Guia de fontes

Publicações - ciências biológicas

The evolution of Bolbites onitoides (Coleoptera: Scarabaeidae: Phanaeini): its phylogenetic significance, geographical polychromatism and the subspecies problem MARIO CUPELLO; Cibele Stramare Ribeiro-Costa; Fernando Vaz de Melo ZOOLOGICAL JOURNAL OF THE LINNEAN SOCIETY, v. 1, p. 1-62, 2022 DOI Palavra-chave: Taxonomy; morphology; Scarabaeidae Áreas do conhecimento: Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes resumo ... Abstract. The distribution of the iridescent dung beetle Bolbites onitoides can be divided, based on dorsal colouration, into a blue western-half and a red
The interplay between uremic toxins and albumin, membrane transporters and drug interaction Regiane Stafim da Cunha; Carolina Amaral Bueno Azevedo; Carlos Alexandre Falconi; Fernanda Fogaça Ruiz; Sophie Liabeuf; Marcela Sorelli Carneiro-Ramos; Andréa Emília Marques Stinghen Toxins, v. 14, p. 1-24, 2022 DOI Palavra-chave: Uremic Toxins; Drugs; Membrane Transporters; Albumin Áreas do conhecimento: Ciências da Saúde; Medicina; Clínica Médica; Nefrologia; Ciências Biológicas; Bioquímica; Bioquímica resumo ... Uremic toxins are a heterogeneous group of molecules that accumulate in the body due to the progression of chronic kidney disease (CKD). These toxins are associated with kidney dysfunction and the development of comorbidities in patients with CKD, being only partially eliminated by dialysis therapies. Importantly, drugs used in clinical treatments may affect the levels of uremic toxins, their tissue disposition, and even their elimination through the interaction of both with proteins such as albumin and cell membrane transporters. In this context, protein-bound uremic toxins (PBUTs) are highlighted for their high affinity for albumin, the most abundant serum protein with multiple binding sites and an ability to interact with drugs. Membrane transporters mediate the cellular influx and efflux of various uremic toxins, which may also compete with drugs as substrates, and both may alter transporter activity or expression. Therefore, this review explores the interaction mechanisms between uremic toxins and albumin, as well as membrane transporters, considering their potential relationship with drugs used in clinical practice.
The Potential of NORAD-PUMILIO-RALGAPB Regulatory Axis as a Biomarker in Breast Cancer MULLER, CRISTIANE SATO MARA; GINER, IGOR SAMESIMA; ZAMBALDE, ERIKA PEREIRA; CARVALHO, TAMYRES MINGORANCE; RIBEIRO, ENILZE MARIA DE SOUZA FONSECA; CARVALHO DE OLIVEIRA, JAQUELINE; MATHIAS, CAROLINA; Daniela Fiori Gradia Non-Coding Rna, v. 8, n. 6, p. 76 2022 DOI Palavra-chave: lncRNA; NORAD; Pumilio proteins; RALGAPB; Breast cancer; Biomarkers Áreas do conhecimento: Ciências Biológicas; Genética Humana e Médica resumo ... Introduction: Long non-coding RNAs (LncRNA) represent a heterogeneous family of RNAs that have emerged as regulators of various biological processes through their association with proteins in ribonucleoproteins complexes. The dynamic of these interactions can affect cell metabolism, including cancer development. Annually, breast cancer causes thousands of deaths worldwide, and searching for new biomarkers is pivotal for better diagnosis and treatment. Methods: Based on in silico prediction analysis, we focus on LncRNAs that have binding sites for PUMILIO, an RBP family involved in post-transcriptional regulation and associated with cancer progression. We compared the expression levels of these LncRNAs in breast cancer and non-tumor samples from the TCGA database. We analyzed the impact of overall and disease-free survival associated with the expression of the LncRNAs and co-expressed genes and targets of PUMILIO proteins. Results: Our results found NORAD as the most relevant LncRNA with a PUMILIO binding site in breast cancer, differently expressed between Luminal A and Basal subtypes. Additionally, NORAD was co-expressed in a Basal-like subtype (0.55) with the RALGAPB gene, a target gene of PUMILIO related to chromosome stability during cell division. Conclusion: These data suggest that this molecular axis may provide insights for developing novel therapeutic strategies for breast cancer.
The Role of H2O2-Scavenging Enzymes (Ascorbate Peroxidase and Catalase) in the Tolerance of Lemna minor to Antibiotics: Implications for Phytoremediation GOMES, MARCELO PEDROSA; KITAMURA, RAFAEL SHINJI AKIYAMA; MARQUES, RAIZZA ZORMAN; Marcello Locatelli Barbato; ZÁMOCKÝ, MARCEL ANTIOXIDANTS, v. 11, n. 1, p. 151 2022 DOI Áreas do conhecimento: Ciências Biológicas; Biologia Molecular; Ciências Biológicas; Bioquímica; Bioquímica resumo ...
