p. 100053 2022 DOI
Palavra-chave: Doença Celíaca; miRNA; microvesículas; Gluten; miR-99b-3p; miR-374b-5p
Áreas do conhecimento: Ciências Biológicas; Genética Humana e Médica
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GERNET, MARCOS DE V.; SIMONE, LUIZ RICARDO L.; Carlos Eduardo Belz; OMURA, GIOVANNA Y.S.; BIRCKOLZ, CARLOS JOÃO; DOMINGOS, FABRICIUS M.C.B.
Zoologia, v. 39, p. 1 2022 DOI Home page
Palavra-chave: moluscos; Sambaqui; Gastropoda
Áreas do conhecimento: Ciências Biológicas; Bioquímica dos Microorganismos; Enzimologia; Ciências Humanas; Arqueologia; Ciências Biológicas; Zoologia; Malacologia
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ABSTRACT Mirinaba cadeadensis Lange de Morretes, 1952 is restricted to the Paraná state, and...
PIECZAK, FERNANDA DE SIQUEIRA; SMIDT, ERIC DE CAMARGO; ENGELS, MATHIAS ERICH; MACHADO, REBEKAH GIESE DE PAULA; Cleusa Bona
FLORA, v. 1, p. 152045 2022 DOI Home page
Palavra-chave: Anatomy; Goodyerinae; micromorfologia da flor; anatomia floral; anatomia nectário
Áreas do conhecimento: Ciências Biológicas; Bioquímica dos Microorganismos; Enzimologia; Ciências Biológicas; Botânica; Morfologia Vegetal; Anatomia Vegetal
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ALVES-ARAÚJO, ANDERSON; TULER, AMÉLIA; AMORIM, ANDRÉ; MOREIRA, ANDRÉ; COSENZA, BRAZ; SOSSAI, BRENNO; SILVA, CHRISTIAN; LOPES, CLAUDIA; MONTEIRO, DANIELE; COUTO, DAYVID; LIMA, DUANE; MOREIRA, MARINA; DALCIN, EDUARDO; RAMOS, ELIANA; LÍRIO, ELTON; SALIMENA, FÁTIMA; DE OLIVEIRA, FELIPE; FRAGA, FERNANDA; TORRES-LEITE, FILIPE; ANTAR, GUILHERME; SHIMIZU, GUSTAVO; LIMA, HAROLDO; CARRIJO, TATIANA; MEDEIROS, HERISON; LUBER, JAQUELINI; CHRIST, JHENIFFER; LANNA, JOÃO; ZORZANELLI, JOÃO PAULO; FREITAS, JOELCIO; PASTORE, JOSÉ; MELO, JOSÉ; PAULA-SOUZA, JULIANA; OLIVEIRA, JULIANA; LOHMANN, LÚCIA; PEDERNEIRAS, LEANDRO; FREITAS, LEANDRO; GIACOMIN, LEANDRO; MEIRELES, LEONARDO; SILVA, LUIS; PINTO, LUIZ; MENINI NETO, LUIZ; TROVÓ, MARCELO; GARBIN, MÁRIO; MORIM, MARLI; LOBÃO, ADRIANA; RIBEIRO, MICHEL; PENA, NELSON; LABIAK, PAULO; CARDOSO, PEDRO; VIANA, PEDRO; MORAES, PEDRO; MORAES, QUÉLITA; ZORZANELLI, RAQUEL; AMARAL, RENARA; ASPRINO, RENATA; SCHEIDEGGER, ALANA; Renato Goldenberg; MAGNAGO, RICARDO; COUTO, RICARDO; DUTRA, SANDRINE; HOYOS-GÓMEZ, SAÚL; VIEIRA, TAMARA; FLORES, THIAGO; DUTRA, VALQUÍRIA; MIRANDA, VÍCTOR; MANHÃES, VITOR; FIRMINO, ALINE; FORZZA, RAFAELA; DE MELO SILVA, ALINE; NEPOMUCENO, ÁLVARO
BIODIVERSITY DATA JOURNAL, v. 10, p. e75910 2022 DOI
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The Atlantic Forest is one of the most threatened biomes in the world. Despite that, this biome still includes many areas that are poorly known floristically, including several protected areas, such as the "Floresta Nacional do Rio Preto" ("Flona do Rio Preto"), located in the Brazilian State of Espírito Santo. This study used a published vascular plant species list for this protected area from the "Catálogo de Plantas das Unidades de Conservação do Brasil" as the basis to synthesise the species richness, endemism, conservation and new species occurrences found in the "Flona do Rio Preto".The published list of vascular plants was based on field expeditions conducted between 2018 and 2020 and data obtained from herbarium collections available in online databases. Overall, 722 species were documented for the "Flona do Rio Preto", 711 of which are native to Brazil and 349 are endemic to the Atlantic Forest. In addition, 60 species are geographically disjunct between the Atlantic and the Amazon Forests. Most of the documented species are woody and more than 50% of these are trees. Twenty-three species are threatened (CR, EN and VU), while five are Data Deficient (DD). Thirty-two species are new records for the State of Espírito Santo. Our results expand the knowledge of the flora of the Atlantic Forest and provide support for the development of new conservation policies for this protected area.
KRETZSCHMAR, GABRIELA CANALLI; TARGA, ADRIANO D. S.; SOARES-LIMA, SHEILA COELHO; DOS SANTOS, PRISCILA IANZEN; RODRIGUES, LAIS S.; MACEDO, DANIEL A.; RIBEIRO PINTO, LUIS FELIPE; LIMA, MARCELO M. S.; Angelica Beate Winter Boldt
Genes, v. 13, n. 12, p. 2397 2022 DOI
Palavra-chave: Ácido Fólico; Vitamina B12; Doença de Parkinson; kinureninase; expressao gênica; metilação do DNA
Áreas do conhecimento: Ciências Biológicas; Epigenética; Ciências Biológicas; Genética; Genética Humana e Médica; Imunogenética
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Gabriela Canalli Kretzschmar; Adriano Dias Targa; Sheila Coelho Soares-Lima; Priscila Ianzen dos Santos; Laís Soares Rodrigues; Daniel A. Macedo; Luis Felipe Ribeiro Pinto; Marcelo M. S. Lima; Angelica Beate Winter Boldt
Genes, v. 13, n. 12, p. 2397 2022 DOI Home page
Palavra-chave: Tryptophan pathway; DNA methylation; gene expression; Neurodegenerative diseases; Cognitive impairment
Áreas do conhecimento: Ciências Biológicas; Fisiologia; Neurofisiologia
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