Publicações - ciências biológicas
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CORSO, CLAUDIA RITA;
QUEIROZ-TELLES, JOSÉ EDERALDO;
DE OLIVEIRA, CRISTHIAN SANTOS;
Stefanello, Maria Élida Alves;
Acco, Alexandra;
STIPP, MARIA CAROLINA;
ADAMI, ELIANA REZENDE;
DA SILVA, LUISA MOTA;
MARIOTT, MARIHÁ;
DE ANDRADE, SÉRGIO FALONI;
DE SOUZA RAMOS, EDNEIA AMANCIO;
KLASSEN, GISELI;
Beltrame, Olair Carlos
Palavra-chave:
Salvia;
Lamiaceae;
ATIVIDADE ANTITUMORAL
Áreas do conhecimento:
Ciências Exatas e da Terra; Química; Química Orgânica; Química dos Produtos Naturais;
Ciências Biológicas; Farmacologia; Farmacologia Geral
resumo ...
Salvia lachnostachys is an herbaceous plant with anti-inflammatory, analgesic and cytotoxic properties. This study investigated the antitumor effect of an ethanolic extract of Salvia lachnostachys leaves (EES) in a solid Ehrlich carcinoma model. Ehrlich cells were inoculated subcutaneously in the right pelvic member (2 × 106 cells) in female Swiss mice. The animals were treated with vehicle (10 mL kg−1, p.o.), EES (30 and 100 mg kg−1, p.o.), or methotrexate (2.5 mg kg−1, i.p.) for 21 days (early treatment) or 14 days (late treatment) after tumor inoculation, or 10 days before tumor inoculation and continued for 21 days after tumor inoculation (chemopreventive treatment). The acute toxicity test was performed according OECD guidelines Late treatment with EES had no antitumor effect. Early treatment with 100 mg kg−1 EES prevented tumor development, increased tumor necrosis factor-α (TNF-α) levels and decreased tumor superoxide dismutase (SOD) activity, interleukin-10 (IL-10) levels and Cyclin D1 expression, and tumor cell necrosis was observed. Chemopreventive treatment with EES for 10 and 31 days prevented tumor development in the same manner. EES treatment for 31 days decreased hepatic and tumor SOD activity, tumor IL-10 levels and Cyclin D1 expression, and increased tumor reduced glutathione, N-acetylglucosaminidase, reactive oxygen species, lipid peroxidation, TNF-α levels and Nrf2 expression. No toxicity was observed in the acute toxicity assay. In conclusion, EES had an antitumor effect by inhibiting Cyclin D1 expression and increasing inflammation with early and chemopreventive treatment. Modulation of the antioxidant system also contribute for the antitumor effects of EES.
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FARIAS, TICIANA DELLA JUSTINA;
Augusto, Danillo G.;
DE ALMEIDA, RODRIGO COUTINHO;
Danielle Malheiros Ferreira;
Maria Luiza Petzl-Erler
Palavra-chave:
Pemphigus;
Fogo selvagem;
leucocyte receptor complex;
19q13.42;
LRC;
genetic susceptibility
Áreas do conhecimento:
Ciências Biológicas; Genética Humana e Médica;
Ciências Biológicas; Imunologia; Imunogenética
resumo ...
Leucocyte receptor complex single nucleotide polymorphisms associated with pemphigus foliaceus are potentially implicated in gene regulation.
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FARIAS, TICIANA DELLA JUSTINA;
Augusto, Danillo G.;
DE ALMEIDA, RODRIGO COUTINHO;
Danielle Malheiros Ferreira;
Maria Luiza Petzl-Erler
Palavra-chave:
Pemphigus;
Fogo selvagem;
leucocyte receptor complex;
19q13.42;
LRC;
genetic susceptibility
resumo ...
Leucocyte receptor complex single nucleotide polymorphisms associated with pemphigus foliaceus are potentially implicated in gene regulation.
