Publicações - ciências biológicas
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Masahiko Ohi;
Dalsenter, Paulo Roberto;
Anderson Joel Martino Andrade;
Aguinaldo José do Nascimento
Palavra-chave:
toxicologia;
toxicologia reprodutiva;
toxicology
Áreas do conhecimento:
Ciências Biológicas; Farmacologia; Toxicologia; Toxicologia Ambiental;
Ciências Biológicas; Farmacologia; Toxicologia; Toxicologia Reprodutiva
resumo ...
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Dalsenter, Paulo Roberto;
Ana Maria Cavalcanti;
Anderson Joel Martino Andrade;
Samanta Araújo;
Maria Consuelo Andrade Marques
Palavra-chave:
Achillea millefolium L.;
Produtos Natuais;
Plantas Medicinias;
Toxicologia Pre-Clínica de Produtos Naturais;
Toxicologia Reprodutiva
Áreas do conhecimento:
Ciências Biológicas; Farmacologia; Farmacologia Geral;
Ciências Biológicas; Farmacologia; Farmacologia e Toxicologia Pré Clinica de Produtos Naturais
resumo ...
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Dalsenter, Paulo Roberto;
Anderson Joel Martino Andrade;
Samanta Araújo;
Maria Consuelo Andrade Marques
Palavra-chave:
toxicologia reprodutiva;
Aquillea millefolium;
Ratos Wistar
Áreas do conhecimento:
Ciências Biológicas; Farmacologia; Toxicologia; Toxicologia Ambiental;
Ciências Biológicas; Farmacologia; Farmacologia Geral
resumo ...
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Dalsenter, Paulo Roberto;
Ana Maria Cavalcanti;
Anderson Joel Martino Andrade;
Samanta Araújo;
Maria Consuelo Andrade Marques
Palavra-chave:
toxicologia;
toxicologia reprodutiva;
toxicology
Áreas do conhecimento:
Ciências Biológicas; Farmacologia; Toxicologia; Toxicologia Ambiental;
Ciências Biológicas; Farmacologia; Toxicologia; Toxicologia Ambiental
resumo ...
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Edilene Alcântara de Castro;
Felipe Pohl de Souza;
Sotomaior, Cristina Santos;
Viviane Milczewski;
Giovani Mocelin;
Maria do Carmo Pessôa e Silva;
Edilene Alcântara de Castro
Brazilian Archives of Biology and Technology,
v. 47,
p. 41-47,
2004
Áreas do conhecimento:
CIENCIAS_AGRARIAS; Medicina Veterinária; Patologia Animal; Patologia Clínica Animal;
Ciências Biológicas; Parasitologia; Helmintologia de Parasitos
resumo ...
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Maristela Azevedo;
Marta Marques de Souza;
Carolina Arruda de Oliveira Freire
Palavra-chave:
aquacultura;
Nitrito;
Tilápia
Áreas do conhecimento:
Ciências Biológicas; Fisiologia Comparada; Fisiologia Aviária;
Ciências Biológicas; Ecologia; Ecologia Aplicada
resumo ...
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Schmitt, R.;
Sandro Luis Bonatto;
Freitas, L. B.;
Muschner, V. C.;
Hill, K.;
Hurtado, A. M.;
Francisco Mauro Salzano
Palavra-chave:
ACHE;
mtDNA
Áreas do conhecimento:
Ciências Biológicas; Genética Evolutiva;
Ciências Biológicas; Genética; Genética Humana e Médica; Imunogenética
resumo ...
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Giusti-Paiva, Alexandre;
Maria Regina Martinez;
Cestari Felix, Jorge Vinicius;
da Rocha, Maria Jose Alves;
Carnio, Evelin Capellari;
Lucila Leico Kagohara Elias;
Antunes-Rodrigues, Jose;
Jorge Vinícius Cestari Felix
resumo ...
lutaryl coenzyme A reductase (HMG-CoA reductase), in addition to lowering serum cholesterol levels, exert many pleiotropic effects, including anti-inflammatory action. In the present study, we investigated the effect of simvastatin, an HMG-CoA reductase inhibitor, on the production of nitric oxide and the cardiovascular response to LPS. Male Wistar rats were pretreated with different doses of simvastatin (10, 20, 40, and 80 mg/kg, i.p.) or saline 20 min before i.v. injection of LPS (1.5 mg/kg) or saline (control). MAP was continuously recorded and nitrate plasma concentration was determined during the 6-h experimental session at 1-h intervals. The pressor response to phenylephrine (1 μg/kg) was evaluated before and 6 h after LPS administration. In the LPS-treated group, there was a time-dependent increase in nitrate plasma concentration (P < 0.001), and this response was decreased in simvastatin pretreated rats (P < 0.001). We also observed that LPS decreased the pressor response to phenylephrine (P < 0.001), an effect that was reverted by simvastatin pretreatment (P < 0.05). However, simvastatin did not modify the decrease of MAP induced by LPS. We concluded that simvastatin decreases nitrate plasma concentration in response to LPS and recovers vascular responsiveness during an experimental endotoxic shock. These data suggest the potential use of HMG-CoA reductase inhibitors as a coadjuvant in the treatment of septic shock....
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Sayuri Miyamoto;
MARTINEZ, GLAUCIA REGINA;
Marisa Helena Gennari Medeiros;
Paolo Di Mascio
Free Radical Biology and Medicine,
v. 36,
p. 28
2004
Áreas do conhecimento:
Ciências Biológicas; Bioquímica; Fotobiologia; Oxigênio Singlete
resumo ...
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Jean-Luc Ravanat;
S Sauvaigo;
S Caillat;
MARTINEZ, GLAUCIA REGINA;
Marisa Helena Gennari Medeiros;
Paolo Di Mascio;
A Favier;
Jean Cadet
Áreas do conhecimento:
Ciências Biológicas; Metabolismo e Bioenergética; Lesão Em Dna Por Oxigênio Singlete;
Ciências Biológicas; Bioquímica; Química de Macromoléculas
resumo ...
The damage profile produced by the reaction of singlet molecular oxygen with cellular DNA was determined using the comet assay associated with DNA repair enzymes. Singlet oxygen was produced intracellularly by thermal decomposition of a watersoluble endoperoxide of a naphthalene derivative which is able to penetrate through the membrane into mammalian cells. We found that the DNA modifications produced by singlet oxygen were almost exclusively oxidised purines recognised by the formamidopyrimidine DNA N-glycosylase. In contrast, significant amounts of direct strand breaks and alkalilabile sites or oxidised pyrimidines, detectable by the bacterial endonuclease III, were not produced.
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