The Spittlebug Mahanarva tristis as a Senior Synonymy of Four Neotropical Species of Mahanarva (Hemiptera: Auchenorrhyncha: Cercopidae), and Considerations About M. tristis Subspecies SCHÖBEL, CHRISTIAN; Gervásio Silva Carvalho; Andressa Paladini; TEIXEIRA, RENATO AUGUSTO NEOTROPICAL ENTOMOLOGY, v. 1, p. 1 2022 DOI Palavra-chave: Paramere; Angles; Tegmina; color polymorphism; Taxon Áreas do conhecimento: Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes; Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes; Sistemática resumo ...
Thermal stability and degradation of meso-tetraphenylporphyrins bearing nitrogen-containing substituents CARNEIRO, JAQUELINE; DALLAGNOL, JULIANA C. C.; VEIGA, ANDRESSA; Miguel Noseda; Duarte, Maria Eugênia R.; FILHO, MARCO A. CARVALHO; Diogo R. B. Ducatti; Alan Guilherme Gonçalves; MURAKAMI, FÁBIO S. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, v. 147, n. 12, p. 6755-6764, 2022 DOI Palavra-chave: Porphyrins; Chemical modifications; Chemical Structure Áreas do conhecimento: Ciências Biológicas; Bioquímica; Biotecnologia resumo ...
Three names, one species: junior synonyms for the Atlantic Forest emerald dragonfly Navicordulia atlantica (Odonata: Corduliidae s.s.) Pinto, Ângelo P.; Ângelo Parise Pinto; Marcus Vinícius Oliveira De Almeida; EHLERT, JULIANA Revista Brasileira de Entomologia (Impresso), v. 66, p. 1-14, 2022 DOI Palavra-chave: Anisoptera; Libelluloidea; Corduliinae; new synonymies; Species delimitation Áreas do conhecimento: Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes; Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes resumo ... ABSTRACT Three Atlantic Forest endemic species of emerald dragonflies of the genus Navicordulia...
Transcribed Ultraconserved Regions Are Associated with Clinicopathological Features in Breast Cancer ZAMBALDE, ERIKA PEREIRA; ADAMOSKI, DOUGLAS; Daniela Fiori Gradia; RABINOVICH, IRIS; RODRIGUES, ANA CAROLINA; IVAN, CRISTINA; RIBEIRO, ENILZE M. S. F.; CALIN, GEORGE ADRIAN; CARVALHO DE OLIVEIRA, JAQUELINE BIOMOLECULES, v. 12, n. 2, p. 214 2022 DOI Palavra-chave: T-UCRs; Breast cancer; lncRNA Áreas do conhecimento: Ciências Biológicas; Genética Humana e Médica resumo ... Ultraconserved regions (UCRs) are 481 genome segments, with length longer than 200 bp, that are 100% conserved among humans, mice, and rats. The majority of UCRs are transcriptionally active (T-UCRs) as many of them produce non-coding RNAs. In a previous study, we evaluated the expression level of T-UCRs in breast cancer (BC) patients and found that 63% of transcripts correlated with some clinical and/or molecular parameter of BC. In this study, we delved into the expression levels of 12 T-UCRs and correlated them with clinicopathological parameters, immunohistochemical markers, and overall survival in two breast cancer cohorts: TCGA and Brazilian patients. We found that uc.268 is more expressed in TCGA patients under 40 years of age, associated with progesterone receptor (PR) and estrogen receptor (ER), and its high expression is found in luminal A. Lower uc.84 and uc.376 were respectively observed in metastatic and stage IV tumors associated with good prognostic in luminal B. Moreover, uc.84 was only related to the HER2+, while uc.376 was related to ER+ and PR+, and HER2+. A panel composed of uc.147, uc.271, and uc.427 distinguished luminal A from triple negative patients with an AUC of 0.9531 (sensitivity 92.19% and specificity 86.76%). These results highlight the potential role of T-UCRs in BC and provide insights into the potential application of T-UCRs as biomarkers.
Two New Endemic Tetraploid Species of the Genus from the Brazilian Savanna Jovani B.S. Pereira; Jefferson Prado SYSTEMATIC BOTANY, v. 47, p. 301-305, 2022 DOI Palavra-chave: Cerrado; Heterosporous plants; lycophytes; Polyploids; South America Áreas do conhecimento: Ciências Biológicas; Botânica; Taxonomia Vegetal; Taxonomia de Criptógamos resumo ...
Uniparental markers reveal new insights on subcontinental ancestry and sex-biased admixture in Brazil JOERIN-LUQUE, IRIEL A.; Augusto, Danillo G.; CALONGA-SOLÍS, VERÓNICA; DE ALMEIDA, RODRIGO COUTINHO; LOPES, CLAUDEMIRA VIEIRA GUSMÃO; Maria Luiza Petzl-Erler; BELTRAME, MARCIA HOLSBACH MOLECULAR GENETICS AND GENOMICS, v. 297, n. 2, p. 419-435, 2022 DOI Palavra-chave: Genetic polymorphism; ancestry markers; uniparental markers; Brazilian population Áreas do conhecimento: Ciências Biológicas; Genética Humana e Médica resumo ...

Total de registros: 10924