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Publicações - ciências biológicas

Gene Flow Patterns of the Aedes aegypti (Diptera: Culicidae) Mosquito in Colombia: a Continental Comparison Suggests Multiple Invasion Routes and Gene Exchange VALENCIA-MARÍN, BRYAN STEVEN; Oscar Alexander Aguirre-Obando; Mário Antonio NavarroSilva Revista Brasileira de Entomologia (Impresso), v. 66, n. 3, p. 1-11, 2022 DOI Palavra-chave: Diptera; Culicidae; Aedes aegypti; DNA mitocondrial Áreas do conhecimento: Ciências Biológicas; Zoologia; Zoologia Aplicada; Conservação das Espécies Animais; Ciências Biológicas; Zoologia; Fisiologia dos Grupos Recentes resumo ...
Genetic Associations and Differential mRNA Expression Levels of Host Genes Suggest a Viral Trigger for Endemic Pemphigus Foliaceus HOCH, VALÉRIA BUMILLER-BINI; FRANKE, ANDRE; PFÖHLER, CLAUDIA; WORM, MARGITTA; VAN BEEK, NINA; GOEBELER, MATTHIAS; SÁRDY, MIKLÓS; IBRAHIM, SALEH; BUSCH, HAUKE; SCHMIDT, ENNO; HUNDT, JENNIFER ELISABETH; KOHLER, ANA FLÁVIA; Petzl-Erler, M L; Augusto, Danillo G.; LOBO-ALVES, SARA CRISTINA; Danielle Malheiros Ferreira; CIPOLLA, GABRIEL ADELMAN; Boldt, Angelica Beate Winter; Braun-Prado, Karin; WITTIG, MICHAEL; et.al Viruses-Basel, v. 14, n. 5, p. 879 2022 DOI Palavra-chave: Pemphigus; viruses; gene expression; Fogo selvagem; genetic association Áreas do conhecimento: Ciências Biológicas; Genética Humana e Médica; Ciências Biológicas; Imunologia; Imunogenética resumo ...
Genetic Associations and Differential mRNA Expression Levels of Host Molecules suggest a Viral Trigger for Endemic Pemphigus Foliaceus Valéria Bumiller-Bini Hoch; Andre Franke; Claudia Pföhler; Margitta Worm; Nina van Beek; Matthias Goebeler; Miklós Sárdy; Saleh Ibrahim; Hauke Busch; Jennifer Elisabeth Hundt; Patrícia S A Souza; Ana Flávia Kohler; Petzl-Erler, Maria Luiza; danillo gardenal augusto; Sara Cristina Lobo-Alves; Danielle Malheiros; Gabriel Adelman Cipolla; Angelica Beate Winter Boldt; Karin Braun-Prado; Michael Wittig Viruses-Basel, v. 14, p. 879 2022 DOI Palavra-chave: pênfigo foliáceo; virus; polimorfismo; haplótipo; IRF8; TRIM5 Áreas do conhecimento: Ciências Biológicas; Genética Humana e Médica; Ciências Biológicas; Genética; Genética Humana e Médica; Imunogenética resumo ... The long search for the environmental trigger of the endemic pemphigus foliaceus (EPF, fogo selvagem) has not yet resulted in any tangible findings. Here, we searched for genetic associations and the differential expression of host genes involved in early viral infections and innate antiviral defense. Genetic variants could alter the structure, expression sites, or levels of the gene products, impacting their functions. By analyzing 3063 variants of 166 candidate genes in 227 EPF patients and 194 controls, we found 12 variants within 11 genes associated with differential susceptibility (p < 0.005) to EPF. The products of genes TRIM5, TPCN2, EIF4E, EIF4E3, NUP37, NUP50, NUP88, TPR, USP15, IRF8, and JAK1 are involved in different mechanisms of viral control, for example, the regulation of viral entry into the host cell or recognition of viral nucleic acids and proteins. Only two of nine variants were also associated in an independent German cohort of sporadic PF (75 patients, 150 controls), aligning with our hypothesis that antiviral host genes play a major role in EPF due to a specific virus–human interaction in the endemic region. Moreover, CCL5, P4HB, and APOBEC3G mRNA levels were increased (p < 0.001) in CD4+ T lymphocytes of EPF patients. Because there is limited or no evidence that these genes are involved in autoimmunity, their crucial role in antiviral responses and the associations that we observed support the hypothesis of a viral trigger for EPF, presumably a still unnoticed flavivirus. This work opens new frontiers in searching for the trigger of EPF, with the potential to advance translational research that aims for disease prevention and treatment.
Glycoside hydrolase subfamily GH5_57 features a highly redesigned catalytic interface to process complex hetero-β-mannans MARTINS, MARCELE P.; Silveira, Joana L. M.; LOMBARD, VINCENT; TERRAPON, NICOLAS; DUPREE, PAUL; HENRISSAT, BERNARD; MURAKAMI, MÁRIO T.; MORAIS, MARIANA A. B.; PERSINOTI, GABRIELA F.; GALINARI, RAFAEL H.; YU, LI; YOSHIMI, YOSHIHISA; PASSOS NUNES, FERNANDA B.; LIMA, TATIANI B.; BARBIERI, SHAYLA F. Acta Crystallographica Section D-Structural Biology, v. 78, n. 11, p. 1358-1372, 2022 DOI Palavra-chave: endo-β-mannanases; crystal structure; heteromannans; glycoside hydrolase GH5 family Áreas do conhecimento: Ciências Biológicas; Bioquímica dos Microorganismos; Enzimologia resumo ...
