Publicações - ciências biológicas
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GODOY, JULIANA BEKER;
BENNETT, DAVID A.;
Dieval Guizelini;
DE PAIVA LOPES, KATIA;
VIALLE, RICARDO A.;
DOS SANTOS, LOREN;
RAITTZ, ROBERTO T.;
WANG, YANLING;
MENON, VILAS;
DE JAGER, PHILIP L.;
SCHNEIDER, JULIE A.;
TASAKI, SHINYA
Palavra-chave:
Alzheimer?s disease;
Biomarkers;
Cytokines;
Neuroinflammation;
Single-nuclei RNA-Seq;
transcriptomics
Áreas do conhecimento:
Ciências Biológicas; Bioquímica; Bioinformática
resumo ...
Alzheimer’s disease (AD) is a complex neurodegenerative condition linked to chronic neuroinflammation. This study investigates the cytokine gene expression profile in cortical tissue samples from elderly individuals with and without AD to identify potential biomarkers and enhance our understanding of disease pathogenesis. Utilizing high-depth RNA sequencing data, we identified a set of cytokines whose expression significantly associated with different aspects of the AD phenotype, including measures of neurofibrillary tangles, amyloid-β deposition, and a person-specific rate of cognitive decline. Single-nucleus transcriptomics data facilitated the identification of specific cell types, such as microglia and astrocytes, that significantly contribute to the inflammatory response in AD. Additionally, we observed a correlation between the expression of certain cytokines and genetic risk for the disease. Our findings indicate that cytokine-mediated neuroinflammation may play an important role in neurodegeneration and that modulating the immune response may offer a promising strategy for developing new therapies.
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DE SOUZA AMORIM, DALTON;
COURI, MÁRCIA S.;
FACHIN, DIEGO A.;
FLORES, HELOISA F.;
GOMES, MARINA;
KORNEYEV, VALERY;
LONSDALE, OWEN;
MARINHO, MARCO A.T.;
MENGUAL, XIMO;
NORRBOM, ALLEN L.;
OTT, TAÍS MADEIRA;
BROWN, BRIAN V.;
RAFAEL, JOSÉ ALBERTINO;
ANG, YUCHEN;
BALBI, MARIA ISABEL P.A.;
BHATTARAI, SHIVA SHANKAR;
Rosaly Ale-Rocha;
CAPELLARI, RENATO S.;
CARMO, DANIEL D.D.;
Cláudio J B Carvalho;
et.al
Palavra-chave:
biodiversity;
Muscidae;
Biogeography
Áreas do conhecimento:
Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes;
Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes;
Ciências Biológicas; Zoologia; Biogeografia
resumo ...
(en)
The Diptera fauna of a small area in Samundradevi, north of Kathmandu, at 1,890 m, was sampled during an expedition, resulting in records of 54 families, of which 176 genera could be recognized. These are the first records for Nepal of 12 fly families—Anisopodidae, Diadocidiidae, Neriidae, Lonchaeidae, Platystomatidae, Piophilidae, Strongylophthalmidae, Diopsidae, Anthomyzidae, Clusiidae, Camillidae, and Stenomicridae—and 86 genera. Our samples from Samundradevi are dominated by Oriental Region elements—while sites with similar altitudes in Nepal or much more to the south in Asia used to have a higher proportion of typically Palearctic components. The possibly complete or nearly complete ice coverage of the Shivapuri Mountain Range along the last glaciation cycle may have entirely wiped out the previous fauna and flora, dominated by Palearctic elements, that would have been replaced more recently by the surrounding Oriental elements.
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SAMPAIO, ANDRÉ;
CARNEIRO, JAQUELINE;
FURMAN, GIOVANNA;
PICHETH, GUILHERME F.;
GERHARDT, EDILEUSA M.;
MÜLLER-SANTOS, MARCELO;
CHUBATSU, LEDA;
DE SOUZA, EMANUEL MALTEMPI;
TODO BOM, MARITZA ARAUJO;
BUDEL, MARIA L. T.;
WENDLER MIRANDA, BRENNO;
DIAS, ISABELA P.;
FILHO, RAFAEL X. V.;
CASANI CARDOSO, GABRIELA;
Edneia Amancio de Souza Ramos Cavalieri;
JACUMAZO, JOSLAINE
Palavra-chave:
nanopartículas
Áreas do conhecimento:
Ciências Biológicas; Biotecnologia; Biotecnologia em Saúde Humana e Animal; Vacinas e Kits para Diagnósticos
resumo ...
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ROCHA, G. S.;
Ana Teresa Lombardi;
Evaldo G. Espindola
Palavra-chave:
ecotoxicologia;
metais traco
resumo ...
Metal discharges from anthropogenic activities are of great concern, and the effects of metallic mixtures in aquatic environments are still not fully understood. This study aimed to evaluate the effects of cadmium (Cd) and copper (Cu), isolated and combined, in the growth and photosynthesis – photosystem II (PSII) activity (ΦPSII = Fv/FM), effective quantum yield, photochemical (qP) and non-photochemical quenching (qN and NPQ), and quenchings of regulated ((Y(NPQ)) and non-regulated ((Y(NO)) non-photochemical energy loss in photosystem II, in addition to the rapid light curves of the freshwater green microalga Ankistrodesmus densus. Both metals affected algal physiology and when combined most of the responses were antagonists, i.e., the observed effects were lower than those predicted for the mixture. The contaminants decreased the chlorophyll a production, photosynthetic activity, and increased heat dissipation, suggesting activation of the photoprotection mechanisms and with no evidence of photoprotection damage in the algae. Except for Y(NO), all evaluated photosynthetic parameters were sensitive indicators of the changes observed in microalgae under Cd and Cu exposure, isolated or combined. In addition, we suggest that algal protective mechanisms were efficient to decrease the impact of the combination of metals, reinforced by the increases in qN, NPQ and Y(NPQ), resulting mainly in antagonism in photosynthetic parameters.