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Aline Luiza Konell;
Ana Paula Sato;
Marina Stival;
Nathalia Parreira Malaguini;
Alan dos Anjos;
Rafaela furioso Ferreira;
Rosangela Locatelli Dittrich
REVISTA BRASILEIRA DE PARASITOLOGIA VETERINARIA,
v. 28,
n. 2,
p. 221-228,
2019
Palavra-chave:
Serology;
gansos;
imunodiagnóstico
Áreas do conhecimento:
Ciências Biológicas; Medicina Veterinária
resumo ...
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ZAGO, SHARLINI LAÍS;
Marise Fonseca dos Santos;
KONRAD, DANIELA;
FIORINI, ADRIANA;
ROSADO, FÁBIO ROGÉRIO;
MISSIO, ROBSON FERNANDO;
Eliane Cristina Gruszka Vendruscolo
Palavra-chave:
Additives;
encapsulation;
survival and viability;
inoculants
Áreas do conhecimento:
Ciências Biológicas; Biotecnologia Industrial; Bioprocessos;
Ciências Biológicas; Microbiologia; Microbiologia Aplicada; Microbiologia Médica
resumo ...
(en)
Since abiotic and biotic factors can compromise the survival of bacteria and their viability, encapsulation of cells in biodegradable gel matrices, a biological macromolecule, is one alternative to have their shelf life extended. Here, it was developed a gel-based formulation of the bioinoculant Azospirillum brasilense strain AbV5 and determined the effect of trehalose and humic acid supplementation in viability and survival of bacteria. For each 2 ml of sodium alginate solution (3%), 1 ml of the inoculum was extruded in a solution containing sodium alginate complexed with calcium chloride, forming calcium alginate beads. Supplements were used in a ratio of 2:2:1. Treatments were peat; alginate; alginate + humic acid; alginate + trehalose 0.1 M; alginate + trehalose 1 M. Morphometric aspects, survival rate and viability were determined in 9 storage periods (3, 5, 7, 14, 21, 30, 45, 60, 90 days). As results, beads were able to sustain the growth of A. brasilense for 90 days. Shelf life quality decreased in all treatments and peat remained the best carrier. Encapsulation, despite promoting the greatest losses in the survival of bacteria in the first days, ensured better cell viability. Trehalose in low concentrations (0.1M) improved cell viability during storage, optimizing plant inoculation.
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Sharlini Lais Zago;
Marise Fonseca dos Santos;
Daniela Konrad;
Adriana Fiorini;
Fabio Rogério Rosado;
Robson Fernando Missio;
Eliane Cristina Gruszka Vendruscolo
Palavra-chave:
Additives;
encapsulation;
inoculants;
survival;
viability
Áreas do conhecimento:
CIENCIAS_AGRARIAS; Fitotecnia; Manejo e Tratos Culturais;
Ciências Biológicas; Biotecnologia; Biotecnologia Vegetal; Tecnologia de Processos e Produtos
resumo ...
(en)
Since abiotic and biotic factors can compromise the survival of bacteria and their viability, encapsulation of cells in biodegradable gel matrices, a biological macromolecule, is one alternative to have their shelf life extended. Here, it was developed a gel-based formulation of the bioinoculant Azospirillum brasilense strain AbV5 and determined the effect of trehalose and humic acid supplementation in viability and survival of bacteria. For each 2 ml of sodium alginate solution (3%), 1 ml of the inoculum was extruded in a solution containing sodium alginate complexed with calcium chloride, forming calcium alginate beads. Supplements were used in a ratio of 2:2:1. Treatments were peat; alginate; alginate + humic acid; alginate + trehalose 0.1 M; alginate + trehalose 1 M. Morphometric aspects, survival rate and viability were determined in 9 storage periods (3, 5, 7, 14, 21, 30, 45, 60, 90 days). As results, beads were able to sustain the growth of A. brasilense for 90 days. Shelf life quality decreased in all treatments and peat remained the best carrier. Encapsulation, despite promoting the greatest losses in the survival of bacteria in the first days, ensured better cell viability. Trehalose in low concentrations (0.1M) improved cell viability during storage, optimizing plant inoculation.