Gradual increase of temperature trigger metabolic and oxidative responses in plasma and body tissues in the Antarctic fish Notothenia rossii GUILLEN, ANGELA CAROLINA; BORGES, MARCELO EDUARDO; HERRERIAS, TATIANA; KANDALSKI, PRISCILA KREBSBACH; DE SOUZA, MARIA ROSA DMENGEON PEDREIRO; Donatti, Lucélia FISH PHYSIOLOGY AND BIOCHEMISTRY, v. 48, p. 337-354, 2022 DOI Palavra-chave: Antarctica; fish antarctic Áreas do conhecimento: Ciências Biológicas; Ecologia; Ecologia de Ecossistemas; Ciências Biológicas; Bioquímica; Bioquímica resumo ...
Heteroleptic oxidovanadium(IV)-malate complex improves glucose uptake in HepG2 and enhances insulin action in streptozotocin-induced diabetic rats DE NIGRO, THANISE PITELLI; PICHETH, GERALDO; REGO, FABIANE GOMES DE MORAES; MANICA, GRACIELE CRISTIANE MORE; DE SOUZA, SUSAN WEBBER; JESUS, CARLOS HENRIQUE ALVES; BOTTINI, RÚBIA CAMILA RONQUI; MISSINA, JULIANA MORAIS; VALDAMERI, GLAUCIO; NUNES, GIOVANA GIOPPO; Cunha, Joice M. BIOMETALS, v. 1, p. 1 2022 DOI Palavra-chave: diabetes Áreas do conhecimento: Ciências Biológicas; Farmacologia; Farmacologia Geral resumo ... Diabetes mellitus, a complex and heterogeneous disease associated with hyperglycemia, is a leading cause of mortality and reduces life expectancy. Vanadium complexes have been studied for the treatment of diabetes. The effect of complex [VO(bpy)(mal)]·H2O (complex A) was evaluated in a human hepatocarcinoma (HepG2) cell line and in streptozotocin (STZ)-induced diabetic male Wistar rats conditioned in seven groups with different treatments (n = 10 animals per group). Electron paramagnetic resonance and 51V NMR analyses of complex A in high-glucose Dulbecco’s Modified Eagle Medium (DMEM) revealed the oxidation and hydrolysis of the oxidovanadium(IV) complex over a period of 24 h at 37 °C to give low-nuclearity vanadates “V1” (H2VO4−), “V2” (H2V2O72−), and “V4” (V4O124−). In HepG2 cells, complex A exhibited low cytotoxic effects at concentrations 2.5 to 7.5 μmol L−1 (IC50 10.53 μmol L−1) and increased glucose uptake (2-NBDG) up to 93%, an effect similar to insulin. In STZ-induced diabetic rats, complex A at 10 and 30 mg kg−1 administered by oral gavage for 12 days did not affect the animals, suggesting low toxicity or metabolic impairment during the experimental period. Compared to insulin treatment alone, complex A (30 mg kg−1) in association with insulin was found to improve glycemia (30.6 ± 6.3 mmol L−1 vs. 21.1 ± 8.6 mmol L−1, respectively; p = 0.002), resulting in approximately 30% additional reduction in glycemia. The insulin-enhancing effect of complex A was associated with low toxicity and was achieved via oral administration, suggesting the potential of complex A as a promising candidate for the adjuvant treatment of diabetes.
High Melanin Content in Melanoma Cells Contributes to Enhanced DNA Damage after Rose Bengal Photosensitization KALEGARI, PALOMA; LEME, DANIELA MORAIS; DISNER, GEONILDO RODRIGO; Cestari, M.M.; LIMA BELLAN, DANIEL; MEIRA, WILLIAN VANDERLEI; MAZEPA, ESTER; MARTINEZ, GLAUCIA REGINA PHOTOCHEMISTRY AND PHOTOBIOLOGY, v. 1, p. 001-005, 2022 DOI Palavra-chave: Genotoxicidade; ensaio cometa Áreas do conhecimento: Ciências Biológicas; Genética; genotoxicidade resumo ...
HLA-G and CD152 Expression Levels Encourage the Use of Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells as an Alternative for Immunosuppressive Therapy Bernardo Zoehler; Leticia Fracaro; Lidiane Maria Boldrini Leite; Paul Travers; Roberto Slud Brofman; Alexandra Cristina Senegaglia; BICALHO, M. G. Cells, v. 14;11(8), n. 1339, p. 1-14, 2022 Palavra-chave: HLA-G molecule; immunosuppressive molecules;; mesenchymal stromal cell; resumo ...
Immature stages of Nilio (Micronilio) pusillus Ihering, 1914 (Coleoptera: Tenebrionidae) with redescription of adults and new distributional records Bruna Pasqualinoto Macari; SILVA, JANICE B.; Almeida, LM. ANNALES ZOOLOGICI, v. 72, n. 1, p. 97-103, 2022 DOI Palavra-chave: Brazil; Darkling beetles; Larvae; Nilioninae; Pupae; Taxonomy Áreas do conhecimento: Ciências Biológicas; Zoologia; Entomologia; Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes resumo ...
Immobilization of Pseudomonas fluorescens lipase on chitosan crosslinked with polyaldehyde starch for kinetic resolution of sec-alcohols Leandro Alves Santos; Robson Carlos Alnoch; Gleydison Amarante Soares; MITCHELL, DAVID ALEXANDER; KRIEGER, NADIA PROCESS BIOCHEMISTRY, v. 122, p. 238-247, 2022 DOI Palavra-chave: lipase; imobilização; Resolução de misturas racêmicas; Pseudomonas fluorescens Áreas do conhecimento: Ciências Biológicas; Bioquímica; Bioquímica dos Microorganismos; Biotecnologia; Ciências Biológicas; Bioquímica; Enzimologia resumo ...

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