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STICA, PAULA VALESKA;
Antonio Ostrensky Neto;
Márcio Pie;
HORODESKY, ALINE;
DALPONT, GIORGI;
COZER, NATHIELI;
BIERNASKI, VILMAR;
Netto, Otto Samuel Mäder;
SZORTYKA, ANDRÉIA;
BALDISSERA, ADRIANO
Palavra-chave:
eDNA;
Biologia Molecular;
qPCR;
LIMNOLOGIA
Áreas do conhecimento:
Ciências Exatas e da Terra; Limnologia;
Ciências Biológicas; Bioquímica; Biologia Molecular
resumo ...
The study of environmental DNA (eDNA) is a powerful tool for detecting and monitoring aquatic species, but sample preservation methods can critically affect analytical outcomes. Here, we examined the impact of freezing water samples—before filtration and DNA extraction—on eDNA degradation under controlled mesocosm conditions with two aquatic species: Nile tilapia (Oreochromis niloticus) and golden mussel (Limnoperna fortunei). Our findings demonstrated that freezing duration significantly reduced eDNA concentration, with a biphasic degradation pattern characterised by rapid initial loss followed by a slower degradation rate. In contrast, freezing speed did not significantly affect eDNA concentration, suggesting that the freezing process itself, rather than its speed, is the primary driver of eDNA degradation. These results highlight the importance of minimising freezing time for eDNA preservation and suggest that prioritising freezing duration over speed is sufficient in settings where rapid freezing may not be feasible. This study provides significant observations about the patterns and extent of eDNA degradation and offers practical guidelines for optimising eDNA sample processing. By understanding and mitigating the factors affecting eDNA viability, researchers can improve the accuracy and reliability of eDNA-based monitoring programmes, thereby enhancing efforts to protect and manage aquatic biodiversity.
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GONÇALVES, AMANDA DE MESQUITA;
CERBONCINI, RICARDO AUGUSTO SERPA;
Fernando Willyan Trevisan Leivas;
BARROSO, PAULO RICARDO RAMIRES;
KLEMANN JUNIOR, LOURI
Palavra-chave:
Floresta Amazônica;
ecologia;
Histerídeo;
indicadores biológicos
Áreas do conhecimento:
Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes
resumo ...
(en)
Insects that respond quickly to environmental disturbances may allow the monitoring of the impacts of human activities on natural ecosystems. We aimed at testing the effects of reduced-impact selective logging on histerid beetles in the Brazilian Amazon. We identified potential indicator species of logged and unlogged sites and tested the effects of time after logging, seasonality, and logging intensity on species richness, number of individuals captured, and assemblage structure. We used 240 flight interception traps to sample one unlogged site and 11 sites with different years after logging. Diversity estimates were affected by seasonality, time after logging, and logging intensity. Twelve species were indicators of the unlogged site. Species richness and the number of individuals captured decreased in the logged sites. Our results suggest that histerid beetle assemblages responded quickly to the disturbance and they may be used as bioindicators.
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GERMANO, KELLY DE OLIVEIRA;
DE SOUZA, LUCAS ALEXANDRE FARIAS;
DO AMARAL, ANA MARGARIDA RIBEIRO;
Honório, Nildimar Alves;
CAMARA, TAMARA LIMA;
Magda Clara Vieira da Costa Ribeiro
Palavra-chave:
Aedes aegypti;
dormancy;
climate;
Diapause;
Quiescence;
Survivorship
Áreas do conhecimento:
Ciências Biológicas; Parasitologia; Entomologia e Malacologia de Parasitos e Vetores
resumo ...
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Danilo A. Zavatin;
Renato Ramos;
Jefferson Prado;
Arthur Sousa Soares;
Marcelo Monge;
Raymond M. Harley
Palavra-chave:
campos rupestres;
endemism;
Labiatae;
Nepetoideae;
Ocimeae
Áreas do conhecimento:
Ciências Biológicas; Botânica; Taxonomia Vegetal; Taxonomia de Fanerógamos
resumo ...
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MOREIRA SILVA, ENZO ZINI;
RODRIGUES, ANA CAROLINA;
KOHLER, ANA FLÁVIA;
CRUZ, JULIANA VARELLA;
PRADO, KARIN BRAUN;
Daniela Fiori Gradia;
DE OLIVEIRA, DANIELLE PALMA;
PESTANA, CYNTHIA BOMFIM;
LEME, DANIELA MORAIS
Palavra-chave:
Organophosphorus flame retardants;
Reconstructed human epidermis;
In silico prediction;
Immortalized human keratinocyte;
Cytokine release;
DNA methylation
Áreas do conhecimento:
Ciências Biológicas; Biotecnologia; Biotecnologia em Saúde Humana e Animal; Metodologias Alternativas ao Uso de Animais
resumo ...
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KAVA, VANESSA;
ORDONEZ, JUAN;
OLIVEIRA, ANNE;
MARIANO, ANDRÉ B.;
CONOR, GABRIELA;
Jóse Viriato Coelho Vargas;
MELENEK, NICHOLAS;
RAMPI, MURILO
Palavra-chave:
agricultural practices;
plant growth promoters;
mathematical model;
sustainability;
cogeneration;
exergy analysis
Áreas do conhecimento:
Engenharias; Engenharia Mecânica; Engenharia Térmica; Aproveitamento da Energia;
Ciências Biológicas; Biotecnologia; Biotecnologia Industrial
resumo ...
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