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Luiz Henrique Varzinczak;
MOURA, MAURICIO O.;
Fernando C. Passos
Palavra-chave:
Chiroptera;
climate;
Grinnellian niche;
leaf-nosed bats;
New World;
Phyllostomidae
Áreas do conhecimento:
Ciências Biológicas; Bioquímica dos Microorganismos; Enzimologia;
Ciências Biológicas; Zoologia; Taxonomia dos Grupos Recentes
resumo ...
Abstract. Climate underlies species distribution patterns, especially in species where climate limits distributions, such as the phyllostomid bats, which are mo
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Luiz H. Varzinczak;
Mauricio Osvaldo Moura;
Fernando Passos
Palavra-chave:
biologia comparada;
Macroecologia
resumo ...
Abstract. Climate underlies species distribution patterns, especially in species where climate limits distributions, such as the phyllostomid bats, which are mo
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GREGÓRIO, PAULO;
BARRETO, FELLYPE;
BIAGINI, GILSON;
MARTINS, ANA MARIA;
BOSQUETTI, BRUNA;
FLORES, ANDRESSA;
CUNHA, REGIANE;
ORTIZ, ALBERTO;
SÁNCHEZ-NIÑO, MARIA DOLORES;
Andréa Emília Marques Stinghen
NEPHROLOGY DIALYSIS TRANSPLANTATION (ONLINE),
v. 34,
n. Supplement_1,
p. i370-i370,
2019
DOI
Home page
Palavra-chave:
Fabry disease;
Endothelial dysfunction;
Syndecan-1
Áreas do conhecimento:
Ciências da Saúde; nephrology;
Ciências Biológicas; Fisiologia; Fisiologia de Órgãos e Sistemas; Fisiologia Endócrina
resumo ...
INTRODUCTION: Fabry disease is an X-linked lysosomal storage disorder caused by mutations in the GLA gene that lead to systemic involvement; being the brain, th
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Ademir Heldt;
Sabrina Suita;
Fabricio Martins Dutra;
Alexandre Leandro Pereira;
Eduardo Luis Cupertino Ballester
Palavra-chave:
nutrição;
isótopos estáveis;
Carcinicultura
Áreas do conhecimento:
CIENCIAS_AGRARIAS; Aqüicultura;
Ciências Biológicas; Biologia Geral; Aquacultura; Carcinicultura
resumo ...
(en)
Macrobrachium amazonicum is the native freshwater prawn species with the greatest potential for captive production in Brazil. The stable isotope carbon and nitrogen technique (δ 13 C and δ 15 N) is efficient to determine the contribution of different food sources to a given organism. We used this technique to estimate the contribution of the food sources in the biomass gain of M. amazonicum . Fish fillets were used to determine the isotopic fractionation between juveniles of M. amazonicum and a standard food source. Juvenile M. amazonicum were submitted to four treatments with different food availability to determine their contributions; T1: without soil substrate and with feed supply; T2: without soil substrate and feed supply; T3: with soil substrate, feed supply and addition of an aquatic macrophyte ( Elodea sp.); and, T4: with soil substrate, aquatic macrophytes and without feed supply. Periphyton, plankton and precipitated organic material were present in all treatments. The isotopic fractionation was 0.57 ± 0.07 (carbon) and 2.14 ± 0.18 (nitrogen). The prawn fed with ration presented growth 2.4 and 2.82 times higher in the treatments without substrate (T1) and with substrate and macrophytes (T3), respectively. The contribution of the food sources reinforces omnivore in prawn. The benthic organisms and feed supply were fundamental for the better growth performance of M. amazonicum . Estimating the effective contributions of food sources can help in developing diets more adequate for the species, increasing productivity, reducing costs and reducing the environmental impact of waste substances.
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